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Product Details
OSS00135G-500UG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from aa region 300-360 of the internal part of human STAM 1, 2 (STAM-1, STAM-2) conjugated to an immunogenic carrier protein was used as the immunogen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Purification
Ammonium sulfate precipitation
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
The antigen is homologous in many species including rat, mouse, zebra fish and xenopus.
Specificity of this antibody: STAM1 and 2.
Target Information
STAM1 is involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and c-myc induction. May also play a role in endocytic trafficking as well as in T-cell development. Subunit: Heterodimer. Composed of STAM1 and HGS/HRS. Also interacts directly with STAMBP/AMSH. Tissue Specificity: Ubiquitously expressed. STAM2 is involved in intracellular signal transduction mediated by cytokines and growth factors. Probably acts via its association with ubiquitinated cargo proteins on the early endosome participates in their sorting for trafficking to the lysosome. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and c-myc induction. May also play a in T-cell development. Subunit: Heterodimer or heterotrimer. At least composed of STAM2 and HGS/Hrs. EPS15 can be part of the complex. Interacts directly with STAMBP/AMSH, JAK2 and JAK3. Also interacts with ubiquitinated proteins and the deubiquitinating enzyme USP8/UBPY. Interacts directly with CBX5 via the PxVxL motif. Interacts with VPS37C. Tissue Specificity: Ubiquitously expressed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Hrs binding protein; Hrs-binding protein; HSE1 homolog; Signal transducing adapter molecule 1; Signal transducing adapter molecule 2; signal transducing adaptor molecule (SH3 domain and ITAM motif) 1; signal transducing adaptor molecule (SH3 domain and ITAM motif) 2; STAM-1; STAM-2; STAM-like protein containing SH3 and ITAM domains 2
Gene Aliases: 1200004O12Rik; 5730456G07Rik; BB145015; HBP; RGD1564499; STAM; STAM-1; STAM1; STAM2; STAM2A; STAM2B
UniProt ID: (Human) Q92783, (Human) O75886, (Mouse) P70297, (Rat) Q5XHY7, (Mouse) O88811
Entrez Gene ID: (Human) 8027, (Human) 10254, (Mouse) 20844, (Rat) 498798, (Rat) 311030, (Mouse) 56324
intracellular protein transport
transport
protein transport
positive regulation of exosomal secretion
regulation of extracellular exosome assembly
autophagy
endosomal transport
multivesicular body assembly
negative regulation of epidermal growth factor receptor signaling pathway
signal transduction
positive regulation of signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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