Proteintech

STAM Polyclonal Antibody

STAM Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 8

STAM Antibody (12434-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol) fixed HepG2 cells using 12434-1-AP (STAM antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

STAM Antibody in Immunohistochemistry (Paraffin) (IHC (P))

STAM Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12434-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 14 publications 14 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

View 8 publications 8 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

STAM Fusion Protein Ag3112 (54-403 aa encoded by BC030586)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: VNHKDPHVA MQALTLLGAC VSNCGKIFHL EVCSRDFASE VSNVLNKGHP KVCEKLKALM VEWTDEFKND PQLSLISAMI KNLKEQGVTF PAIGSQAAEQ AKASPALVAK DPGTVANKKE EEDLAKAIEL SLKEQRQQST TLSTLYPSTS SLLTNHQHEG RKVRAIYDFE AAEDNELTFK AGEIITVLDD SDPNWWKGET HQGIGLFPSN FVTAYLTAEP EMIKTEKKTV QFSDDVQVET IEPEPEPAFI DEDKMDQLLQ MLQSTDPSDD QPDLPELLHL EAMCHQMGPL IDEKLEDIDR KHSELSELNV KVMEALSLYT KLMNEDPMYS MYAKLQNQPG SGPTIRKPSP S (54-403 aa encoded by BC030586)

Target Information

STAM (Signal transducing adaptor molecule) is an adaptor molecule involved in downstream signaling pathways mediated by growth factors and cytokines. STAM also plays an important role in endocytosis, the JAK-STAT signaling pathway, and membrane trafficking. In humans, the gene encoding STAM is located on chromosome 10.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Upregulation of the ESCRT pathway and multivesicular bodies accelerates degradation of proteins associated with neurodegeneration.

Autophagy reports

Benyair R,Giridharan SSP,Rivero-Ríos P,Hasegawa J,Bristow E,Eskelinen EL,Shmueli MD,Fishbain-Yoskovitz V,Merbl Y,Sharkey LM,Paulson HL,Hanson PI,Patnaik S,Al-Ramahi I,Botas J,Marugan J,Weisman LS

Wed Apr 19 00:00:00 UTC 2023

Proximity Labeling to Identify β-Arrestin1 Binding Partners Downstream of Ligand-Activated G Protein-Coupled Receptors.

International journal of molecular sciences

Zhuo Y,Robleto VL,Marchese A

Tue Feb 07 00:00:00 UTC 2023

A phosphoinositide signalling pathway mediates rapid lysosomal repair.

Nature

Tan JX,Finkel T

Thu Sep 01 00:00:00 UTC 2022

Endofin is required for HD-PTP and ESCRT-0 interdependent endosomal sorting of ubiquitinated transmembrane cargoes.

iScience

Kazan JM,Desrochers G,Martin CE,Jeong H,Kharitidi D,Apaja PM,Roldan A,St Denis N,Gingras AC,Lukacs GL,Pause A

Fri Nov 19 00:00:00 UTC 2021

A combined EM and proteomic analysis places HIV-1 Vpu at the crossroads of retromer and ESCRT complexes: PTPN23 is a Vpu-cofactor.

PLoS pathogens

Stoneham CA,Langer S,De Jesus PD,Wozniak JM,Lapek J,Deerinck T,Thor A,Pache L,Chanda SK,Gonzalez DJ,Ellisman M,Guatelli J

Mon Nov 01 00:00:00 UTC 2021

A combined EM and proteomic analysis places HIV-1 Vpu at the crossroads of retromer and ESCRT complexes: PTPN23 is a Vpu-cofactor.

PLoS pathogens

Stoneham CA,Langer S,De Jesus PD,Wozniak JM,Lapek J,Deerinck T,Thor A,Pache L,Chanda SK,Gonzalez DJ,Ellisman M,Guatelli J

Mon Nov 01 00:00:00 UTC 2021

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

Molecular cell

Zellner S,Schifferer M,Behrends C

Thu Mar 18 00:00:00 UTC 2021

Neuroprogenitor Cells From Patients With TBCK Encephalopathy Suggest Deregulation of Early Secretory Vesicle Transport.

