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Product Details
H00054434-M02-100
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
1D2
Immunogen
SSH1 (NP_061857.2, 950 a.a. approximately 1049 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: LVKQRTQEIE TRLRLAGLTV SSPLKRSHSL AKLGSLTFST EDLSSEADPS TVADSQDTTL SESSFLHEPQ GTPRDPAATS KPSGKPAPEN LKSPSWMSKS
Target Information
This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hSSH-1L; Protein phosphatase Slingshot homolog 1; slingshot homolog 1; SSH-1L; SSH-like protein 1
Gene Aliases: KIAA1298; SSH1; SSH1L
UniProt ID: (Human) Q8WYL5
Entrez Gene ID: (Human) 54434
cell morphogenesis
protein dephosphorylation
regulation of actin polymerization or depolymerization
regulation of lamellipodium assembly
actin cytoskeleton organization
regulation of cellular protein metabolic process
peptidyl-tyrosine dephosphorylation
regulation of axonogenesis
cellular response to ATP
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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