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Product Details
MA5-33380
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3D12
Conjugate
Form
Liquid
Concentration
100 µg/mL
Purification
Protein G
Storage buffer
PBS with 0.1% BSA
Contains
no preservative
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2815518
Product Specific Information
Product is supplied at 1 mL (100 µL/mL).
Application Notes: Functional Assay- This antibody is useful for neutralization of the biological activity of SR-BI. For neutralization of biological activity dilutions have to be made according to the amounts SR-BI to be inactivated.
Target Information
High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. The SR-BI binds HDLs and mediates selective uptake of HDL cholesteryl ester. SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidgenic tissues, and mediates selective cholesterol uptake by a distinct mechanism. In mice, it seems that SR-BI plays a key role in determining the levels of plasma lipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD36 antigen (collagen type I receptor thrombospondin receptor)-like 1 (scavanger receptor class B type 1); CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; scavanger receptor class B type 1; scavenger receptor b1; Scavenger receptor class B member 1; SR-BI; SRB1
Gene Aliases: Cd36l1; Scarb1; SR-B1; Srb1
UniProt ID: (Rat) P97943
Entrez Gene ID: (Rat) 25073
lipopolysaccharide binding
phosphatidylserine binding
lipopolysaccharide receptor activity
lipid transporter activity
high-density lipoprotein particle binding
low-density lipoprotein particle binding
apolipoprotein binding
apolipoprotein A-I binding
protein homodimerization activity
high-density lipoprotein particle receptor activity
endothelial cell proliferation
steroid biosynthetic process
androgen biosynthetic process
cholesterol catabolic process
lipid transport
receptor-mediated endocytosis
phagocytosis, recognition
cell adhesion
positive regulation of triglyceride biosynthetic process
positive regulation of cholesterol storage
regulation of phosphatidylcholine catabolic process
phospholipid transport
lipopolysaccharide transport
cholesterol transport
lipopolysaccharide-mediated signaling pathway
detection of lipopolysaccharide
cholesterol efflux
high-density lipoprotein particle remodeling
low-density lipoprotein particle clearance
high-density lipoprotein particle clearance
vitamin transmembrane transport
cholesterol homeostasis
blood vessel endothelial cell migration
recognition of apoptotic cell
reverse cholesterol transport
adhesion of symbiont to host
regulation of phagocytosis
positive regulation of nitric-oxide synthase activity
triglyceride homeostasis
cholesterol import
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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