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Invitrogen
STIM1 Recombinant Rabbit Monoclonal Antibody (10N9E7)
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STIM1 Antibody (MA5-51443) in IHC (P)
Immunohistochemistry analysis of STIM1 in paraffin-embedded human placenta. Samples were incubated with STIM1 Recombinant monoclonal antibody (Product # MA5-51443) using a dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Product Details
MA5-51443
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
10N9E7
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 530-685 of human STIM1 (NP_003147.2).
Conjugate
Form
Liquid
Concentration
0.203 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3093019
Product Specific Information
Immunogen sequence: RQRVAPKPPQ MSRAADEALN AMTSNGSHRL IEGVHPGSLV EKLPDSPALA KKALLALNHG LDKAHSLMEL SPSAPPGGSP HLDSSRSHSP SSPDPDTPSP VGDSRALQAS RNTRIPHLAG KKAVAEEDNG SIGEETDSSP GRKKFPLKIF KKPLKK
Target Information
STIM1 (stromal interacting molecule; also known as GOK) acts as a sensor of calcium depletion within the endoplasmic reticulum and transduces the signal to Orai1, the presumptive CRAC channel at the plasma membrane. Following decrease of luminal calcium concentration, STIM1 oligomerizes and induces Orai1 to enable entry of extracellular calcium into the cytoplasm. However, the precise mechanism of STIM1-Orai1 interaction has not been elucidated yet. Many questions also remain to be solved around STIM1 functional distribution. It turns out that STIM1 associates with growing ends of microtubules and is involved in endoplasmic reticulum tubule extension.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: STIM1L; Stromal interaction molecule 1
Gene Aliases: D11S4896E; GOK; IMD10; STIM1; STRMK; TAM; TAM1
UniProt ID: (Human) Q13586
Entrez Gene ID: (Human) 6786
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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