Product References
Identification of chemotherapy targets reveals a nucleus-to-mitochondria ROS sensing pathway.
bioRxiv : the preprint server for biology
Zhang J,Simpson CM,Berner J,Chong HB,Fang J,Sahin ZO,Weiss-Sadan T,Possemato AP,Harry S,Takahashi M,Yang TY,Richter M,Patel H,Smith AE,Carlin AD,Hubertus de Groot AF,Wolf K,Shi L,Wei TY,Dürr BR,Chen NJ,Vornbäumen T,Wichmann NO,Pooladanda V,Matoba Y,Kumar S,Kim E,Bouberhan S,Olivia E,Rueda B,Bardeesy N,Liau B,Lawrence M,Stokes MP,Beausoleil SA,Bar-Peled L
Sat Mar 11 00:00:00 UTC 2023
Evaluation of mitochondrial biogenesis and ROS generation in high-grade serous ovarian cancer.
Frontiers in oncology
Koc ZC,Sollars VE,Bou Zgheib N,Rankin GO,Koc EC
Tue Mar 21 00:00:00 UTC 2023
Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway.
Cell
Zhang J,Simpson CM,Berner J,Chong HB,Fang J,Ordulu Z,Weiss-Sadan T,Possemato AP,Harry S,Takahashi M,Yang TY,Richter M,Patel H,Smith AE,Carlin AD,Hubertus de Groot AF,Wolf K,Shi L,Wei TY,Dürr BR,Chen NJ,Vornbäumen T,Wichmann NO,Mahamdeh MS,Pooladanda V,Matoba Y,Kumar S,Kim E,Bouberhan S,Oliva E,Rueda BR,Soberman RJ,Bardeesy N,Liau BB,Lawrence M,Stokes MP,Beausoleil SA,Bar-Peled L
Thu May 25 00:00:00 UTC 2023
REC drives recombination to repair double-strand breaks in animal mtDNA.
The Journal of cell biology
Klucnika A,Mu P,Jezek J,McCormack M,Di Y,Bradshaw CR,Ma H
Mon Jan 02 00:00:00 UTC 2023
A deafness-associated mitochondrial DNA mutation caused pleiotropic effects on DNA replication and tRNA metabolism.
Nucleic acids research
Meng F,Jia Z,Zheng J,Ji Y,Wang J,Xiao Y,Fu Y,Wang M,Ling F,Guan MX
Fri Sep 09 00:00:00 UTC 2022
A Method for In Situ Reverse Genetic Analysis of Proteins Involved mtDNA Replication.
Cells
Kozhukhar N,Spadafora D,Rodriguez YAR,Alexeyev MF
Mon Jul 11 00:00:00 UTC 2022
Top3α is the replicative topoisomerase in mitochondrial DNA replication.
Nucleic acids research
Hangas A,Kekäläinen NJ,Potter A,Michell C,Aho KJ,Rutanen C,Spelbrink JN,Pohjoismäki JL,Goffart S
Fri Aug 26 00:00:00 UTC 2022
The mitochondrial single-stranded DNA binding protein is essential for initiation of mtDNA replication.
Science advances
Jiang M,Xie X,Zhu X,Jiang S,Milenkovic D,Misic J,Shi Y,Tandukar N,Li X,Atanassov I,Jenninger L,Hoberg E,Albarran-Gutierrez S,Szilagyi Z,Macao B,Siira SJ,Carelli V,Griffith JD,Gustafsson CM,Nicholls TJ,Filipovska A,Larsson NG,Falkenberg M
Thu Jul 01 00:00:00 UTC 2021
LONP1 and ClpP cooperatively regulate mitochondrial proteostasis for cancer cell survival.
Oncogenesis
Lee YG,Kim HW,Nam Y,Shin KJ,Lee YJ,Park DH,Rhee HW,Seo JK,Chae YC
Fri Feb 26 00:00:00 UTC 2021
The FASTK family proteins fine-tune mitochondrial RNA processing.
PLoS genetics
Ohkubo A,Van Haute L,Rudler DL,Stentenbach M,Steiner FA,Rackham O,Minczuk M,Filipovska A,Martinou JC
Mon Nov 01 00:00:00 UTC 2021
The circular RNA circZFR phosphorylates Rb promoting cervical cancer progression by regulating the SSBP1/CDK2/cyclin E1 complex.
