Proteintech

SRP68 Polyclonal Antibody

SRP68 Antibody in Immunocytochemistry (ICC/IF)

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SRP68 Antibody (11585-1-AP) in ICC/IF

Immunofluorescent analysis of ( 4% PFA) fixed HepG2 cells using 11585-1-AP (SRP68 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

SRP68 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

SRP68 Antibody in Immunoprecipitation (IP)

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Product Details

11585-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 7 publications 7 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SRP68 Fusion Protein Ag2177 (262-596 aa encoded by BC020238)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSEVEWRGR TVPVKIDKVR IFLLGLADNE AAIVQAESEE TKERLFESML SECRDAIQVV REELKPDQKQ RDYILEGEPG KVSNLQYLHS YLTYIKLSTA IKRNENMAKG LQRALLQQQP EDDSKRSPRP QDLIRLYDII LQNLVELLQL PGLEEDKAFQ KEIGLKTLVF KAYRCFFIAQ SYVLVKKWSE ALVLYDRVLK YANEVNSDAG AFKNSLKDLP DVQELITQVR SEKCSLQAAA ILDANDAHQT ETSSSQVKDN KPLVERFETF CLDPSLVTKQ ANLVHFPPGF QPIPCKPLFF DLALNHVAFP PLEDKLEQKT KSGLTGYIKG IFGFRS (262-596 aa encoded by BC020238)

Target Information

The signal recognition particle (SRP) is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits. SRP68 is the 68kDa component of the SRP.The signal recognition particle (SRP) is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits. This gene encodes the 68kDa component of the SRP. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The pioneer round of translation ensures proper targeting of ER and mitochondrial proteins.

Nucleic acids research

Park J,Chang J,Hwang HJ,Jeong K,Lee HJ,Ha H,Park Y,Lim C,Woo JS,Kim YK

Thu Dec 02 00:00:00 UTC 2021

The Perlman syndrome DIS3L2 exoribonuclease safeguards endoplasmic reticulum-targeted mRNA translation and calcium ion homeostasis.

Nature communications

Pirouz M,Wang CH,Liu Q,Ebrahimi AG,Shamsi F,Tseng YH,Gregory RI

Tue May 26 00:00:00 UTC 2020

The CELF1 RNA-Binding Protein Regulates Decay of Signal Recognition Particle mRNAs and Limits Secretion in Mouse Myoblasts.

PloS one

Russo J,Lee JE,López CM,Anderson J,Nguyen TP,Heck AM,Wilusz J,Wilusz CJ

Mon Aug 14 00:00:00 UTC 2017

The CELF1 RNA-Binding Protein Regulates Decay of Signal Recognition Particle mRNAs and Limits Secretion in Mouse Myoblasts.

PloS one

Russo J,Lee JE,López CM,Anderson J,Nguyen TP,Heck AM,Wilusz J,Wilusz CJ

Mon Aug 14 00:00:00 UTC 2017

Protein Hit1, a novel box C/D snoRNP assembly factor, controls cellular concentration of the scaffolding protein Rsa1 by direct interaction.

Nucleic acids research

Rothé B,Saliou JM,Quinternet M,Back R,Tiotiu D,Jacquemin C,Loegler C,Schlotter F,Peña V,Eckert K,Moréra S,Dorsselaer AV,Branlant C,Massenet S,Sanglier-Cianférani S,Manival X,Charpentier B

Tue Jan 20 00:00:00 UTC 2015

Protein Hit1, a novel box C/D snoRNP assembly factor, controls cellular concentration of the scaffolding protein Rsa1 by direct interaction.

Nucleic acids research

Rothé B,Saliou JM,Quinternet M,Back R,Tiotiu D,Jacquemin C,Loegler C,Schlotter F,Peña V,Eckert K,Moréra S,Dorsselaer AV,Branlant C,Massenet S,Sanglier-Cianférani S,Manival X,Charpentier B

Tue Jan 20 00:00:00 UTC 2015

Implication of the SMN complex in the biogenesis and steady state level of the signal recognition particle.

Nucleic acids research

Piazzon N,Schlotter F,Lefebvre S,Dodré M,Méreau A,Soret J,Besse A,Barkats M,Bordonné R,Branlant C,Massenet S

Tue Jan 01 00:00:00 UTC 2013

Implication of the SMN complex in the biogenesis and steady state level of the signal recognition particle.

Nucleic acids research

Piazzon N,Schlotter F,Lefebvre S,Dodré M,Méreau A,Soret J,Besse A,Barkats M,Bordonné R,Branlant C,Massenet S

Tue Jan 01 00:00:00 UTC 2013

Effects of 1.8 GHz radiofrequency radiation on protein expression in human lens epithelial cells.

Human & experimental toxicology

Zhang Y,Yao K,Yu Y,Ni S,Zhang L,Wang W,Lai K

Thu Aug 01 00:00:00 UTC 2013

Effects of 1.8 GHz radiofrequency radiation on protein expression in human lens epithelial cells.

Human & experimental toxicology

Zhang Y,Yao K,Yu Y,Ni S,Zhang L,Wang W,Lai K

Thu Aug 01 00:00:00 UTC 2013

Decreased dicer expression enhances SRP-mediated protein targeting.

PloS one

Ren YF,Li G,Xue YF,Zhang XJ,Song YJ,Lv L,Wu J,Fang YX,Wang YQ,Shi KQ,Chen YP,Tang KF

Fri Aug 23 00:00:00 UTC 2013

Decreased dicer expression enhances SRP-mediated protein targeting.

PloS one

Ren YF,Li G,Xue YF,Zhang XJ,Song YJ,Lv L,Wu J,Fang YX,Wang YQ,Shi KQ,Chen YP,Tang KF

Fri Aug 23 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: likely ortholog of H. sapiens signal recognition particle 68kDa (SRP68); Signal recognition particle 68 kDa protein; signal recognition particle 68kD; signal recognition particle 68kDa; Signal recognition particle subunit SRP68; SRP68

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Gene Aliases: 2610024I03Rik; SRP68

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UniProt ID: (Human) Q9UHB9, (Mouse) Q8BMA6

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Entrez Gene ID: (Human) 6730, (Rat) 363707, (Mouse) 217337

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Function(s)

signal recognition particle binding protein binding 7S RNA binding endoplasmic reticulum signal peptide binding poly(A) RNA binding signal sequence binding RNA binding

Process(es)

SRP-dependent cotranslational protein targeting to membrane response to drug protein targeting to ER

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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SRP68 Polyclonal Antibody

SRP68 Antibody (11585-1-AP) in ICC/IF

Product Details

11585-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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