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Invitrogen
SPINK5 Recombinant Rabbit Monoclonal Antibody (9Z2V3)
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FIGURE: 1 / 1
SPINK5 Antibody (MA5-55561) in WB
Western Blot analysis of various lysates using SPINK5 Recombinant Monoclonal Antibody (Product # MA5-55561) at 1:1,000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) at 1:10,000 dilution. Lysates/proteins: 25 μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
MA5-55561
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
9Z2V3
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human SPINK5 LEKTI.
Conjugate
Form
Liquid
Concentration
2 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
RRID
AB_3667800
Product Specific Information
Immunogen Sequence: FKKGERDGDF ICPDYYEAVC GTDGKTYDNR CALCAENAKT GSQIGVKSEG ECKSSNPEQD VCSAFRPFVR DGRLGCTREN DPVLGPDGKT HGNKCAMCAE L
Target Information
Lympho-epithelial Kazal-type inhibitor (LEKTI) is a serine protease inhibitor which protects mucous epithelia against microbial attack and inflammation. LEKTI is a marker of epithelial differentiation and expresses strongly in the granular and uppermost spinous layers of the epidermis and differentiated layers of stratified epithelia. Defects in SPINK5, the gene encoding LEKTI, are the cause of Netherton syndrome, a severe autosomal recessive disorder characterized by atopic dermatitis, hayfever and other conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ISK5; LEKTI; Lympho-epithelial Kazal-type-related inhibitor; lymphoepithelial Kazal-type-related inhibitor; Netherton syndrome; serine peptidase inhibitor, Kazal type 5; Serine protease inhibitor Kazal-type 5; serine protease inhibitor, Kazal type 5
Gene Aliases: 2310065D10Rik; AV238912; LEKT1; LEKTI; LETK1; LETKI; NETS; NS; SPINK5; VAKT1; VAKTI
UniProt ID: (Human) Q9NQ38
Entrez Gene ID: (Human) 11005, (Rat) 361319, (Mouse) 72432
negative regulation of antibacterial peptide production
epidermal cell differentiation
negative regulation of angiogenesis
extracellular matrix organization
epithelial cell differentiation
hair cell differentiation
anagen
regulation of T cell differentiation
negative regulation of immune response
negative regulation of serine-type endopeptidase activity
biological_process
negative regulation of endopeptidase activity
regulation of cell adhesion
negative regulation of proteolysis
negative regulation of serine-type peptidase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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