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Invitrogen
STK39 Recombinant Rabbit Monoclonal Antibody (0D9L5)
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Product Details
MA5-38038
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
0D9L5
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 401-545 of human STK39 (Q9UEW8)
Conjugate
Form
Liquid
Concentration
0.54 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2897956
Product Specific Information
Positive Samples: Jurkat, SH-SY5Y, Rat testis, Mouse testis
Immunogen sequence: SQEKSRRVKE ENPEIAVSAS TIPEQIQSLS VHDSQGPPNA NEDYREASSC AVNLVLRLRN SRKELNDIRF EFTPGRDTAD GVSQELFSAG LVDGHDVVIV AANLQKIVDD PKALKTLTFK LASGCDGSEI PDEVKLIGFA QLSVS
Target Information
STK39 (STLK3) is involved in the cellular stress response pathway. STK39 is activated in response to hypotonic stress leading to phosphorylation of several cation-chloride-coupled co-transporters. STK39 activates the p38 MAP kinase pathway and its interaction with p38 decreases during cellular stress. STK39 acts as an intermediate in the response to cellular stress. STK39 is also an independent risk factor for hypertension in men and its intragenic SNPs can interact and function in the control of blood pressure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DCHT; DKFZp686K05124; kidney-specific SPAK; Pancreatic serine/threonine-protein kinase; proline-alanine-rich STE20-related kinase; PS/TK; PSTK1; serine threonine kinase 39 (STE20/SPS1 homolog, yeast); serine/threonine kinase 39, STE20/SPS1 homolog; Serine/threonine-protein kinase 39; small intestine SPAK-like kinase; Ste-20 related kinase; Ste-20-related kinase; Ste20-like protein kinase; STE20/SPS1 homolog; STE20/SPS1-related proline-alanine-rich protein kinase
Gene Aliases: AW227544; AW556857; DCHT; PASK; RF005; Rnl5; SPAK; STK39
UniProt ID: (Human) Q9UEW8, (Mouse) Q9Z1W9, (Rat) O88506
Entrez Gene ID: (Human) 27347, (Mouse) 53416, (Rat) 54348
negative regulation of protein phosphorylation
protein phosphorylation
regulation of mitotic cell cycle
regulation of blood pressure
phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
signal transduction by protein phosphorylation
stress-activated protein kinase signaling cascade
activation of protein kinase activity
intracellular signal transduction
regulation of apoptotic process
positive regulation of potassium ion transport
regulation of inflammatory response
cellular hypotonic response
negative regulation of pancreatic juice secretion
negative regulation of potassium ion transmembrane transporter activity
negative regulation of potassium ion transmembrane transport
regulation of ion homeostasis
negative regulation of rubidium ion transport
negative regulation of rubidium ion transmembrane transporter activity
response to stress
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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