Proteintech

STEAP4 Polyclonal Antibody

STEAP4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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STEAP4 Antibody (11944-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human prostate cancer tissue slide using 11944-1-AP (STEAP4 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

STEAP4 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

11944-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 25 publications 25 publications

Immunohistochemistry (IHC)

View 15 publications 15 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

STEAP4 Fusion Protein Ag2545 (1-283 aa encoded by BC020600)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MEKTCIDAL PLTMNSSEKQ ETVCIFGTGD FGRSLGLKML QCGYSVVFGS RNPQKTTLLP SGAEVLSYSE AAKKSGIIII AIHREHYDFL TELTEVLNGK ILVDISNNLK INQYPESNAE YLAHLVPGAH VVKAFNTISA WALQSGALDA SRQAILKKEN PFSTSSAWLS DSYVALGILG FFLFVLLGIT SLPSVSNAVN WREFRFVQSK LGYLTLILCT AHTLVYGGKR FLSPSNLRWY LPAAYVLGLI IPCTVLVIKF VLIMPCVDNT LTRIRQGWER NSKH (1-283 aa encoded by BC020600)

Target Information

The six-transmembrane epithelial antigen of prostate 4 (STEAP4) is a member of a family of metalloreductases identified as cell-surface antigens in prostate tissue. Similar to two other members of the STEAP family (STEAP 2 and STEAP3), STEAP4 promotes both iron and copper reduction. STEAP4 is highly expressed in placenta, lung, heart and prostate tissues, and overexpressed in prostate cancer cells compared to normal prostate cells. Overexpression of STEAP4 in prostate cells significantly increases cell growth and colony formation, suggesting STEAP4 may have a role in cell proliferation and prostate cancer progression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Overexpressing six-transmembrane protein of prostate 2 (STAMP2) alleviates sepsis-induced acute lung injury probably by hindering M1 macrophage polarization via the NF-κB pathway.

Folia histochemica et cytobiologica

Ji L,Shi X,Wang G,Wu H,Hu Z

Thu Mar 30 00:00:00 UTC 2023

Overexpressing six-transmembrane protein of prostate 2 (STAMP2) alleviates sepsis-induced acute lung injury probably by hindering M1 macrophage polarization via the NF-κB pathway.

Folia histochemica et cytobiologica

Ji L,Shi X,Wang G,Wu H,Hu Z

Thu Mar 30 00:00:00 UTC 2023

STEAP4 promoter methylation correlates with tumorigenesis of hepatocellular carcinoma.

Pathology, research and practice

Tang Y,Wang Y,Xu X,Sun H,Tang W

Sun May 01 00:00:00 UTC 2022

sSTEAP4 regulates cellular homeostasis and improves high-fat-diet-caused oxidative stress in hepatocytes.

Life sciences

Zhu L,Li B,Chen D,Chen N,Xu L,Li Q,Chen X

Sun May 01 00:00:00 UTC 2022

STAMP2 Attenuates Cardiac Dysfunction and Insulin Resistance in Diabetic Cardiomyopathy via NMRAL1-Mediated NF-κB Inhibition in Type 2 Diabetic Rats.

Diabetes, metabolic syndrome and obesity : targets and therapy

Gao Z,Ti Y,Lu B,Song FQ,Zhang L,Hu BA,Xie JY,Zhang W,Han L,Zhong M

Tue Nov 01 00:00:00 UTC 2022

METTL3-mediated m6A modification of STEAP2 mRNA inhibits papillary thyroid cancer progress by blocking the Hedgehog signaling pathway and epithelial-to-mesenchymal transition.

Cell death & disease

Zhu Y,Peng X,Zhou Q,Tan L,Zhang C,Lin S,Long M

Mon Apr 18 00:00:00 UTC 2022

Potential of six-transmembrane epithelial antigen of the prostate 4 as a prognostic marker for colorectal cancer.

World journal of gastrointestinal oncology

Fang ZX,Li CL,Chen WJ,Wu HT,Liu J

Thu Sep 15 00:00:00 UTC 2022

Hepatic STAMP2 alleviates polychlorinated biphenyl-induced steatosis and hepatic iron overload in NAFLD models.

Environmental toxicology

Kim HY,Park CH,Park JB,Ko K,Lee MH,Chung J,Yoo YH

Thu Sep 01 00:00:00 UTC 2022

Hepatic STAMP2 alleviates polychlorinated biphenyl-induced steatosis and hepatic iron overload in NAFLD models.

