Proteintech

STAU1 Polyclonal Antibody

STAU1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 6

STAU1 Antibody (14225-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed HeLa cells using 14225-1-AP (STAU1 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

STAU1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

14225-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 9 publications 9 publications

Immunocytochemistry (ICC/IF)

1:50-1:500

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

RNA Immunoprecipitation (RIP)

View 3 publications 3 publications

Miscellaneous PubMed (MISC)

View 2 publications 2 publications

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

STAU1 Fusion Protein Ag5464 (227-577 aa encoded by BC050432)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: GEGEGKSKK ISKKNAAIAV LEELKKLPPL PAVERVKPRI KKKTKPIVKP QTSPEYGQGI NPISRLAQIQ QAKKEKEPEY TLLTERGLPR RREFVMQVKV GNHTAEGTGT NKKVAKRNAA ENMLEILGFK VPQAQPTKPA LKSEEKTPIK KPGDGRKVTF FEPGSGDENG TSNKEDEFRM PYLSHQQLPA GILPMVPEVA QAVGVSQGHH TKDFTRAAPN PAKATVTAMI ARELLYGGTS PTAETILKNN ISSGHVPHGP LTRPSEQLDY LSRVQGFQVE YKDFPKNNKN EFVSLINCSS QPPLISHGIG KDVESCHDMA ALNILKLLSE LDQQSTEMPR TGNGPMSVCG RC (227-577 aa encoded by BC050432)

Target Information

STAU1 is a member of a family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human STAU1 also contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. STAU1 has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER. STAU1 is also known to interact with influenza ribonucleoproteins NS1, NP, and PA and is required for efficient viral replication.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

LncCCLM inhibits lymphatic metastasis of cervical cancer by promoting STAU1-mediated IGF-1 mRNA degradation.

Cancer letters

Chen C,Shen N,Chen Y,Jiang P,Sun W,Wang Q,Wang Z,Jiang Y,Cheng W,Fu S,Wang S

Sun Oct 10 00:00:00 UTC 2021

LncCCLM inhibits lymphatic metastasis of cervical cancer by promoting STAU1-mediated IGF-1 mRNA degradation.

Cancer letters

Chen C,Shen N,Chen Y,Jiang P,Sun W,Wang Q,Wang Z,Jiang Y,Cheng W,Fu S,Wang S

Sun Oct 10 00:00:00 UTC 2021

Long noncoding RNA TINCR is a novel regulator of human bronchial epithelial cell differentiation state.

Physiological reports

Omote N,Sakamoto K,Li Q,Schupp JC,Adams T,Ahangari F,Chioccioli M,DeIuliis G,Hashimoto N,Hasegawa Y,Kaminski N

Mon Feb 01 00:00:00 UTC 2021

NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis.

Cell metabolism

Park MK,Zhang L,Min KW,Cho JH,Yeh CC,Moon H,Hormaechea-Agulla D,Mun H,Ko S,Lee JW,Jathar S,Smith AS,Yao Y,Giang NT,Vu HH,Yan VC,Bridges MC,Kourtidis A,Muller F,Chang JH,Song SJ,Nakagawa S,Hirose T,Yoon JH,Song MS

Tue Dec 07 00:00:00 UTC 2021

RBFOX1 Regulates the Permeability of the Blood-Tumor Barrier via the LINC00673/MAFF Pathway.

Molecular therapy oncolytics

Shen S,Yang C,Liu X,Zheng J,Liu Y,Liu L,Ma J,Ma T,An P,Lin Y,Cai H,Wang D,Li Z,Zhao L,Xue Y

Fri Jun 26 00:00:00 UTC 2020

PABPC1-induced stabilization of BDNF-AS inhibits malignant progression of glioblastoma cells through STAU1-mediated decay.

Cell death & disease

Su R,Ma J,Zheng J,Liu X,Liu Y,Ruan X,Shen S,Yang C,Wang D,Cai H,Li Z,Xue Y

Mon Feb 03 00:00:00 UTC 2020

Staufen1 reads out structure and sequence features in ARF1 dsRNA for target recognition.

Nucleic acids research

Yadav DK,Zigáčková D,Zlobina M,Klumpler T,Beaumont C,Kubíčková M,Vaňáčová Š,Lukavsky PJ

Fri Feb 28 00:00:00 UTC 2020

STAU1 binds to IBDV genomic double-stranded RNA and promotes viral replication via attenuation of MDA5-dependent β interferon induction.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Ye C,Yu Z,Xiong Y,Wang Y,Ruan Y,Guo Y,Chen M,Luan S,Zhang E,Liu H

Tue Jan 01 00:00:00 UTC 2019

STAU1 binds to IBDV genomic double-stranded RNA and promotes viral replication via attenuation of MDA5-dependent β interferon induction.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Ye C,Yu Z,Xiong Y,Wang Y,Ruan Y,Guo Y,Chen M,Luan S,Zhang E,Liu H

Tue Jan 01 00:00:00 UTC 2019

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

Molecular cell

Lee SH,Mayr C

Thu May 16 00:00:00 UTC 2019

Comprehensive analysis of the BC200 ribonucleoprotein reveals a reciprocal regulatory function with CSDE1/UNR.

