Proteintech

STEAP2 Polyclonal Antibody

STEAP2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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STEAP2 Antibody (20201-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human heart using 20201-1-AP (STEAP2-Specific antibody) at dilution of 1:100 (under 40x lens).

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Product Details

20201-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 3 publications 3 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.28 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

The antibody is specific to STEAP2.

Target Information

The six-transmembrane epithelial antigen of prostate 2 (STEAP2) is a member of a family of metalloreductases identified as cell-surface antigens in prostate tissue. Similar to two other members of the STEAP family (STEAP 3 and STEAP4), STEAP2 promotes both iron and copper reduction. STEAP2 expression in transfected cells also correlated with iron or copper uptake, suggesting that the STEAP family of proteins may function to stimulate iron and copper uptake. STEAP2 is widely expressed in many tissues in the plasma membrane, but is most highly expressed in prostate. At least three isoforms of STEAP2 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

STEAP2 promotes osteosarcoma progression by inducing epithelial-mesenchymal transition via the PI3K/AKT/mTOR signaling pathway and is regulated by EFEMP2.

Cancer biology & therapy

Zhang D,Liu H,Wang W,Xu G,Yin C,Wang S

Sat Dec 31 00:00:00 UTC 2022

METTL3-mediated m6A modification of STEAP2 mRNA inhibits papillary thyroid cancer progress by blocking the Hedgehog signaling pathway and epithelial-to-mesenchymal transition.

Cell death & disease

Zhu Y,Peng X,Zhou Q,Tan L,Zhang C,Lin S,Long M

Mon Apr 18 00:00:00 UTC 2022

METTL3-mediated m6A modification of STEAP2 mRNA inhibits papillary thyroid cancer progress by blocking the Hedgehog signaling pathway and epithelial-to-mesenchymal transition.

Cell death & disease

Zhu Y,Peng X,Zhou Q,Tan L,Zhang C,Lin S,Long M

Mon Apr 18 00:00:00 UTC 2022

Membrane cholesterol modulates STEAP2 conformation during dynamic intracellular trafficking processes leading to broad subcellular distribution.

Experimental cell research

Hasegawa H,Li C,Alba BM,Penny DM,Xia Z,Dayao MR,Li P,Zhang J,Zhou J,Lim D,Murawsky CM,Lim AC

Sat Sep 15 00:00:00 UTC 2018

Membrane cholesterol modulates STEAP2 conformation during dynamic intracellular trafficking processes leading to broad subcellular distribution.

Experimental cell research

Hasegawa H,Li C,Alba BM,Penny DM,Xia Z,Dayao MR,Li P,Zhang J,Zhou J,Lim D,Murawsky CM,Lim AC

Sat Sep 15 00:00:00 UTC 2018

Bioinformatics

Protein Aliases: Metalloreductase STEAP2; prostate cancer associated protein 1; Prostate cancer-associated protein 1; Protein up-regulated in metastatic prostate cancer; protein upregulated in metastatic prostate cancer; PUMPCn; six transmembrane epithelial antigen of prostate 2; six transmembrane epithelial antigen of the prostate 2; Six-transmembrane epithelial antigen of prostate 2; SixTransMembrane Protein of Prostate 1; STEAP family member 2, metalloreductase

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Gene Aliases: 4921538B17Rik; AI930049; AW045895; IPCA-1; IPCA1; PCANAP1; PUMPCn; STAMP1; STEAP2; STMP; UNQ6507/PRO23203

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UniProt ID: (Human) Q8NFT2, (Mouse) Q8BWB6

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Entrez Gene ID: (Human) 261729, (Mouse) 74051

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Function(s)

transporter activity cupric reductase activity metal ion binding ferric-chelate reductase (NADPH) activity oxidoreductase activity

Process(es)

transport ion transport Golgi to plasma membrane transport endocytosis response to hormone copper ion import regulated exocytosis iron ion homeostasis oxidation-reduction process ferric iron import into cell

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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STEAP2 Polyclonal Antibody

STEAP2 Antibody (20201-1-AP) in IHC (P)

Product Details

20201-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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