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Invitrogen
STEAP3 Polyclonal Antibody
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STEAP3 Antibody (PA5-87478) in WB
Western blot analysis of STEAP3 in extracts of Mouse heart. Samples were incubated with STEAP3 Polyclonal antibody (Product # PA5-87478) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 60s.
Product Details
PA5-87478
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human STEAP3 (NP_0607042)
Conjugate
Form
Liquid
Concentration
3.05 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2804184
Product Specific Information
Immunogen sequence: MPEEMDKPLI SLHLVDSDSS LAKVPDEAPK VGILGSGDFA RSLATRLVGS GFKVVVGSRN PKRTARLFPS AAQVTFQEEA VSSPEVIFVA VFREHYSSLC SLSDQLAGKI LVDVSNPTEQ EHLQHRESNA EYLASLFPTC TVVKAFNVIS AWTLQAGPRD GNRQVPICGD QPEAKRAVSE; Positive Samples: Mouse heart; Cellular Location: Endosome membrane, Multi-pass membrane protein
Target Information
The six-transmembrane epithelial antigen of prostate 3 (STEAP3) is a member of a family of metalloreductases identified as cell-surface antigens in prostate tissue. Similar to two other members of the STEAP family (STEAP 2 and STEAP4), STEAP3 promotes both iron and copper reduction. STEAP3 is highly expressed in hematopoietic tissues and colocalizes with the transferrin endosome. Overexpression of STEAP3 stimulates iron reduction; mice lacking STEAP3 are deficient in erythroid ferrireductase activity, suggesting that STEAP3 is an endosomal ferrireductase required for transferrin-dependent iron uptake in erythroid cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dudlin 2; dudulin 2; Dudulin-2; Metalloreductase STEAP3; Protein nm1054; Six-transmembrane epithelial antigen of prostate 3; Tumor suppressor-activated pathway protein 6
Gene Aliases: 1010001D01Rik; pHyde; Steap3; Tsap6
UniProt ID: (Mouse) Q8CI59
Entrez Gene ID: (Mouse) 68428
transport
ion transport
iron ion transport
apoptotic process
cell cycle
protein secretion
copper ion import
positive regulation of apoptotic process
iron ion homeostasis
oxidation-reduction process
ferric iron import into cell
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
exosomal secretion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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