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Abnova
SPRY1 Polyclonal Antibody, MaxPab™
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FIGURE: 1 / 1
SPRY1 Antibody (H00010252-D01P) in WB
Western Blot analysis of SPRY1 expression in transfected 293T cell line (H00010252-T02) by SPRY1 MaxPab polyclonal antibody.
Lane 1: SPRY1 transfected lysate(35.10 KDa).
Lane 2: Non-transfected lysate.
Lane 1: SPRY1 transfected lysate(35.10 KDa).
Lane 2: Non-transfected lysate.
Product Details
H00010252-D01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SPRY1 (NP_005832.1, 1 a.a. approximately 319 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MDPQNQHGSG SSLVVIQQPS LDSRQRLDYE REIQPTAILS LDQIKAIRGS NEYTEGPSVV KRPAPRTAPR QEKHERTHEI IPINVNNNYE HRHTSHLGHA VLPSNARGPI LSRSTSTGSA ASSGSNSSAS SEQGLLGRSP PTRPVPGHRS ERAIRTQPKQ LIVDDLKGSL KEDLTQHKFI CEQCGKCKCG ECTAPRTLPS CLACNRQCLC SAESMVEYGT CMCLVKGIFY HCSNDDEGDS YSDNPCSCSQ SHCCSRYLCM GAMSLFLPCL LCYPPAKGCL KLCRRCYDWI HRPGCRCKNS NTVYCKLESC PSRGQGKPS
Target Information
Sprouty-1 and -2 are membrane-anchored phosphoprotein inhibitors of growth factor signaling in endothelial cells. Four mammalian Sprouty homologues (Sprouty-1-4) have been identified. One study showed that overexpressed Sprouty-1 and -2 inhibits fibroblast growth factor and vascular endothelial growth factor-induced proliferation and differentiation by repressing pathways leading to MAP kinase activation. Sprouty proteins are also endogenous inhibitors of the Ras/MAP kinase pathway that play an important role in the remodeling of branching tissues, such as in development of the lung, kidney tubules, vascular system, and breast ducts. A recent study shows that Sprouty-1 and -2 may have tumor suppressing activity in the breast, and found that both proteins are consistently down-regulated in breast carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Protein sprouty homolog 1; sprouty homolog 1, antagonist of FGF signaling; sprouty, Drosophila, homolog of, 1 (antagonist of FGF signaling); Spry-1
Gene Aliases: hSPRY1; SPRY1
UniProt ID: (Human) O43609
Entrez Gene ID: (Human) 10252
establishment of mitotic spindle orientation
metanephros development
ureteric bud development
organ induction
negative regulation of cell proliferation
negative regulation of GTPase activity
negative regulation of fibroblast growth factor receptor signaling pathway
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of MAP kinase activity
negative regulation of Ras protein signal transduction
negative regulation of neurotrophin TRK receptor signaling pathway
bud elongation involved in lung branching
negative regulation of ERK1 and ERK2 cascade
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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