Proteintech

SPTLC1 Polyclonal Antibody

SPTLC1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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SPTLC1 Antibody (15376-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human colon cancer using 15376-1-AP (SPTLC1 antibody) at dilution of 1:100 (under 40x lens).

SPTLC1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

15376-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 10 publications 10 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunoprecipitation (IP)

0.5-4.0 µg

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SPTLC1 Fusion Protein Ag1162 (1-143 aa encoded by BC007085)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MATATEQWV LVEMVQALYE APAYHLILEG ILILWIIRLL FSKTYKLQER SDLTVKEKEE LIEEWQPEPL VPPVPKDHPA LNYNIVSGPP SHKTVVNGKE CINFASFNFL GLLDNPRVKA AALASLKKYG VGTCGPRGFY GTFE (1-143 aa encoded by BC007085)

Target Information

Serine palmitoyltransferase (SPT) is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Inhibiting de novo ceramide synthesis restores mitochondrial and protein homeostasis in muscle aging.

Science translational medicine

Lima TI,Laurila PP,Wohlwend M,Morel JD,Goeminne LJE,Li H,Romani M,Li X,Oh CM,Park D,Rodríguez-López S,Ivanisevic J,Gallart-Ayala H,Crisol B,Delort F,Batonnet-Pichon S,Silveira LR,Sankabattula Pavani Veera Venkata L,Padala AK,Jain S,Auwerx J

Wed May 17 00:00:00 UTC 2023

Stearate-derived very long-chain fatty acids are indispensable to tumor growth.

The EMBO journal

Chu Q,Liu P,Song Y,Yang R,An J,Zhai X,Niu J,Yang C,Li B

Mon Jan 16 00:00:00 UTC 2023

Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy.

Science advances

Laurila PP,Luan P,Wohlwend M,Zanou N,Crisol B,Imamura de Lima T,Goeminne LJE,Gallart-Ayala H,Shong M,Ivanisevic J,Place N,Auwerx J

Fri Jan 28 00:00:00 UTC 2022

Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia.

Nature aging

Laurila PP,Wohlwend M,Imamura de Lima T,Luan P,Herzig S,Zanou N,Crisol B,Bou-Sleiman M,Porcu E,Gallart-Ayala H,Handzlik MK,Wang Q,Jain S,D'Amico D,Salonen M,Metallo CM,Kutalik Z,Eichmann TO,Place N,Ivanisevic J,Lahti J,Eriksson JG,Auwerx J

Thu Dec 01 00:00:00 UTC 2022

Exercise training enhances muscle mitochondrial metabolism in diet-resistant obesity.

EBioMedicine

Pileggi CA,Blondin DP,Hooks BG,Parmar G,Alecu I,Patten DA,Cuillerier A,O'Dwyer C,Thrush AB,Fullerton MD,Bennett SA,Doucet É,Haman F,Cuperlovic-Culf M,McPherson R,Dent RRM,Harper ME

Thu Sep 01 00:00:00 UTC 2022

1-Deoxysphingolipid synthesis compromises anchorage-independent growth and plasma membrane endocytosis in cancer cells.

Journal of lipid research

Cordes T,Kuna RS,McGregor GH,Khare SV,Gengatharan J,Muthusamy T,Metallo CM

Sat Oct 01 00:00:00 UTC 2022

Central Ceramide Signaling Mediates Obesity-Induced Precocious Puberty.

Cell metabolism

Heras V,Castellano JM,Fernandois D,Velasco I,Rodríguez-Vazquez E,Roa J,Vazquez MJ,Ruiz-Pino F,Rubio M,Pineda R,Torres E,Avendaño MS,Paredes A,Pinilla L,Belsham D,Diéguez C,Gaytán F,Casals N,López M,Tena-Sempere M

Tue Dec 01 00:00:00 UTC 2020

Knockout of neutrophil elastase protects against western diet induced nonalcoholic steatohepatitis in mice by regulating hepatic ceramides metabolism.

