Invitrogen

SRC1 Recombinant Rabbit Monoclonal Antibody (3S4C6)

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

MA5-42905

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1 µg/mL
-

Immunoprecipitation (IP)

0.5 µg-4 µg antibody for 200 µg-400 µg extracts of
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Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

3S4C6

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 400-750 of human KAT13A / SRC1 (Q15788).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.55 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2912046

Product Specific Information

Positive test controls include: HeLa, 293T, SGC-7901.

Immunogen sequence: VARSSTLPPS NSNMVSTRIN RQQSSDLHSS SHSNSSNSQG SFGCSPGSQI VANVALNQGQ ASSQSSNPSL NLNNSPMEGT GISLAQFMSP RRQVTSGLAT RPRMPNNSFP PNISTLSSPV GMTSSACNNN NRSYSNIPVT SLQGMNEGPN NSVGFSASSP VLRQMSSQNS PSRLNIQPAK AESKDNKEIA SILNEMIQSD NSSSDGKPLD SGLLHNNDRL SDGDSKYSQT SHKLVQLLTT TAEQQLRHAD IDTSCKDVLS CTGTSNSASA NSSGGSCPSS HSSLTERHKI LHRLLQEGSP SDITTLSVEP DKKDSASTSV SVTGQVQGNS SIKLELDASK KKESKDHQLL R

Target Information

Clone 1135 recognizes SRC-1, steroid-receptor coactivator-1. SRC-1 is a member of a gene family that functions in the full transcriptional activation of the steroid hormone receptor superfamily and contains intrinsic histone acetyltransferase activity. SRC-1 has a molecular weight of 160 kDa and has a basic helix-loop-helix (bHLH)-PAS domain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ASV; bHLHe74; c-SRC; Class E basic helix-loop-helix protein 74; Hin-2 protein; NCoA-1; Nuclear receptor coactivator 1; p60-Src; PAX3/NCOA1 fusion protein; Protein Hin-2; Renal carcinoma antigen NY-REN-52; RIP160; SRC-1; SRC-1 (-Q); Steroid receptor coactivator 1; steroid receptor coactivator-1

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Gene Aliases: bHLHe42; BHLHE74; F-SRC-1; KAT13A; NCOA1; RIP160; SRC1

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UniProt ID: (Human) Q15788

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Entrez Gene ID: (Human) 8648

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Function(s)
RNA polymerase II regulatory region DNA binding RNA polymerase II transcription coactivator activity chromatin binding transcription coactivator activity histone acetyltransferase activity protein binding ligand-dependent nuclear receptor binding enzyme binding estrogen receptor binding ligand-dependent nuclear receptor transcription coactivator activity protein complex binding progesterone receptor binding nuclear hormone receptor binding retinoid X receptor binding protein dimerization activity protein N-terminus binding androgen receptor binding
Process(es)
positive regulation of transcription from RNA polymerase II promoter by galactose regulation of thyroid hormone mediated signaling pathway transcription, DNA-templated lactation male gonad development bile acid and bile salt transport cerebellum development hippocampus development hypothalamus development cerebral cortex development androgen receptor signaling pathway intracellular receptor signaling pathway response to estradiol response to retinoic acid response to progesterone cellular response to hormone stimulus positive regulation of apoptotic process histone H4 acetylation cellular lipid metabolic process estrous cycle positive regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of female receptivity positive regulation of transcription from RNA polymerase II promoter male mating behavior labyrinthine layer morphogenesis cellular response to Thyroglobulin triiodothyronine regulation of cellular response to drug
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