Proteintech

SRI Polyclonal Antibody

SRI Antibody in Immunocytochemistry (ICC/IF)

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SRI Antibody (16471-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells using 16471-1-AP (SRI antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

SRI Antibody in Immunohistochemistry (Paraffin) (IHC (P))

SRI Antibody in Immunoprecipitation (IP)

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Product Details

16471-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:250-1:1,000

Immunocytochemistry (ICC/IF)

1:20-1:200

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SRI Fusion Protein Ag9553 (1-198 aa encoded by BC011025)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAYPGHPGA GGGYYPGGYG GAPGGPAFPG QTQDPLYGYF AAVAGQDGQI DADELQRCLT QSGIAGGYKP FNLETCRLMV SMLDRDMSGT MGFNEFKELW AVLNGWRQHF ISFDTDRSGT VDPQELQKAL TTMGFRLSPQ AVNSIAKRYS TNGKITFDDY IACCVKLRAL TDSFRRRDTA QQGVVNFPYD DFIQCVMSV (1-198 aa encoded by BC011025 )

Target Information

Sorcin is a 198 amino acid, soluble, resistance-related, calcium-binding cytosolic protein belonging to the penta-EF hand (PEF) family of calcium binding proteins and contains 4 EF-hand calcium-binding motifs. Human Sorcin is known to share 95% sequence identity with hamster Sorcin. It is known to associate with the sarcolemmal proteins Annexin VII, cardiac ryanodine receptors and L-type Ca2+ channels and thus influence the intracellular Ca (2+)-homeostasis. It is also important in the regulation of intracellular Ca2+ cycling and Ca2+ influx pathways in the heart and skeletal muscle during excitation-contraction. It is overproduced in many multi-drug resistance (MDR) cells and regulates cell apoptosis pathways, thus acting as a new MDR marker for prognosis of acute myeloid leukemia (AML) and a good target for anti-MDR drug development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

AnnexinA7 promotes epithelial-mesenchymal transition by interacting with Sorcin and contributes to aggressiveness in hepatocellular carcinoma.

Cell death & disease

Ling F,Zhang H,Sun Y,Meng J,Sanches JGP,Huang H,Zhang Q,Yu X,Wang B,Hou L,Zhang J

Fri Oct 29 00:00:00 UTC 2021

AnnexinA7 promotes epithelial-mesenchymal transition by interacting with Sorcin and contributes to aggressiveness in hepatocellular carcinoma.

Cell death & disease

Ling F,Zhang H,Sun Y,Meng J,Sanches JGP,Huang H,Zhang Q,Yu X,Wang B,Hou L,Zhang J

Fri Oct 29 00:00:00 UTC 2021

AnnexinA7 promotes epithelial-mesenchymal transition by interacting with Sorcin and contributes to aggressiveness in hepatocellular carcinoma.

Cell death & disease

Ling F,Zhang H,Sun Y,Meng J,Sanches JGP,Huang H,Zhang Q,Yu X,Wang B,Hou L,Zhang J

Fri Oct 29 00:00:00 UTC 2021

AnnexinA7 promotes epithelial-mesenchymal transition by interacting with Sorcin and contributes to aggressiveness in hepatocellular carcinoma.

Cell death & disease

Ling F,Zhang H,Sun Y,Meng J,Sanches JGP,Huang H,Zhang Q,Yu X,Wang B,Hou L,Zhang J

Fri Oct 29 00:00:00 UTC 2021

Knockdown of sorcin increases HEI-OC1 cell damage induced by cisplatin in vitro.

Archives of biochemistry and biophysics

Wang D,Shi S,Hsieh YL,Wang J,Wang H,Wang W

Thu Apr 15 00:00:00 UTC 2021

Knockdown of sorcin increases HEI-OC1 cell damage induced by cisplatin in vitro.

Archives of biochemistry and biophysics

Wang D,Shi S,Hsieh YL,Wang J,Wang H,Wang W

Thu Apr 15 00:00:00 UTC 2021

Combination of dihydromyricetin and ondansetron strengthens antiproliferative efficiency of adriamycin in K562/ADR through downregulation of SORCIN: A new strategy of inhibiting P-glycoprotein.

Journal of cellular physiology

Sun Y,Liu W,Wang C,Meng Q,Liu Z,Huo X,Yang X,Sun P,Sun H,Ma X,Peng J,Liu K

Mon Apr 01 00:00:00 UTC 2019

Combination of dihydromyricetin and ondansetron strengthens antiproliferative efficiency of adriamycin in K562/ADR through downregulation of SORCIN: A new strategy of inhibiting P-glycoprotein.

Journal of cellular physiology

Sun Y,Liu W,Wang C,Meng Q,Liu Z,Huo X,Yang X,Sun P,Sun H,Ma X,Peng J,Liu K

Mon Apr 01 00:00:00 UTC 2019

Targeting P-glycoprotein and SORCIN: Dihydromyricetin strengthens anti-proliferative efficiency of adriamycin via MAPK/ERK and Ca²⁺ -mediated apoptosis pathways in MCF-7/ADR and K562/ADR.

Journal of cellular physiology

Sun Y,Wang C,Meng Q,Liu Z,Huo X,Sun P,Sun H,Ma X,Peng J,Liu K

Sun Apr 01 00:00:00 UTC 2018

Targeting P-glycoprotein and SORCIN: Dihydromyricetin strengthens anti-proliferative efficiency of adriamycin via MAPK/ERK and Ca²⁺ -mediated apoptosis pathways in MCF-7/ADR and K562/ADR.

Journal of cellular physiology

Sun Y,Wang C,Meng Q,Liu Z,Huo X,Sun P,Sun H,Ma X,Peng J,Liu K

Sun Apr 01 00:00:00 UTC 2018

Bioinformatics

Protein Aliases: 22 kDa protein; calcium binding protein amplified in mutlidrug-resistant cells; CP-22; CP22; H_RG167B05.1; Sorcin; V19

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Gene Aliases: 2210417O06Rik; 2900070H08Rik; CP-22; CP22; SCN; Sor; SRI; V19

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UniProt ID: (Human) P30626, (Mouse) Q6P069

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Entrez Gene ID: (Human) 6717, (Mouse) 109552, (Rat) 683667

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Function(s)

protease binding calcium-dependent cysteine-type endopeptidase activity receptor binding calcium channel regulator activity calcium ion binding protein binding ion channel binding protein heterodimerization activity repressing transcription factor binding metal ion binding

Process(es)

action potential proteolysis transport calcium ion transport intracellular sequestering of iron ion regulation of striated muscle contraction signal transduction heart development muscle organ development regulation of heart contraction negative regulation of heart rate regulation of cell communication by electrical coupling regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum positive regulation of insulin secretion involved in cellular response to glucose stimulus cytoplasmic sequestering of transcription factor positive regulation of release of sequestered calcium ion into cytosol regulation of calcium ion transport negative regulation of ryanodine-sensitive calcium-release channel activity regulation of cardiac muscle cell contraction regulation of relaxation of muscle regulation of high voltage-gated calcium channel activity regulation of cell communication by electrical coupling involved in cardiac conduction negative regulation of transcription regulatory region DNA binding

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SRI Polyclonal Antibody

SRI Antibody (16471-1-AP) in ICC/IF

Product Details

16471-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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