Proteintech

ST6GAL1 Polyclonal Antibody

ST6GAL1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ST6GAL1 Antibody (14355-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using 14355-1-AP (ST6GAL1 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

ST6GAL1 Antibody in Flow Cytometry (Flow)

ST6GAL1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

14355-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 7 publications 7 publications

Immunohistochemistry (IHC)

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Flow Cytometry (Flow)

Assay-dependent

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ST6GAL1 Fusion Protein Ag5705 (60-406 aa encoded by BC040009)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Western blot analysis of human liver using this antibody detects both isoforms between 43-50 kDa. Higher molecular weight of bands around 50-70 kDa can also be observed with unknown reason.

Immunogen sequence: SQSVSSSST QDPHRGRQTL GSLRGLAKAK PEASFQVWNK DSSSKNLIPR LQKIWKNYLS MNKYKVSYKG PGPGIKFSAE ALRCHLRDHV NVSMVEVTDF PFNTSEWEGY LPKESIRTKA GPWGRCAVVS SAGSLKSSQL GREIDDHDAV LRFNGAPTAN FQQDVGTKTT IRLMNSQLVT TEKRFLKDSL YNEGILIVWD PSVYHSDIPK WYQNPDYNFF NNYKTYRKLH PNQPFYILKP QMPWELWDIL QEISPEEIQP NPPSSGMLGI IIMMTLCDQV DIYEFLPSKR KTDVCYYYQK FFDSACTMGA YHPLLYEKNL VKHLNQGTDE DIYLLGKATL PGFRTIHC (60-406 aa encoded by BC040009 )

Target Information

The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein, which is normally found in the Golgi but which can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CDw75, and CD76. This protein is a member of glycosyltransferase family 29. Three transcript variants encoding two different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Immune checkpoint therapy-elicited sialylation of IgG antibodies impairs antitumorigenic type I interferon responses in hepatocellular carcinoma.

Immunity

Wu RQ,Lao XM,Chen DP,Qin H,Mu M,Cao WJ,Deng J,Wan CC,Zhan WY,Wang JC,Xu L,Chen MS,Gao Q,Zheng L,Wei Y,Kuang DM

Tue Jan 10 00:00:00 UTC 2023

Immune checkpoint therapy-elicited sialylation of IgG antibodies impairs antitumorigenic type I interferon responses in hepatocellular carcinoma.

Immunity

Wu RQ,Lao XM,Chen DP,Qin H,Mu M,Cao WJ,Deng J,Wan CC,Zhan WY,Wang JC,Xu L,Chen MS,Gao Q,Zheng L,Wei Y,Kuang DM

Tue Jan 10 00:00:00 UTC 2023

Immune checkpoint therapy-elicited sialylation of IgG antibodies impairs antitumorigenic type I interferon responses in hepatocellular carcinoma.

Immunity

Wu RQ,Lao XM,Chen DP,Qin H,Mu M,Cao WJ,Deng J,Wan CC,Zhan WY,Wang JC,Xu L,Chen MS,Gao Q,Zheng L,Wei Y,Kuang DM

Tue Jan 10 00:00:00 UTC 2023

Immune checkpoint therapy-elicited sialylation of IgG antibodies impairs antitumorigenic type I interferon responses in hepatocellular carcinoma.

Immunity

Wu RQ,Lao XM,Chen DP,Qin H,Mu M,Cao WJ,Deng J,Wan CC,Zhan WY,Wang JC,Xu L,Chen MS,Gao Q,Zheng L,Wei Y,Kuang DM

Tue Jan 10 00:00:00 UTC 2023

Downregulation of ST6GAL1 Promotes Liver Inflammation and Predicts Adverse Prognosis in Hepatocellular Carcinoma.

Journal of inflammation research

Liu R,Cao X,Liang Y,Li X,Jin Q,Li Y,Du H,Zao X,Ye Y

Sat Feb 04 00:00:00 UTC 2023

Downregulation of ST6GAL1 Promotes Liver Inflammation and Predicts Adverse Prognosis in Hepatocellular Carcinoma.

