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Recommended positive controls: PC-3, U87-MG, NIH-3T3, JC, BCL-1.
Predicted reactivity: Mouse (81%), Rat (83%), Rhesus Monkey (98%), Bovine (88%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Associated molecule with the SH3 domain of STAM; Endosome-associated ubiquitin isopeptidase; MGC126516; MGC126518; STAM-binding protein; testicular secretory protein Li 54
Gene Aliases: 5330424L14Rik; 5730422L11Rik; AMSH; AW107289; MICCAP; mKIAA4198; STAMBP
UniProt ID: (Human) O95630, (Mouse) Q9CQ26
Entrez Gene ID: (Human) 10617, (Mouse) 70527
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