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Product Details
11346-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
STAMBP Fusion Protein Ag1895 (124-424 aa encoded by BC007682)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: EKKKEAEEL ARNMAIQQEL EKEKQRVAQQ KQQQLEQEQF HAFEEMIRNQ ELEKERLKIV QEFGKVDPGL GGPLVPDLEK PSLDVFPTLT VSSIQPSDCH TTVRPAKPPV VDRSLKPGAL SNSESIPTID GLRHVVVPGR LCPQFLQLAS ANTARGVETC GILCGKLMRN EFTITHVLIP KQSAGSDYCN TENEEELFLI QDQQGLITLG WIHTHPTQTA FLSSVDLHTH CSYQMMLPES VAIVCSPKFQ ETGFFKLTDH GLEEISSCRQ KGFHPHSKDP PLFCSCSHVT VVDRAVTITD LR (124-424 aa encoded by BC007682)
Target Information
Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Associated molecule with the SH3 domain of STAM; Endosome-associated ubiquitin isopeptidase; MGC126516; MGC126518; STAM-binding protein; testicular secretory protein Li 54
Gene Aliases: 5330424L14Rik; 5730422L11Rik; AMSH; AW107289; MICCAP; mKIAA4198; STAMBP
UniProt ID: (Human) O95630, (Rat) Q8R424, (Mouse) Q9CQ26
Entrez Gene ID: (Human) 10617, (Rat) 171565, (Mouse) 70527
mitotic cytokinesis
JAK-STAT cascade
positive regulation of cell proliferation
negative regulation of phosphatidylinositol 3-kinase signaling
protein deubiquitination
negative regulation of neuron apoptotic process
negative regulation of Ras protein signal transduction
proteolysis
biological_process
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