Journal of experimental & clinical cancer research : CR
Zhou M,Yang Z,Wang D,Chen P,Zhang Y
Sat Jan 30 00:00:00 UTC 2021
The circular RNA circZFR phosphorylates Rb promoting cervical cancer progression by regulating the SSBP1/CDK2/cyclin E1 complex.
Journal of experimental & clinical cancer research : CR
Zhou M,Yang Z,Wang D,Chen P,Zhang Y
Sat Jan 30 00:00:00 UTC 2021
Mitochondrial RNA granules are fluid condensates positioned by membrane dynamics.
Nature cell biology
Rey T,Zaganelli S,Cuillery E,Vartholomaiou E,Croisier M,Martinou JC,Manley S
Thu Oct 01 00:00:00 UTC 2020
Mitochondrial single-stranded DNA binding protein novel de novo SSBP1 mutation in a child with single large-scale mtDNA deletion (SLSMD) clinically manifesting as Pearson, Kearns-Sayre, and Leigh syndromes.
PloS one
Gustafson MA,McCormick EM,Perera L,Longley MJ,Bai R,Kong J,Dulik M,Shen L,Goldstein AC,McCormack SE,Laskin BL,Leroy BP,Ortiz-Gonzalez XR,Ellington MG,Copeland WC,Falk MJ
Mon Mar 16 00:00:00 UTC 2020
Heterozygous SSBP1 start loss mutation co-segregates with hearing loss and the m.1555A>G mtDNA variant in a large multigenerational family.
Brain : a journal of neurology
Kullar PJ,Gomez-Duran A,Gammage PA,Garone C,Minczuk M,Golder Z,Wilson J,Montoya J,Häkli S,Kärppä M,Horvath R,Majamaa K,Chinnery PF
Mon Jan 01 00:00:00 UTC 2018
Heterozygous SSBP1 start loss mutation co-segregates with hearing loss and the m.1555A>G mtDNA variant in a large multigenerational family.
Brain : a journal of neurology
Kullar PJ,Gomez-Duran A,Gammage PA,Garone C,Minczuk M,Golder Z,Wilson J,Montoya J,Häkli S,Kärppä M,Horvath R,Majamaa K,Chinnery PF
Mon Jan 01 00:00:00 UTC 2018
Utilizing Optimized Tools to Investigate PTM Crosstalk: Identifying Potential PTM Crosstalk of Acetylated Mitochondrial Proteins.
Proteomes
Horita H,Law A,Middleton K
Tue May 22 00:00:00 UTC 2018
Utilizing Optimized Tools to Investigate PTM Crosstalk: Identifying Potential PTM Crosstalk of Acetylated Mitochondrial Proteins.
Proteomes
Horita H,Law A,Middleton K
Tue May 22 00:00:00 UTC 2018
Single-Molecule Analysis of mtDNA Replication Uncovers the Basis of the Common Deletion.
Molecular cell
Phillips AF,Millet AR,Tigano M,Dubois SM,Crimmins H,Babin L,Charpentier M,Piganeau M,Brunet E,Sfeir A
Thu Feb 02 00:00:00 UTC 2017
Single-Molecule Analysis of mtDNA Replication Uncovers the Basis of the Common Deletion.
Molecular cell
Phillips AF,Millet AR,Tigano M,Dubois SM,Crimmins H,Babin L,Charpentier M,Piganeau M,Brunet E,Sfeir A
Thu Feb 02 00:00:00 UTC 2017
PrimPol is required for replication reinitiation after mtDNA damage.
Proceedings of the National Academy of Sciences of the United States of America
Torregrosa-Muñumer R,Forslund JME,Goffart S,Pfeiffer A,Stojkovič G,Carvalho G,Al-Furoukh N,Blanco L,Wanrooij S,Pohjoismäki JLO
Tue Oct 24 00:00:00 UTC 2017
PrimPol is required for replication reinitiation after mtDNA damage.
Proceedings of the National Academy of Sciences of the United States of America
Torregrosa-Muñumer R,Forslund JME,Goffart S,Pfeiffer A,Stojkovič G,Carvalho G,Al-Furoukh N,Blanco L,Wanrooij S,Pohjoismäki JLO
Tue Oct 24 00:00:00 UTC 2017
Downregulation of Mitochondrial Single Stranded DNA Binding Protein (SSBP1) Induces Mitochondrial Dysfunction and Increases the Radiosensitivity in Non-Small Cell Lung Cancer Cells.
