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          • Primary Antibodies ›
          • STAT5 alpha/beta Antibodies

          Bioss

          STAT5 Polyclonal Antibody

          View all (18) STAT5 alpha/beta antibodies

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          Cite STAT5 Polyclonal Antibody

          • Antibody Testing Data (3)
          STAT5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          STAT5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 3

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          STAT5 Antibody (BS-1142R) in IHC (P)

          Paraformaldehyde-fixed, paraffin embedded Human endometrial cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with STAT5 Polyclonal Antibody, Unconjugated (bs-1142R) at 1:200 overnight at 4°C, DAB staining. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          STAT5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          STAT5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          STAT5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

          Product Details

          BS-1142R

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:2,000
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          1:200
          -

          Immunohistochemistry (Frozen) (IHC (F))

          1:100-1:500
          -

          Immunocytochemistry (ICC/IF)

          1:50-1:200
          -

          ELISA (ELISA)

          1:500-1:1,000
          -
          Product Specifications

          Species Reactivity

          Bovine, Human, Mouse, Pig, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          KLH conjugated synthetic peptide derived from human STAT5.

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Purification

          Protein A

          Storage buffer

          0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

          Contains

          0.02% ProClin 300

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Target Information

          The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of, many cell ligands, such as IL-2, IL-3, IL-7, GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/ BCL-X(L), which suggests the antiapoptotic function of this gene in cells.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: Mammary gland factor; mammary gland factor STAT5A; mammary gland factor STAT5B; signal transducer and activator of transcription 5; Signal transducer and activator of transcription 5A; Signal transducer and activator of transcription 5B; STA5B; STAT; STAT5A, Mammary Gland Factor; transcription factor STAT5B

          View more View less

          Gene Aliases: AA959963; BOS_19069; BOS_19070; MGF; Mpf; STAT5; STAT5A; STAT5A/MGF; STAT5B; STATA5

          View more View less

          UniProt ID: (Human) P42229, (Pig) Q9TUZ1, (Bovine) Q95115, (Bovine) Q9TUM3, (Human) P51692, (Pig) Q9TUZ0, (Rat) Q62771, (Mouse) P42230, (Rat) P52632, (Mouse) P42232

          View more View less

          Entrez Gene ID: (Human) 6776, (Pig) 397550, (Bovine) 282375, (Bovine) 282376, (Human) 6777, (Pig) 397340, (Rat) 24918, (Mouse) 20850, (Rat) 25126, (Mouse) 20851

          View more View less

          Function(s)
          DNA binding transcription factor activity, sequence-specific DNA binding protein tyrosine kinase activity signal transducer activity protein binding calcium ion binding RNA polymerase II core promoter sequence-specific DNA binding glucocorticoid receptor binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding chromatin binding protein phosphatase binding protein dimerization activity double-stranded DNA binding sequence-specific DNA binding
          Process(es)
          allantoin metabolic process luteinization natural killer cell differentiation citrate metabolic process 2-oxoglutarate metabolic process succinate metabolic process oxaloacetate metabolic process transcription, DNA-templated isoleucine metabolic process valine metabolic process creatine metabolic process fatty acid metabolic process JAK-STAT cascade female pregnancy lactation positive regulation of cell proliferation regulation of steroid metabolic process cytokine-mediated signaling pathway taurine metabolic process lipid storage regulation of cell adhesion regulation of epithelial cell differentiation response to estradiol positive regulation of natural killer cell proliferation positive regulation of natural killer cell differentiation T cell differentiation in thymus prolactin signaling pathway positive regulation of multicellular organism growth positive regulation of activated T cell proliferation progesterone metabolic process T cell homeostasis negative regulation of apoptotic process positive regulation of interleukin-2 biosynthetic process positive regulation of B cell differentiation positive regulation of gamma-delta T cell differentiation negative regulation of erythrocyte differentiation positive regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter positive regulation of natural killer cell mediated cytotoxicity creatinine metabolic process development of secondary female sexual characteristics development of secondary male sexual characteristics Peyer's patch development positive regulation of inflammatory response JAK-STAT cascade involved in growth hormone signaling pathway response to interleukin-2 response to interleukin-4 response to interleukin-15 regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter signal transduction peptidyl-tyrosine phosphorylation mammary gland development response to nutrient levels negative regulation of mast cell apoptotic process regulation of multicellular organism growth response to peptide hormone response to ethanol positive regulation of lymphocyte differentiation multicellular organismal reproductive process mammary gland involution positive regulation of mast cell differentiation prostate gland epithelium morphogenesis epithelial cell differentiation involved in prostate gland development mammary gland epithelium development positive regulation of mast cell proliferation cellular response to granulocyte macrophage colony-stimulating factor stimulus response to hypoxia liver development acute-phase response sex differentiation response to lipopolysaccharide cellular response to hormone stimulus positive regulation of smooth muscle cell proliferation positive regulation of cellular component movement cellular response to growth factor stimulus cellular response to epidermal growth factor stimulus positive regulation of endothelial cell proliferation positive regulation of blood vessel endothelial cell migration mast cell migration positive regulation of erythrocyte differentiation
          It has to be done as per old AB suggested Products section.
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