Frontiers in cellular neuroscience

Moreira DP,Suzuki AM,Silva ALTE,Varella-Branco E,Meneghetti MCZ,Kobayashi GS,Fogo M,Ferrari MFR,Cardoso RR,Lourenço NCV,Griesi-Oliveira K,Zachi EC,Bertola DR,Weinmann KS,de Lima MA,Nader HB,Sertié AL,Passos-Bueno MR

Tue Feb 01 00:00:00 UTC 2022

A non-GPCR-binding partner interacts with a novel surface on β-arrestin1 to mediate GPCR signaling.

The Journal of biological chemistry

Zhuo Y,Gurevich VV,Vishnivetskiy SA,Klug CS,Marchese A

Fri Oct 09 00:00:00 UTC 2020

Endosomal membrane tension regulates ESCRT-III-dependent intra-lumenal vesicle formation.

Nature cell biology

Mercier V,Larios J,Molinard G,Goujon A,Matile S,Gruenberg J,Roux A

Sat Aug 01 00:00:00 UTC 2020

TIM-1 Ubiquitination Mediates Dengue Virus Entry.

Cell reports

Dejarnac O,Hafirassou ML,Chazal M,Versapuech M,Gaillard J,Perera-Lecoin M,Umana-Diaz C,Bonnet-Madin L,Carnec X,Tinevez JY,Delaugerre C,Schwartz O,Roingeard P,Jouvenet N,Berlioz-Torrent C,Meertens L,Amara A

Tue May 08 00:00:00 UTC 2018

TIM-1 Ubiquitination Mediates Dengue Virus Entry.

Cell reports

Tue May 08 00:00:00 UTC 2018

TIM-1 Ubiquitination Mediates Dengue Virus Entry.

Cell reports

Tue May 08 00:00:00 UTC 2018

TIM-1 Ubiquitination Mediates Dengue Virus Entry.

Cell reports

Tue May 08 00:00:00 UTC 2018

Identification of STAM1 as a novel effector of ventral projection of spinal motor neurons.

Development (Cambridge, England)

Nam H,Lee S

Fri Jul 01 00:00:00 UTC 2016

Identification of STAM1 as a novel effector of ventral projection of spinal motor neurons.

Development (Cambridge, England)

Nam H,Lee S

Fri Jul 01 00:00:00 UTC 2016

β-Arrestin1 and Signal-transducing Adaptor Molecule 1 (STAM1) Cooperate to Promote Focal Adhesion Kinase Autophosphorylation and Chemotaxis via the Chemokine Receptor CXCR4.

The Journal of biological chemistry

Alekhina O,Marchese A

Fri Dec 09 00:00:00 UTC 2016

β-Arrestin1 and Signal-transducing Adaptor Molecule 1 (STAM1) Cooperate to Promote Focal Adhesion Kinase Autophosphorylation and Chemotaxis via the Chemokine Receptor CXCR4.

The Journal of biological chemistry

Alekhina O,Marchese A

Fri Dec 09 00:00:00 UTC 2016

The α-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the β2-Adrenergic Receptor.

The Journal of biological chemistry

Tian X,Irannejad R,Bowman SL,Du Y,Puthenveedu MA,von Zastrow M,Benovic JL

Fri Jul 08 00:00:00 UTC 2016

The α-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the β2-Adrenergic Receptor.

The Journal of biological chemistry

Tian X,Irannejad R,Bowman SL,Du Y,Puthenveedu MA,von Zastrow M,Benovic JL

Fri Jul 08 00:00:00 UTC 2016

The α-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the β2-Adrenergic Receptor.

The Journal of biological chemistry

Tian X,Irannejad R,Bowman SL,Du Y,Puthenveedu MA,von Zastrow M,Benovic JL

Fri Jul 08 00:00:00 UTC 2016

The α-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the β2-Adrenergic Receptor.

The Journal of biological chemistry

Tian X,Irannejad R,Bowman SL,Du Y,Puthenveedu MA,von Zastrow M,Benovic JL

Fri Jul 08 00:00:00 UTC 2016

The endosomal sorting complex required for transport pathway mediates chemokine receptor CXCR4-promoted lysosomal degradation of the mammalian target of rapamycin antagonist DEPTOR.

