Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Proteintech
SRGAP2 Polyclonal Antibody
Promotion
View available promotion(s)
Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
22519-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SRGAP2 Fusion Protein Ag18278 (784-944 aa encoded by BC132874)
Conjugate
Form
Liquid
Concentration
0.38 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: VQDTEDGVV ERSSPKSEIE VISEPPEEKV TARAGASCPS GGHVADIYLA NINKQRKRPE SGSIRKTFRS DSHGLSSSLT DSSSPGVGAS CRPSSQPIMS QSLPKEGPDK CSISGHGSLN SISRHSSLKN RLDSPQIRKT ATAGRSKSFN NHRPMDPEVI AQ (784-944 aa encoded by BC132874)
Target Information
This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FBP-27; formin binding protein 2; Formin-binding protein 2; Formin-binding protein 27; Rho GTPase-activating protein 34; SLIT-ROBO GAP2; SLIT-ROBO Rho GTPase-activating protein 2; srGAP2
Gene Aliases: 9930124L22Rik; AI448945; ARHGAP34; FBP2; Fbp27; FNBP2; KIAA0456; SRGAP2; SRGAP2A; SRGAP3
UniProt ID: (Human) O75044, (Mouse) Q91Z67
Entrez Gene ID: (Human) 23380, (Mouse) 14270
lamellipodium assembly involved in ameboidal cell migration
signal transduction
nervous system development
extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration
negative regulation of cell migration
substrate adhesion-dependent cell spreading
positive regulation of GTPase activity
filopodium assembly
neuron projection morphogenesis
actin filament severing
dendritic spine development
negative regulation of neuron migration
cell proliferation
regulation of small GTPase mediated signal transduction
negative regulation of cell death
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support