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OriGene
SREBF2 Monoclonal Antibody (OTI4G1), TrueMAB™
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FIGURE: 1 / 1
SREBF2 Antibody (CF806342) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SREBF2 (RC208942, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-SREBF. Positive lysates LY417881 (100 µg) and LC417881 (20 µg) can be purchased separately from OriGene.
Product Details
CF806342
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI4G1
Immunogen
Human recombinant protein fragment corresponding to amino acids 117-380 of human SREBF2 produced in E.coli.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bHLHd2; Class D basic helix-loop-helix protein 2; SREBP-2; Sterol regulatory element-binding protein 2; Sterol regulatory element-binding transcription factor 2
Gene Aliases: BHLHD2; SREBF2; SREBP-2; SREBP2
UniProt ID: (Human) Q12772
Entrez Gene ID: (Human) 6721
C-8 sterol isomerase activity
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
protein binding
protein C-terminus binding
protein dimerization activity
E-box binding
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
lipid metabolic process
cholesterol metabolic process
cellular response to starvation
positive regulation of cholesterol storage
positive regulation of transcription from RNA polymerase II promoter
response to low-density lipoprotein particle
cellular response to laminar fluid shear stress
regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
negative regulation of cholesterol efflux
regulation of mitophagy
positive regulation of protein targeting to mitochondrion
regulation of cholesterol homeostasis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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