The Journal of biological chemistry

Verma R,Marchese A

Fri Mar 13 00:00:00 UTC 2015

The endosomal sorting complex required for transport pathway mediates chemokine receptor CXCR4-promoted lysosomal degradation of the mammalian target of rapamycin antagonist DEPTOR.

The Journal of biological chemistry

Verma R,Marchese A

Fri Mar 13 00:00:00 UTC 2015

The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4.

Molecular biology of the cell

Holleman J,Marchese A

Sun Jun 15 00:00:00 UTC 2014

The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4.

Molecular biology of the cell

Holleman J,Marchese A

Sun Jun 15 00:00:00 UTC 2014

The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4.

Molecular biology of the cell

Holleman J,Marchese A

Sun Jun 15 00:00:00 UTC 2014

The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4.

Molecular biology of the cell

Holleman J,Marchese A

Sun Jun 15 00:00:00 UTC 2014

Novel roles for the E3 ubiquitin ligase atrophin-interacting protein 4 and signal transduction adaptor molecule 1 in G protein-coupled receptor signaling.

The Journal of biological chemistry

Malik R,Soh UJ,Trejo J,Marchese A

Fri Mar 16 00:00:00 UTC 2012

Novel roles for the E3 ubiquitin ligase atrophin-interacting protein 4 and signal transduction adaptor molecule 1 in G protein-coupled receptor signaling.

The Journal of biological chemistry

Malik R,Soh UJ,Trejo J,Marchese A

Fri Mar 16 00:00:00 UTC 2012

Novel roles for the E3 ubiquitin ligase atrophin-interacting protein 4 and signal transduction adaptor molecule 1 in G protein-coupled receptor signaling.

The Journal of biological chemistry

Malik R,Soh UJ,Trejo J,Marchese A

Fri Mar 16 00:00:00 UTC 2012

Novel roles for the E3 ubiquitin ligase atrophin-interacting protein 4 and signal transduction adaptor molecule 1 in G protein-coupled receptor signaling.

The Journal of biological chemistry

Malik R,Soh UJ,Trejo J,Marchese A

Fri Mar 16 00:00:00 UTC 2012

Arrestin-2 interacts with the endosomal sorting complex required for transport machinery to modulate endosomal sorting of CXCR4.

Molecular biology of the cell

Malik R,Marchese A

Thu Jul 15 00:00:00 UTC 2010

Arrestin-2 interacts with the endosomal sorting complex required for transport machinery to modulate endosomal sorting of CXCR4.

Molecular biology of the cell

Malik R,Marchese A

Thu Jul 15 00:00:00 UTC 2010

Arrestin-2 interacts with the endosomal sorting complex required for transport machinery to modulate endosomal sorting of CXCR4.

Molecular biology of the cell

Malik R,Marchese A

Thu Jul 15 00:00:00 UTC 2010

Arrestin-2 interacts with the endosomal sorting complex required for transport machinery to modulate endosomal sorting of CXCR4.

Molecular biology of the cell

Malik R,Marchese A

Thu Jul 15 00:00:00 UTC 2010

Bioinformatics

Protein Aliases: DKFZp686J2352; HSE1 homolog; Signal transducing adapter molecule 1; signal transducing adaptor molecule (SH3 domain and ITAM motif) 1; STAM-1; STAT91

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Gene Aliases: RGD1564499; STAM; STAM-1; STAM1

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UniProt ID: (Human) Q92783, (Mouse) P70297

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Entrez Gene ID: (Human) 8027, (Mouse) 20844, (Rat) 498798

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Function(s)

SH3/SH2 adaptor activity protein binding

Process(es)

transport intracellular protein transport protein transport positive regulation of exosomal secretion regulation of extracellular exosome assembly autophagy signal transduction positive regulation of signal transduction endosomal transport multivesicular body assembly negative regulation of epidermal growth factor receptor signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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STAM Polyclonal Antibody

STAM Antibody (12434-1-AP) in ICC/IF

Product Details

12434-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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