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Product Details
IHC-00157
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residues 2150 and 2200 of Human Spectrin Non-Erythroid Beta 1.
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Wet ice
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Spectrin (Sp), the most abundant of the erythrocyte membrane skeleton proteins, helps these cells maintain their characteristic biconcave shape while remaining flexible and elastic. Erythrocyte Sp is a heterodimer composed of a 280 kDa alpha subunit and a 246 kDa beta subunit which associate in a side-to-side, antiparallel configuration to form a 100 nm rod-like structure. Sp in other tissues may be composed of distinct but homologous alpha and beta subunits, sometimes referred to as fodrin. A newly introduced nomenclature designates the Sp subunits of the erythrocyte as alpha-1 and beta-1, and the fodrin subunits as alpha-2 and beta-2. Alternatively spliced forms of each are designated as epsilon-1, epsilon-2, etc. (e. g. beta-1 epsilon-1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: beta-fodrin; beta-G spectrin; Beta-II spectrin; beta-spectrin 2; beta-spectrin II; beta-spectrin non-erythrocytic 1; embryonic liver beta-fodrin; embryonic liver fodrin beta chain; epididymis luminal protein 102; Fodrin beta chain; spectrin beta chain, brain 1; Spectrin beta chain, non-erythrocytic 1; spectrin, beta, non-erythrocytic 1; Spectrin, non-erythroid beta chain 1
Gene Aliases: betaSpII; ELF; HEL102; SPTB2; SPTBN1
UniProt ID: (Human) Q01082
Entrez Gene ID: (Human) 6711
MAPK cascade
mitotic cytokinesis
ER to Golgi vesicle-mediated transport
plasma membrane organization
cytoskeleton organization
common-partner SMAD protein phosphorylation
SMAD protein import into nucleus
axon guidance
Golgi to plasma membrane protein transport
positive regulation of GTPase activity
actin filament capping
membrane assembly
protein targeting to plasma membrane
cell-cell adhesion
positive regulation of interleukin-2 secretion
regulation of protein localization to plasma membrane
positive regulation of protein localization to plasma membrane
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