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Product Details
PA5-75246
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 50-100 of Human SRY.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2718974
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: essential protein for sex determination in human males; HMG box transcription factor Sry1; HMG box transcription factor Sry3BI; sex determining region of Chr Y; sex determining region on Y; sex determining region Y protein; sex-determining region on Y; Sex-determining region Y protein; Testis determining locus; testis determining-Y; Testis-determining factor; testis-determining factor on Y
Gene Aliases: SRXX1; SRXY1; SRY; Sry1; Sry3BI; SRYGENE; TDF; TDY
UniProt ID: (Human) Q05066, (Mouse) Q05738
Entrez Gene ID: (Human) 6736, (Mouse) 21674, (Rat) 25221
DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
calmodulin binding
transcription factor binding
DNA binding, bending
protein heterodimerization activity
RNA polymerase II transcription factor activity, sequence-specific DNA binding
protein binding
enzyme binding
sequence-specific DNA binding
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
male gonad development
cell differentiation
male sex determination
positive regulation of transcription, DNA-templated
positive regulation of male gonad development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
sex determination
sex differentiation
negative regulation of gene expression
positive regulation of transcription from RNA polymerase II promoter
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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