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Product Details
BS-6782R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human STK26, amino acids 241-350.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
MST4 is member of the Ste20-like kinase family of serine/threonine kinases and is overexpressed during prostate cancer development. The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Mammalian STE20-like protein kinase 4; mammalian sterile 20-like 4; MST-4; MST3 and SOK1-related kinase; mst4; OTTHUMP00000215132; OTTHUMP00000215134; RP6-213H19.1; serine/threonine protein kinase MST4; Serine/threonine-protein kinase 26; Serine/threonine-protein kinase MASK; Serine/threonine-protein kinase MST4; STE20-like kinase 4; STE20-like kinase MST4
Gene Aliases: 2610018G03Rik; MASK; MST4; RGD1563568; STK26
UniProt ID: (Human) Q9P289, (Mouse) Q99JT2
Entrez Gene ID: (Human) 51765, (Rat) 317589, (Mouse) 70415
magnesium ion binding
protein kinase activity
receptor signaling protein serine/threonine kinase activity
protein binding
ATP binding
identical protein binding
protein homodimerization activity
nucleotide binding
protein serine/threonine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
metal ion binding
mitotic cell cycle
protein phosphorylation
cellular component disassembly involved in execution phase of apoptosis
signal transduction by protein phosphorylation
microvillus assembly
response to hydrogen peroxide
regulation of apoptotic process
regulation of cell differentiation
protein autophosphorylation
regulation of hydrogen peroxide-induced cell death
apoptotic process
intracellular signal transduction
regulation of mitotic cell cycle
phosphorylation
stress-activated protein kinase signaling cascade
activation of protein kinase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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