Invitrogen

STAT5 alpha/beta Recombinant Rabbit Monoclonal Antibody (JJ08-78)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-32452

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

Flow Cytometry (Flow)

1:50-1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

JJ08-78

Immunogen

Recombinant protein within mouse Stat5b aa 585-773
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 40% Glycerol, 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2809729

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of, many cell ligands, such as IL-2, IL-3, IL-7, GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/ BCL-X(L), which suggests the antiapoptotic function of this gene in cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Mammary gland factor; mammary gland factor STAT5A; mammary gland factor STAT5B; signal transducer and activator of transcription 5; Signal transducer and activator of transcription 5A; Signal transducer and activator of transcription 5B; STA5B; STAT; transcription factor STAT5B

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Gene Aliases: AA959963; MGF; Mpf; STAT5; STAT5A; STAT5B

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UniProt ID: (Human) P42229, (Human) P51692, (Rat) Q62771, (Mouse) P42230, (Rat) P52632, (Mouse) P42232

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Entrez Gene ID: (Human) 6776, (Human) 6777, (Rat) 24918, (Mouse) 20850, (Rat) 25126, (Mouse) 20851

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Function(s)
DNA binding transcription factor activity, sequence-specific DNA binding protein tyrosine kinase activity signal transducer activity protein binding RNA polymerase II core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding chromatin binding protein phosphatase binding glucocorticoid receptor binding protein dimerization activity double-stranded DNA binding sequence-specific DNA binding
Process(es)
allantoin metabolic process luteinization natural killer cell differentiation citrate metabolic process 2-oxoglutarate metabolic process succinate metabolic process oxaloacetate metabolic process transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter isoleucine metabolic process valine metabolic process creatine metabolic process fatty acid metabolic process signal transduction JAK-STAT cascade female pregnancy lactation positive regulation of cell proliferation peptidyl-tyrosine phosphorylation regulation of steroid metabolic process cytokine-mediated signaling pathway taurine metabolic process lipid storage regulation of cell adhesion regulation of epithelial cell differentiation mammary gland development response to nutrient levels positive regulation of natural killer cell differentiation negative regulation of mast cell apoptotic process T cell differentiation in thymus prolactin signaling pathway regulation of multicellular organism growth positive regulation of multicellular organism growth positive regulation of activated T cell proliferation T cell homeostasis negative regulation of apoptotic process response to peptide hormone positive regulation of interleukin-2 biosynthetic process response to ethanol positive regulation of B cell differentiation positive regulation of gamma-delta T cell differentiation positive regulation of lymphocyte differentiation negative regulation of erythrocyte differentiation positive regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter positive regulation of natural killer cell mediated cytotoxicity creatinine metabolic process development of secondary female sexual characteristics development of secondary male sexual characteristics Peyer's patch development multicellular organismal reproductive process positive regulation of inflammatory response mammary gland involution positive regulation of mast cell differentiation JAK-STAT cascade involved in growth hormone signaling pathway prostate gland epithelium morphogenesis epithelial cell differentiation involved in prostate gland development mammary gland epithelium development positive regulation of mast cell proliferation cellular response to granulocyte macrophage colony-stimulating factor stimulus response to hypoxia liver development acute-phase response sex differentiation response to estradiol response to lipopolysaccharide positive regulation of natural killer cell proliferation cellular response to hormone stimulus progesterone metabolic process positive regulation of smooth muscle cell proliferation positive regulation of cellular component movement response to interleukin-2 response to interleukin-4 response to interleukin-15 cellular response to growth factor stimulus cellular response to epidermal growth factor stimulus positive regulation of endothelial cell proliferation positive regulation of blood vessel endothelial cell migration mast cell migration positive regulation of erythrocyte differentiation
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