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Proteintech
SRY Monoclonal Antibody (2E9A4)
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Product Details
67349-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2E9A4
Immunogen
SRY Fusion Protein Ag12610
Conjugate
Form
Liquid
Concentration
1000 µg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: essential protein for sex determination in human males; HMG box transcription factor Sry1; HMG box transcription factor Sry3BI; sex determining region of Chr Y; sex determining region on Y; sex determining region Y protein; sex-determining region on Y; Sex-determining region Y protein; Testis determining locus; Testis-determining factor; testis-determining factor on Y
Gene Aliases: SRXX1; SRXY1; SRY; Sry1; Sry3BI; SRYGENE; TDF; TDY
UniProt ID: (Human) Q05066
Entrez Gene ID: (Human) 6736, (Rat) 25221
DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
calmodulin binding
transcription factor binding
DNA binding, bending
protein heterodimerization activity
RNA polymerase II transcription factor activity, sequence-specific DNA binding
enzyme binding
sequence-specific DNA binding
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
male gonad development
cell differentiation
male sex determination
positive regulation of transcription, DNA-templated
positive regulation of male gonad development
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
sex determination
sex differentiation
negative regulation of gene expression
positive regulation of transcription from RNA polymerase II promoter
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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