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Invitrogen
SPPL2A Polyclonal Antibody
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Product Details
PA5-57509
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SPPL2A. Recombinant protein control fragment (Product #RP-95841).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2647884
Product Specific Information
Immunogen sequence: HASGNGTTKD YCMLYNPYWT ALPSTLENAT SISLMNLTST PLCNLSDIPP VGIKSKAVVV PWGSCHFLE
Highest antigen sequence identity to the following orthologs: Mouse - 72%, Rat - 75%.
Target Information
By searching sequence databases for homologs of Dictyostelium discoideum Impas, which shares homology with presenilin, followed by PCR of lymphocyte and hippocampus cDNA libraries, Grigorenko et al. (2002) cloned SPPL2a. This protein, which may act as an intramembrane protease, contains an N-terminal protease-associated (PA) domain, several transmembrane regions, a hydrophilic loop, conservative sequences around the first and second aspartate residues, and an invariant PAL motif near the C terminus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: IMP-3; intramembrane cleaving protease; Intramembrane protease 3; Presenilin-like protein 2; Signal peptide peptidase-like 2A; SPP-like 2A; SPPL2a protein
Gene Aliases: IMP3; PSEC0147; PSL2; SPPL2A
UniProt ID: (Human) Q8TCT8
Entrez Gene ID: (Human) 84888
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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