Environmental toxicology

Kim HY,Park CH,Park JB,Ko K,Lee MH,Chung J,Yoo YH

Thu Sep 01 00:00:00 UTC 2022

Hepatic STAMP2 alleviates polychlorinated biphenyl-induced steatosis and hepatic iron overload in NAFLD models.

Environmental toxicology

Kim HY,Park CH,Park JB,Ko K,Lee MH,Chung J,Yoo YH

Thu Sep 01 00:00:00 UTC 2022

Hepatic STAMP2 alleviates polychlorinated biphenyl-induced steatosis and hepatic iron overload in NAFLD models.

Environmental toxicology

Kim HY,Park CH,Park JB,Ko K,Lee MH,Chung J,Yoo YH

Thu Sep 01 00:00:00 UTC 2022

The expression of STEAP4 in peripheral blood predicts the outcome of septic patients.

Annals of translational medicine

Jiang H,Dong Y,Yan D,Wu Y,Wang Y,Ren Y,Mao G,Liang G,Liu W,Zhou Y,Huang Z,Qi L

Fri Oct 01 00:00:00 UTC 2021

Discovery and Pharmacological Evaluation of STEAP4 as a Novel Target for HER2 Overexpressing Breast Cancer.

Frontiers in oncology

Orfanou IM,Argyros O,Papapetropoulos A,Tseleni-Balafouta S,Vougas K,Tamvakopoulos C

Tue Apr 13 00:00:00 UTC 2021

Discovery and Pharmacological Evaluation of STEAP4 as a Novel Target for HER2 Overexpressing Breast Cancer.

Frontiers in oncology

Orfanou IM,Argyros O,Papapetropoulos A,Tseleni-Balafouta S,Vougas K,Tamvakopoulos C

Tue Apr 13 00:00:00 UTC 2021

Discovery and Pharmacological Evaluation of STEAP4 as a Novel Target for HER2 Overexpressing Breast Cancer.

Frontiers in oncology

Orfanou IM,Argyros O,Papapetropoulos A,Tseleni-Balafouta S,Vougas K,Tamvakopoulos C

Tue Apr 13 00:00:00 UTC 2021

Overexpressing STAMP2 attenuates diabetic renal injuries via upregulating autophagy in diabetic rats.

Biochemical and biophysical research communications

Song FQ,Song M,Ma WX,Gao Z,Ti Y,Zhang X,Hu BA,Zhong M,Zhang W,Yu Y

Fri Nov 19 00:00:00 UTC 2021

Hepatic STAMP2 mediates recombinant FGF21-induced improvement of hepatic iron overload in nonalcoholic fatty liver disease.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Kim HY,Kwon WY,Park JB,Lee MH,Oh YJ,Suh S,Baek YH,Jeong JS,Yoo YH

Tue Sep 01 00:00:00 UTC 2020

Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis.

Nature communications

Liao Y,Zhao J,Bulek K,Tang F,Chen X,Cai G,Jia S,Fox PL,Huang E,Pizarro TT,Kalady MF,Jackson MW,Bao S,Sen GC,Stark GR,Chang CJ,Li X

Fri Feb 14 00:00:00 UTC 2020

Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis.

Nature communications

Liao Y,Zhao J,Bulek K,Tang F,Chen X,Cai G,Jia S,Fox PL,Huang E,Pizarro TT,Kalady MF,Jackson MW,Bao S,Sen GC,Stark GR,Chang CJ,Li X

Fri Feb 14 00:00:00 UTC 2020

Hepatic Steatosis Alleviated in Diabetic Mice upon Dietary Exposure to Fibroin via Transgenic Rice: Potential STAMP2 Involvement in Hepatocytes.

Development & reproduction

Park JE,Jeong YJ,Kim HY,Yoo YH,Lee KS,Yang WT,Kim DH,Kim JM

Tue Sep 01 00:00:00 UTC 2020

Hepatic Steatosis Alleviated in Diabetic Mice upon Dietary Exposure to Fibroin via Transgenic Rice: Potential STAMP2 Involvement in Hepatocytes.

Development & reproduction

Park JE,Jeong YJ,Kim HY,Yoo YH,Lee KS,Yang WT,Kim DH,Kim JM

Tue Sep 01 00:00:00 UTC 2020

The six-transmembrane protein Stamp2 ameliorates pulmonary vascular remodeling and pulmonary hypertension in mice.

Basic research in cardiology