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Invitrogen
SPRYD2 Polyclonal Antibody
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Product Details
PA5-21170
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
An 18 amino acid peptide near the carboxy terminus of human SPRYD2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11153374
Product Specific Information
A suggested positive control is mouse heart tissue lysate.
PA5-21170 can be used with blocking peptide PEP-1284.
Target Information
SPRYD2, also known as Myospryn, was originally identified as the muscle-specific partner of dysbindin and as a Mef-2 target gene. It is a large scaffolding protein localized to the Z-disc/costamere region of striated muscle. SPRYD2 includes a noncanonical tripartite motif (TRIM-like) that lacks the RING domain but consists of a B-box coiled coil (BBC), fibronectin 3 (FN3) repeats, and SPRY domains. SPRYD2 interacts with desmin and calcineurin, and it has been suggested to play a role in the biogenesis of lysosome and negatively regulates slow-fiber-type transformation and skeletal muscle regeneration. SPRYD2 is dysregulated in Duchenne muscular dystrophy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2310076E16Rik; cardiomyopathy associated 5; Cardiomyopathy-associated protein 5; Dystrobrevin-binding protein 2; Genethonin-3; heart and skeletal muscle-specific and sprouty domain-containing; Myospryn; SPRY domain-containing protein 2; stretch response protein 553; stretch-response protein 553; stretch-responsive fibronectin protein type 3; TRIM-like protein; tripartite motif-containing 76; Tripartite motif-containing protein 76
Gene Aliases: 2310076E16Rik; 2310076E21Rik; AA420382; AI504003; C5orf10; CMYA5; DTNBP2; SPRYD2; sr553; Srfsd; Tims; TRIM76
UniProt ID: (Human) Q8N3K9
Entrez Gene ID: (Human) 202333, (Rat) 688915, (Mouse) 76469
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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