Nucleic acids research

Booy EP,McRae EK,Ezzati P,Choi T,Gussakovsky D,McKenna SA

Fri Nov 30 00:00:00 UTC 2018

Comprehensive analysis of the BC200 ribonucleoprotein reveals a reciprocal regulatory function with CSDE1/UNR.

Nucleic acids research

Booy EP,McRae EK,Ezzati P,Choi T,Gussakovsky D,McKenna SA

Fri Nov 30 00:00:00 UTC 2018

Lipopolysaccharide enhances ADAR2 which drives Hirschsprung's disease by impairing miR-142-3p biogenesis.

Journal of cellular and molecular medicine

Peng L,Zhang H,Su Y,Shen Q,Du C,Xie H,Li H,Yan J,Shen Z,Jiang W,Xia Y,Xu X,Tang W

Sat Sep 01 00:00:00 UTC 2018

Lipopolysaccharide enhances ADAR2 which drives Hirschsprung's disease by impairing miR-142-3p biogenesis.

Journal of cellular and molecular medicine

Peng L,Zhang H,Su Y,Shen Q,Du C,Xie H,Li H,Yan J,Shen Z,Jiang W,Xia Y,Xu X,Tang W

Sat Sep 01 00:00:00 UTC 2018

Vinca alkaloid drugs promote stress-induced translational repression and stress granule formation.

Oncotarget

Szaflarski W,Fay MM,Kedersha N,Zabel M,Anderson P,Ivanov P

Tue May 24 00:00:00 UTC 2016

Vinca alkaloid drugs promote stress-induced translational repression and stress granule formation.

Oncotarget

Szaflarski W,Fay MM,Kedersha N,Zabel M,Anderson P,Ivanov P

Tue May 24 00:00:00 UTC 2016

SNHG5 promotes colorectal cancer cell survival by counteracting STAU1-mediated mRNA destabilization.

Nature communications

Damas ND,Marcatti M,Côme C,Christensen LL,Nielsen MM,Baumgartner R,Gylling HM,Maglieri G,Rundsten CF,Seemann SE,Rapin N,Thézenas S,Vang S,Ørntoft T,Andersen CL,Pedersen JS,Lund AH

Thu Dec 22 00:00:00 UTC 2016

SNHG5 promotes colorectal cancer cell survival by counteracting STAU1-mediated mRNA destabilization.

Nature communications

Damas ND,Marcatti M,Côme C,Christensen LL,Nielsen MM,Baumgartner R,Gylling HM,Maglieri G,Rundsten CF,Seemann SE,Rapin N,Thézenas S,Vang S,Ørntoft T,Andersen CL,Pedersen JS,Lund AH

Thu Dec 22 00:00:00 UTC 2016

hiCLIP reveals the in vivo atlas of mRNA secondary structures recognized by Staufen 1.

Nature

Sugimoto Y,Vigilante A,Darbo E,Zirra A,Militti C,D'Ambrogio A,Luscombe NM,Ule J

Thu Mar 26 00:00:00 UTC 2015

hiCLIP reveals the in vivo atlas of mRNA secondary structures recognized by Staufen 1.

Nature

Sugimoto Y,Vigilante A,Darbo E,Zirra A,Militti C,D'Ambrogio A,Luscombe NM,Ule J

Thu Mar 26 00:00:00 UTC 2015

Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations.

Neuron

Alami NH,Smith RB,Carrasco MA,Williams LA,Winborn CS,Han SSW,Kiskinis E,Winborn B,Freibaum BD,Kanagaraj A,Clare AJ,Badders NM,Bilican B,Chaum E,Chandran S,Shaw CE,Eggan KC,Maniatis T,Taylor JP

Wed Feb 05 00:00:00 UTC 2014

Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations.

Neuron

Alami NH,Smith RB,Carrasco MA,Williams LA,Winborn CS,Han SSW,Kiskinis E,Winborn B,Freibaum BD,Kanagaraj A,Clare AJ,Badders NM,Bilican B,Chaum E,Chandran S,Shaw CE,Eggan KC,Maniatis T,Taylor JP

Wed Feb 05 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: Double-stranded RNA-binding protein Staufen homolog 1; protein phosphatase 1, regulatory subunit 150; RP3-470L14.2; staufen RNA binding protein homolog 1; staufen, RNA binding protein, homolog 1

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Gene Aliases: 5830401L18Rik; AW549911; C85792; PPP1R150; STAU; STAU1

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UniProt ID: (Human) O95793, (Mouse) Q9Z108

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Entrez Gene ID: (Human) 6780, (Rat) 84496, (Mouse) 20853

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Function(s)

double-stranded RNA binding protein binding protein phosphatase 1 binding poly(A) RNA binding RNA binding

Process(es)

intracellular mRNA localization positive regulation of viral genome replication positive regulation by virus of viral protein levels in host cell cellular response to oxidative stress positive regulation of long-term synaptic potentiation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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STAU1 Polyclonal Antibody

STAU1 Antibody (14225-1-AP) in ICC/IF

Product Details

14225-1-AP

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

RNA Immunoprecipitation (RIP)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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