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Invitrogen
SR-BI Recombinant Rabbit Monoclonal Antibody (SR37-06)
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Product Details
MA5-32001
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
SR37-06
Immunogen
Synthetic peptide within Human SRB1 aa 81-130
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2809295
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. The SR-BI binds HDLs and mediates selective uptake of HDL cholesteryl ester. SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidgenic tissues, and mediates selective cholesterol uptake by a distinct mechanism. In mice, it seems that SR-BI plays a key role in determining the levels of plasma lipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD36; CD36 and LIMPII analogous 1; CD36 antigen (collagen type I receptor thrombospondin receptor)-like 1 (scavanger receptor class B type 1); CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; CD36 antigen-like 1; CLA-1; Collagen type I receptor, thrombospondin receptor-like 1; HDL QTL 1; scavanger receptor class B type 1; scavenger receptor b1; Scavenger receptor class B member 1; scavenger receptor class B type I; scavenger receptor class B type III; scavenger receptor class B, member 1; scavenger receptor class B1; SR-BI; SRB1
Gene Aliases: AI120173; CD36; CD36L1; CLA-1; CLA1; D5Ertd460e; Hdlq1; HDLQTL6; Hlb398; mSR-BI; SCARB1; SR-B1; SR-BI; SRB1; SRBI
UniProt ID: (Human) Q8WTV0, (Rat) P97943, (Mouse) Q61009
Entrez Gene ID: (Human) 949, (Rat) 25073, (Mouse) 20778
lipopolysaccharide binding
virus receptor activity
phosphatidylserine binding
lipopolysaccharide receptor activity
transporter activity
protein binding
1-phosphatidylinositol binding
high-density lipoprotein particle binding
low-density lipoprotein particle binding
apolipoprotein binding
apolipoprotein A-I binding
protein homodimerization activity
high-density lipoprotein particle receptor activity
lipid transporter activity
endothelial cell proliferation
steroid biosynthetic process
androgen biosynthetic process
cholesterol catabolic process
lipid transport
receptor-mediated endocytosis
phagocytosis, recognition
cell adhesion
positive regulation of triglyceride biosynthetic process
positive regulation of cholesterol storage
regulation of phosphatidylcholine catabolic process
phospholipid transport
lipopolysaccharide transport
cholesterol transport
lipopolysaccharide-mediated signaling pathway
detection of lipopolysaccharide
cholesterol efflux
high-density lipoprotein particle remodeling
low-density lipoprotein particle clearance
high-density lipoprotein particle clearance
vitamin transmembrane transport
cholesterol homeostasis
blood vessel endothelial cell migration
recognition of apoptotic cell
reverse cholesterol transport
adhesion of symbiont to host
regulation of phagocytosis
positive regulation of nitric-oxide synthase activity
triglyceride homeostasis
cholesterol import
pattern recognition receptor signaling pathway
positive regulation of endothelial cell migration
wound healing
lipoprotein metabolic process
viral entry into host cell
intestinal absorption
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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