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Product Details
PA1-12719
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to the C-terminal of human Sphingosine Kinase 1.
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.08% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2195843
Product Specific Information
A suggested positive control for this product is MDBK cell lysate.
Target Information
SPHK1, along with SPHK2, catalyzes the phosphorylation of sphingosine producing the signaling molecule sphingosine-1-phosphate (S1P). S1P signals through G-protein coupled receptors and controls diverse cellular processes. Inhibitors of SPHKs are viewed as potential therapeutics for the treatment of cancer. SPHK1 catalyzes the phosphorylation of sphingosine to sphingosine 1 phosphate (S1P), an important signaling molecule with intra- and extracellular functions. Inside the cell S1P acts as a signaling molecule like other sphingolipid metabolites like ceramide and sphingosine. S1P has been implicated in regulating cell differentiation, calcium mobilization from intracellular stores, and apoptosis. The cell surface receptors for S1P are the EDG family of G protein-coupled receptors (S1P Receptors).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Acetyltransferase SPHK1; RP23-193A16.4; SK 1; SKase; Sphingosine kinase 1; SPK 1
Gene Aliases: 1110006G24Rik; SK1; SPHK; SPHK1; SPK; Spk1
UniProt ID: (Human) Q9NYA1, (Rat) Q91V26, (Mouse) Q8CI15
Entrez Gene ID: (Human) 8877, (Rat) 170897, (Mouse) 20698
magnesium ion binding
DNA binding
protein binding
calmodulin binding
ATP binding
sphinganine kinase activity
D-erythro-sphingosine kinase activity
sphingosine-1-phosphate receptor activity
protein phosphatase 2A binding
NAD+ kinase activity
diacylglycerol kinase activity
nucleotide binding
kinase activity
transferase activity
blood vessel development
positive regulation of protein phosphorylation
positive regulation of neurotransmitter secretion
sphingosine metabolic process
inflammatory response
protein kinase C-activating G-protein coupled receptor signaling pathway
brain development
female pregnancy
positive regulation of cell proliferation
cellular response to starvation
regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of neuron projection development
response to organic cyclic compound
response to amine
cyclooxygenase pathway
calcium-mediated signaling
positive regulation of cell growth
positive regulation of cell migration
positive regulation of protein ubiquitination
response to magnesium ion
response to progesterone
regulation of interleukin-1 beta production
response to ATP
positive regulation of NF-kappaB import into nucleus
negative regulation of apoptotic process
positive regulation of angiogenesis
positive regulation of mitotic cell cycle
positive regulation of smooth muscle contraction
lipid phosphorylation
positive regulation of fibroblast proliferation
positive regulation of NF-kappaB transcription factor activity
cellular response to hydrogen peroxide
response to interleukin-1
cellular response to growth factor stimulus
sphingosine-1-phosphate signaling pathway
positive regulation of peptidyl-threonine phosphorylation
phosphorylation
sphingosine biosynthetic process
protein folding
signal transduction
sphingolipid biosynthetic process
intracellular signal transduction
sphingoid catabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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