Journal of inflammation research

Liu R,Cao X,Liang Y,Li X,Jin Q,Li Y,Du H,Zao X,Ye Y

Sat Feb 04 00:00:00 UTC 2023

Downregulation of ST6GAL1 Promotes Liver Inflammation and Predicts Adverse Prognosis in Hepatocellular Carcinoma.

Journal of inflammation research

Liu R,Cao X,Liang Y,Li X,Jin Q,Li Y,Du H,Zao X,Ye Y

Sat Feb 04 00:00:00 UTC 2023

Downregulation of ST6GAL1 Promotes Liver Inflammation and Predicts Adverse Prognosis in Hepatocellular Carcinoma.

Journal of inflammation research

Liu R,Cao X,Liang Y,Li X,Jin Q,Li Y,Du H,Zao X,Ye Y

Sat Feb 04 00:00:00 UTC 2023

Long noncoding RNA TINCR facilitates hepatocellular carcinoma progression and dampens chemosensitivity to oxaliplatin by regulating the miR-195-3p/ST6GAL1/NF-κB pathway.

Journal of experimental & clinical cancer research : CR

Mei J,Lin W,Li S,Tang Y,Ye Z,Lu L,Wen Y,Kan A,Zou J,Yu C,Wei W,Guo R

Mon Jan 03 00:00:00 UTC 2022

Long noncoding RNA TINCR facilitates hepatocellular carcinoma progression and dampens chemosensitivity to oxaliplatin by regulating the miR-195-3p/ST6GAL1/NF-κB pathway.

Journal of experimental & clinical cancer research : CR

Mei J,Lin W,Li S,Tang Y,Ye Z,Lu L,Wen Y,Kan A,Zou J,Yu C,Wei W,Guo R

Mon Jan 03 00:00:00 UTC 2022

Caveolin-1 facilitates cell migration by upregulating nuclear receptor 4A2/retinoid X receptor α-mediated β-galactoside α2,6-sialyltransferase I expression in human hepatocarcinoma cells.

The international journal of biochemistry & cell biology

Chen X,Wang L,Yu X,Wang S,Zhang J

Sun Aug 01 00:00:00 UTC 2021

Integrated Systems Analysis of the Murine and Human Pancreatic Cancer Glycomes Reveals a Tumor-Promoting Role for ST6GAL1.

Molecular & cellular proteomics : MCP

Kurz E,Chen S,Vucic E,Baptiste G,Loomis C,Agrawal P,Hajdu C,Bar-Sagi D,Mahal LK

Thu Mar 24 00:00:00 UTC 2022

Integrated Systems Analysis of the Murine and Human Pancreatic Cancer Glycomes Reveals a Tumor-Promoting Role for ST6GAL1.

Molecular & cellular proteomics : MCP

Kurz E,Chen S,Vucic E,Baptiste G,Loomis C,Agrawal P,Hajdu C,Bar-Sagi D,Mahal LK

Thu Mar 24 00:00:00 UTC 2022

Integrated Systems Analysis of the Murine and Human Pancreatic Cancer Glycomes Reveals a Tumor-Promoting Role for ST6GAL1.

Molecular & cellular proteomics : MCP

Kurz E,Chen S,Vucic E,Baptiste G,Loomis C,Agrawal P,Hajdu C,Bar-Sagi D,Mahal LK

Thu Mar 24 00:00:00 UTC 2022

Integrated Systems Analysis of the Murine and Human Pancreatic Cancer Glycomes Reveals a Tumor-Promoting Role for ST6GAL1.

Molecular & cellular proteomics : MCP

Kurz E,Chen S,Vucic E,Baptiste G,Loomis C,Agrawal P,Hajdu C,Bar-Sagi D,Mahal LK

Thu Mar 24 00:00:00 UTC 2022

High-Risk HPV16 E6 Activates the cGMP/PKG Pathway Through Glycosyltransferase ST6GAL1 in Cervical Cancer Cells.

Frontiers in oncology

Wang J,Liu G,Liu M,Cai Q,Yao C,Chen H,Song N,Yuan C,Tan D,Hu Y,Xiang Y,Xiang T

Wed Nov 08 00:00:00 UTC 2023

α1,6-Fucosyltransferase (FUT8) regulates the cancer-promoting capacity of cancer-associated fibroblasts (CAFs) by modifying EGFR core fucosylation (CF) in non-small cell lung cancer (NSCLC).

