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Invitrogen
SRGAP2 Polyclonal Antibody
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Product Details
PA5-70681
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide directed towards the N terminal region of human SRGAP2
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2690606
Product Specific Information
This target displays homology in the following species: Cow: 87%; Dog: 100%; Guinea Pig: 87%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 87%
Target Information
This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Formin-binding protein 2; Rho GTPase-activating protein 34; SLIT-ROBO GAP2; SLIT-ROBO Rho GTPase-activating protein 2; srGAP2
Gene Aliases: ARHGAP34; FNBP2; KIAA0456; SRGAP2; SRGAP2A; SRGAP3
UniProt ID: (Human) O75044
Entrez Gene ID: (Human) 23380
lamellipodium assembly involved in ameboidal cell migration
signal transduction
cell proliferation
extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration
substrate adhesion-dependent cell spreading
positive regulation of GTPase activity
filopodium assembly
neuron projection morphogenesis
actin filament severing
regulation of small GTPase mediated signal transduction
negative regulation of cell death
dendritic spine development
negative regulation of neuron migration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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