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Proteintech
STMN4 Polyclonal Antibody
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Product Details
12027-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
STMN4 Fusion Protein Ag2657 (1-216 aa encoded by BC011520)
Conjugate
Form
Liquid
Concentration
0.41 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MTLAAYKEK MKELPLVSLF CSCFLADPLN KSSYKYEGWC GRQCRRKDES QRKDSADWRE RRAQADTVDL NWCVISDMEV IELNKCTSGQ SFEVILKPPS FDGVPEFNAS LPRRRDPSLE EIQKKLEAAE ERRKYQEAEL LKHLAEKREH EREVIQKAIE ENNNFIKMAK EKLAQKMESN KENREAHLAA MLERLQEKDK HAEEVRKNKE LKEEASR (1-216 aa encoded by BC011520)
Target Information
RB3 (Stathmin-4), encoded by STMN4 gene, is a neuron-specific homologue of the SCG10/stathmin family proteins, possessing a unique N-terminal membrane-associated domain and the stathmin-like domain at the C terminus, which promotes microtubule (MT) catastrophe and/or tubulin sequestering. Stathmin is a ubiquitous cytosolic phosphoprotein, preferentially expressed in the nervous system, and described as a relay integrating diverse intracellular signaling pathways. RB3 is consistently up-regulated in differentiated neuroblastoma cells, and stable expression of transfected RB3 could induce differentiation, suggesting a role of RB3 during neuroblastoma differentiation. Moreover, increased RB3 is a unique response protein in the stathmin-related proteins following optical nerve axotomy and RB3 may be a critical target for neurodegenerative diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: RB3; Stathmin-4; stathmin-like 4; Stathmin-like protein B3; stathmin-like protein RB3; stathmin-like-protein RB3
Gene Aliases: Lagl; R75359; RB3; STMN4
UniProt ID: (Human) Q9H169, (Rat) P63043, (Mouse) P63042
Entrez Gene ID: (Human) 81551, (Rat) 79423, (Mouse) 56471
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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