Biochemical and biophysical research communications

Chen J,Liang B,Bian D,Luo Y,Yang J,Li Z,Zhuang Z,Zang S,Shi J

Tue Oct 22 00:00:00 UTC 2019

Activation of Mitochondrial Unfolded Protein Response in SHSY5Y Expressing APP Cells and APP/PS1 Mice.

Frontiers in cellular neuroscience

Shen Y,Ding M,Xie Z,Liu X,Yang H,Jin S,Xu S,Zhu Z,Wang Y,Wang D,Xu L,Zhou X,Wang P,Bi J

Wed Sep 30 00:00:00 UTC 2020

Neutrophil elastase increases airway ceramide levels via upregulation of serine palmitoyltransferase.

American journal of physiology. Lung cellular and molecular physiology

Karandashova S,Kummarapurugu AB,Zheng S,Chalfant CE,Voynow JA

Mon Jan 01 00:00:00 UTC 2018

Inhibition of serine palmitoyltransferase reduces Aβ and tau hyperphosphorylation in a murine model: a safe therapeutic strategy for Alzheimer's disease.

Neurobiology of aging

Geekiyanage H,Upadhye A,Chan C

Thu Aug 01 00:00:00 UTC 2013

Inhibition of serine palmitoyltransferase reduces Aβ and tau hyperphosphorylation in a murine model: a safe therapeutic strategy for Alzheimer's disease.

Neurobiology of aging

Geekiyanage H,Upadhye A,Chan C

Thu Aug 01 00:00:00 UTC 2013

Inhibition of serine palmitoyltransferase reduces Aβ and tau hyperphosphorylation in a murine model: a safe therapeutic strategy for Alzheimer's disease.

Neurobiology of aging

Geekiyanage H,Upadhye A,Chan C

Thu Aug 01 00:00:00 UTC 2013

Inhibition of serine palmitoyltransferase reduces Aβ and tau hyperphosphorylation in a murine model: a safe therapeutic strategy for Alzheimer's disease.

Neurobiology of aging

Geekiyanage H,Upadhye A,Chan C

Thu Aug 01 00:00:00 UTC 2013

MicroRNA-137/181c regulates serine palmitoyltransferase and in turn amyloid β, novel targets in sporadic Alzheimer's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Geekiyanage H,Chan C

Wed Oct 12 00:00:00 UTC 2011

MicroRNA-137/181c regulates serine palmitoyltransferase and in turn amyloid β, novel targets in sporadic Alzheimer's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Geekiyanage H,Chan C

Wed Oct 12 00:00:00 UTC 2011

Bioinformatics

Protein Aliases: hLCB1; HSAN; LCB 1; Long chain base biosynthesis protein 1; MGC14645; RP11-118F2.1; serine C-palmitoyltransferase; Serine palmitoyltransferase 1; serine palmitoyltransferase subunit 1; serine palmitoyltransferase, long chain base subunit 1; Serine-palmitoyl-CoA transferase 1; SPT 1; SPT1

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Gene Aliases: AW552086; C77762; E030036H05; HSAN1; HSN1; LBC1; LCB1; rCG_44191; RGD1306617; SPT1; SPTI; SPTLC1

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UniProt ID: (Human) O15269, (Mouse) O35704, (Rat) D4A2H2

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Entrez Gene ID: (Human) 10558, (Mouse) 268656, (Rat) 361213

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Function(s)

serine C-palmitoyltransferase activity protein binding pyridoxal phosphate binding catalytic activity transferase activity transferase activity, transferring acyl groups

Process(es)

lipid metabolic process sphingolipid metabolic process sphingomyelin biosynthetic process biosynthetic process sphinganine biosynthetic process sphingosine biosynthetic process ceramide biosynthetic process sphingolipid biosynthetic process positive regulation of lipophagy

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SPTLC1 Polyclonal Antibody

SPTLC1 Antibody (15376-1-AP) in IHC (P)

Product Details

15376-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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