Journal of Cancer
Wang Y,Hu L,Zhang X,Zhao H,Xu H,Wei Y,Jiang H,Xie C,Zhou Y,Zhou F
Thu Oct 01 00:00:00 UTC 2020
Downregulation of Mitochondrial Single Stranded DNA Binding Protein (SSBP1) Induces Mitochondrial Dysfunction and Increases the Radiosensitivity in Non-Small Cell Lung Cancer Cells.
Journal of Cancer
Wang Y,Hu L,Zhang X,Zhao H,Xu H,Wei Y,Jiang H,Xie C,Zhou Y,Zhou F
Thu Oct 01 00:00:00 UTC 2020
Tenofovir and adefovir down-regulate mitochondrial chaperone TRAP1 and succinate dehydrogenase subunit B to metabolically reprogram glucose metabolism and induce nephrotoxicity.
Scientific reports
Zhao X,Sun K,Lan Z,Song W,Cheng L,Chi W,Chen J,Huo Y,Xu L,Liu X,Deng H,Siegenthaler JA,Chen L
Tue Apr 11 00:00:00 UTC 2017
Tenofovir and adefovir down-regulate mitochondrial chaperone TRAP1 and succinate dehydrogenase subunit B to metabolically reprogram glucose metabolism and induce nephrotoxicity.
Scientific reports
Zhao X,Sun K,Lan Z,Song W,Cheng L,Chi W,Chen J,Huo Y,Xu L,Liu X,Deng H,Siegenthaler JA,Chen L
Tue Apr 11 00:00:00 UTC 2017
MOF Acetyl Transferase Regulates Transcription and Respiration in Mitochondria.
Cell
Chatterjee A,Seyfferth J,Lucci J,Gilsbach R,Preissl S,Böttinger L,Mårtensson CU,Panhale A,Stehle T,Kretz O,Sahyoun AH,Avilov S,Eimer S,Hein L,Pfanner N,Becker T,Akhtar A
Thu Oct 20 00:00:00 UTC 2016
MOF Acetyl Transferase Regulates Transcription and Respiration in Mitochondria.
Cell
Chatterjee A,Seyfferth J,Lucci J,Gilsbach R,Preissl S,Böttinger L,Mårtensson CU,Panhale A,Stehle T,Kretz O,Sahyoun AH,Avilov S,Eimer S,Hein L,Pfanner N,Becker T,Akhtar A
Thu Oct 20 00:00:00 UTC 2016
Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization.
Cell death and differentiation
Li H,Ruan Y,Zhang K,Jian F,Hu C,Miao L,Gong L,Sun L,Zhang X,Chen S,Chen H,Liu D,Song Z
Tue Mar 01 00:00:00 UTC 2016
Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization.
Cell death and differentiation
Li H,Ruan Y,Zhang K,Jian F,Hu C,Miao L,Gong L,Sun L,Zhang X,Chen S,Chen H,Liu D,Song Z
Tue Mar 01 00:00:00 UTC 2016
In vivo occupancy of mitochondrial single-stranded DNA binding protein supports the strand displacement mode of DNA replication.
PLoS genetics
Miralles Fusté J,Shi Y,Wanrooij S,Zhu X,Jemt E,Persson Ö,Sabouri N,Gustafsson CM,Falkenberg M
Mon Dec 01 00:00:00 UTC 2014
In vivo occupancy of mitochondrial single-stranded DNA binding protein supports the strand displacement mode of DNA replication.
PLoS genetics
Miralles Fusté J,Shi Y,Wanrooij S,Zhu X,Jemt E,Persson Ö,Sabouri N,Gustafsson CM,Falkenberg M
Mon Dec 01 00:00:00 UTC 2014
In vivo occupancy of mitochondrial single-stranded DNA binding protein supports the strand displacement mode of DNA replication.
PLoS genetics
Miralles Fusté J,Shi Y,Wanrooij S,Zhu X,Jemt E,Persson Ö,Sabouri N,Gustafsson CM,Falkenberg M
Mon Dec 01 00:00:00 UTC 2014
In vivo occupancy of mitochondrial single-stranded DNA binding protein supports the strand displacement mode of DNA replication.
PLoS genetics
Miralles Fusté J,Shi Y,Wanrooij S,Zhu X,Jemt E,Persson Ö,Sabouri N,Gustafsson CM,Falkenberg M
Mon Dec 01 00:00:00 UTC 2014
