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Invitrogen
SRPX Polyclonal Antibody
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SRPX Antibody (PA5-116545) in IHC (P)
Immunohistochemistry analysis of SRPX in paraffin-embedded mouse kidney. Samples were incubated with SRPX Polyclonal antibody (Product # PA5-116545) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-116545
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 40-320 of human SRPX (NP_0062981)
Conjugate
Form
Liquid
Concentration
1.98 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2901176
Product Specific Information
Positive Samples: Mouse heart, Mouse liver
Immunogen sequence: EDDEVGYSHP RYKDTPWCSP IKVKYGDVYC RAPQGGYYKT ALGTRCDIRC QKGYELHGSS LLICQSNKRW SDKVICKQKR CPTLAMPANG GFKCVDGAYF NSRCEYYCSP GYTLKGERTV TCMDNKAWSG RPASCVDMEP PRIKCPSVKE RIAEPNKLTV RVSWETPEGR DTADGILTDV ILKGLPPGSN FPEGDHKIQY TVYDRAENKG TCKFRVKVRV KRCGKLNAPE NGYMKCSSDG DNYGATCEFS CIGGYELQGS PARVCQSNLA WSGTEPTCAA M
Target Information
SRPX1 was initially identified as a candidate gene for X-linked retinitis pigmentosa and is overexpressed in the trabecular network of the eye in glaucoma conditions. Its expression is significantly downregulated in a number cancer cell lines and malignant tumor tissues and its ectopic expression induces apoptosis through the endoplasmic reticulum and the activation of caspase-12, -9, and -3, indicating that it can function as a tumor suppressor. SRPX1 is also involved with the regulation of autophagy under low serum conditions and can associate with Rab24, a member of the Rab GTPase protein family that is involved in autophagy. This association of SRPX1 with Rab24 is enhanced during autophagy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DRS protein; Sushi-repeat-containing protein SRPX; sushi-repeat-containing protein, X chromosome; sushi-repeat-containing protein, X-chromosome
Gene Aliases: drs; drs-1; drs-2; mDRS-1; mDRS-2; Srpx
UniProt ID: (Mouse) Q9R0M3
Entrez Gene ID: (Mouse) 51795
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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