Proteintech

SPRY4 Polyclonal Antibody

SPRY4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 6

SPRY4 Antibody (22765-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human cervical cancer tissue slide using 22765-1-AP ( SPRY4 Antibody) at dilution of 1:50 (under 40x lens).

Product Image Gallery

Product Details

22765-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SPRY4 Fusion Protein Ag18574 (1-165 aa encoded by BC125095)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.31 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MEPPIPQSA PLTPNSVMVQ PLLDSRMSHS RLQHPLTILP IDQVKTSHVE NDYIDNPSLA LTTGPKRTRG GAPELAPTPA RCDQDVTHHW ISFSGRPSSV SSSSSTSSDQ RLLDHMAPPP VADQASPRAV RIQPKVVHCQ PLDLKGPAVP PELDKHFLLC EACGKC (1-165 aa encoded by B C125095)

Target Information

SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. The protein is positioned upstream of RAS activation and impairs the formation of active GTP-RAS.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

SPRY4 promotes adipogenic differentiation of human mesenchymal stem cells through the MEK-ERK1/2 signaling pathway.

Adipocyte

Li N,Chen Y,Wang H,Li J,Zhao RC

Thu Dec 01 00:00:00 UTC 2022

Coupling HDAC4 with transcriptional factor MEF2D abrogates SPRY4-mediated suppression of ERK activation and elicits hepatocellular carcinoma drug resistance.

Cancer letters

Ma Q,Xu Q,Zhao J,Zhang W,Wang Q,Fang J,Lu Z,Liu J,Ma L

Mon Nov 01 00:00:00 UTC 2021

Targeting enhancer reprogramming to mitigate MEK inhibitor resistance in preclinical models of advanced ovarian cancer.

The Journal of clinical investigation

Liu S,Zou Q,Chen JP,Yao X,Guan P,Liang W,Deng P,Lai X,Yin J,Chen J,Chen R,Yu Z,Xiao R,Sun Y,Hong JH,Liu H,Lu H,Chen J,Bei JX,Koh J,Chan JY,Wang B,Kang T,Yu Q,Teh BT,Liu J,Xiong Y,Tan J

Fri Oct 15 00:00:00 UTC 2021

SPRY4 regulates trophoblast proliferation and apoptosis via regulating IFN-γ-induced STAT1 expression and activation in recurrent miscarriage.

American journal of reproductive immunology (New York, N.Y. : 1989)

Qin S,Zhang Y,Zhang J,Tian F,Sun L,He X,Ma X,Zhang J,Liu XR,Zeng W,Lin Y

Mon Jun 01 00:00:00 UTC 2020

SPRY4 regulates trophoblast proliferation and apoptosis via regulating IFN-γ-induced STAT1 expression and activation in recurrent miscarriage.

American journal of reproductive immunology (New York, N.Y. : 1989)

Qin S,Zhang Y,Zhang J,Tian F,Sun L,He X,Ma X,Zhang J,Liu XR,Zeng W,Lin Y

Mon Jun 01 00:00:00 UTC 2020

SPRY4 regulates trophoblast proliferation and apoptosis via regulating IFN-γ-induced STAT1 expression and activation in recurrent miscarriage.

American journal of reproductive immunology (New York, N.Y. : 1989)

Qin S,Zhang Y,Zhang J,Tian F,Sun L,He X,Ma X,Zhang J,Liu XR,Zeng W,Lin Y

Mon Jun 01 00:00:00 UTC 2020

AXL confers intrinsic resistance to osimertinib and advances the emergence of tolerant cells.

Nature communications

Taniguchi H,Yamada T,Wang R,Tanimura K,Adachi Y,Nishiyama A,Tanimoto A,Takeuchi S,Araujo LH,Boroni M,Yoshimura A,Shiotsu S,Matsumoto I,Watanabe S,Kikuchi T,Miura S,Tanaka H,Kitazaki T,Yamaguchi H,Mukae H,Uchino J,Uehara H,Takayama K,Yano S

Wed Jan 16 00:00:00 UTC 2019

SPRY4 is responsible for pathogenesis of adolescent idiopathic scoliosis by contributing to osteogenic differentiation and melatonin response of bone marrow-derived mesenchymal stem cells.

Cell death & disease

Li J,Li N,Chen Y,Hui S,Fan J,Ye B,Fan Z,Zhang J,Zhao RC,Zhuang Q

Wed Oct 23 00:00:00 UTC 2019

SPRY4 is responsible for pathogenesis of adolescent idiopathic scoliosis by contributing to osteogenic differentiation and melatonin response of bone marrow-derived mesenchymal stem cells.

Cell death & disease

Li J,Li N,Chen Y,Hui S,Fan J,Ye B,Fan Z,Zhang J,Zhao RC,Zhuang Q

Wed Oct 23 00:00:00 UTC 2019

Bioinformatics

Protein Aliases: Protein sprouty homolog 4; Sprouty 4; sprouty homolog 4; Spry-4

View more View less

Gene Aliases: HH17; SPRY4

View more View less

UniProt ID: (Human) Q9C004

View more View less

Entrez Gene ID: (Human) 81848

View more View less

Function(s)

protein binding

Process(es)

multicellular organism development negative regulation of ERK1 and ERK2 cascade

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

SPRY4 Polyclonal Antibody

SPRY4 Antibody (22765-1-AP) in IHC (P)

Product Details

22765-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!