American journal of cancer research

Li F,Zhao S,Cui Y,Guo T,Qiang J,Xie Q,Yu W,Guo W,Deng W,Gu C,Wu T

Mon Sep 28 00:00:00 UTC 2020

Alginate oligosaccharide attenuates α2,6-sialylation modification to inhibit prostate cancer cell growth via the Hippo/YAP pathway.

Cell death & disease

Han Y,Zhang L,Yu X,Wang S,Xu C,Yin H,Wang S

Fri May 10 00:00:00 UTC 2019

Alginate oligosaccharide attenuates α2,6-sialylation modification to inhibit prostate cancer cell growth via the Hippo/YAP pathway.

Cell death & disease

Han Y,Zhang L,Yu X,Wang S,Xu C,Yin H,Wang S

Fri May 10 00:00:00 UTC 2019

Modification of α2,6-sialylation mediates the invasiveness and tumorigenicity of non-small cell lung cancer cells in vitro and in vivo via Notch1/Hes1/MMPs pathway.

International journal of cancer

Yuan Q,Chen X,Han Y,Lei T,Wu Q,Yu X,Wang L,Fan Z,Wang S

Thu Nov 01 00:00:00 UTC 2018

Modification of α2,6-sialylation mediates the invasiveness and tumorigenicity of non-small cell lung cancer cells in vitro and in vivo via Notch1/Hes1/MMPs pathway.

International journal of cancer

Yuan Q,Chen X,Han Y,Lei T,Wu Q,Yu X,Wang L,Fan Z,Wang S

Thu Nov 01 00:00:00 UTC 2018

Modification of α2,6-sialylation mediates the invasiveness and tumorigenicity of non-small cell lung cancer cells in vitro and in vivo via Notch1/Hes1/MMPs pathway.

International journal of cancer

Yuan Q,Chen X,Han Y,Lei T,Wu Q,Yu X,Wang L,Fan Z,Wang S

Thu Nov 01 00:00:00 UTC 2018

Modification of α2,6-sialylation mediates the invasiveness and tumorigenicity of non-small cell lung cancer cells in vitro and in vivo via Notch1/Hes1/MMPs pathway.

International journal of cancer

Yuan Q,Chen X,Han Y,Lei T,Wu Q,Yu X,Wang L,Fan Z,Wang S

Thu Nov 01 00:00:00 UTC 2018

Bioinformatics

Protein Aliases: Alpha 2,6-ST 1; B-cell antigen CD75; beta galactoside alpha 2,6 sialyltransferase 1; Beta-galactoside alpha-2,6-sialyltransferase 1; CMP-N-acetylneuraminate beta-galactosamide alpha-2,6-sialyltransferase; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1; Sialyltransferase 1; sialyltransferase 1 (beta-galactoside alpha-2,6-sialyltransferase); Sialyltransferase 1 (beta-galactoside alpha-2,6-sialytransferase); Sialyltransferase 1 (beta-galactoside alpha-26-sialytransferase); ST6 beta-galactosamide alpha-2,6-sialyltranferase 1; ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6Gal I; ST6GalI

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Gene Aliases: AW742324; SIAT1; St6gal; St6Gal-I; ST6GAL1; ST6GalI; ST6N

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UniProt ID: (Human) P15907, (Mouse) Q64685, (Rat) P13721

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Entrez Gene ID: (Human) 6480, (Mouse) 20440, (Rat) 25197

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Function(s)

beta-galactoside alpha-2,6-sialyltransferase activity protein binding sialyltransferase activity transferase activity transferase activity, transferring glycosyl groups

Process(es)

N-acetylneuraminate metabolic process protein glycosylation protein N-linked glycosylation via asparagine sialylation humoral immune response oligosaccharide metabolic process O-glycan processing positive regulation of mononuclear cell proliferation response to ethanol negative regulation of chemotaxis regulation of substrate adhesion-dependent cell spreading protein sialylation negative regulation of macrophage apoptotic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ST6GAL1 Polyclonal Antibody

ST6GAL1 Antibody (14355-1-AP) in IHC (P)

Product Details

14355-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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