Proteintech

STOML2 Polyclonal Antibody

STOML2 Antibody in Immunocytochemistry (ICC/IF)

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STOML2 Antibody (10348-1-AP) in ICC/IF

Immunofluorescent analysis of MCF-7 cells, using STOML2 antibody 10348-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IGG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).

STOML2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

STOML2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

10348-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:6,000

View 36 publications 36 publications

Immunohistochemistry (IHC)

View 22 publications 22 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 4 publications 4 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

STOML2 Fusion Protein Ag0363 (81-356 aa encoded by BC002442)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.21 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: EIVINVPEQ SAVTLDNVTL QIDGVLYLRI MDPYKASYGV EDPEYAVTQL AQTTMRSELG KLSLDKVFRE RESLNASIVD AINQAADCWG IRCLRYEIKD IHVPPRVKES MQMQVEAERR KRATVLESEG TRESAINVAE GKKQAQILAS EAEKAEQINQ AAGEASAVLA KAKAKAEAIR ILAAALTQHN GDAAASLTVA EQYVSAFSKL AKDSNTILLP SNPGDVTSMV AQAMGVYGAL TKAPVPGTPD SLSSGSSRDV QGTDASLDEE LDRVKMS (81-356 aa encoded by BC002442)

Target Information

Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Small heat shock proteins operate as molecular chaperones in the mitochondrial intermembrane space.

Nature cell biology

Adriaenssens E,Asselbergh B,Rivera-Mejías P,Bervoets S,Vendredy L,De Winter V,Spaas K,de Rycke R,van Isterdael G,Impens F,Langer T,Timmerman V

Wed Mar 01 00:00:00 UTC 2023

STOML2 restricts mitophagy and increases chemosensitivity in pancreatic cancer through stabilizing PARL-induced PINK1 degradation.

Cell death & disease

Qin C,Wang Y,Zhao B,Li Z,Li T,Yang X,Zhao Y,Wang W

Sat Mar 11 00:00:00 UTC 2023

Stomatin-like Protein-2 Promotes Aggregation, Colonization and Migration of Endometriotic Cells.

Reproductive sciences (Thousand Oaks, Calif.)

Kumari S,Sankhwar P,Tripathi R,Kawale AK,Gupta S,Jha RK

Thu Jun 01 00:00:00 UTC 2023

Stomatin-like Protein-2 Promotes Aggregation, Colonization and Migration of Endometriotic Cells.

Reproductive sciences (Thousand Oaks, Calif.)

Kumari S,Sankhwar P,Tripathi R,Kawale AK,Gupta S,Jha RK

Thu Jun 01 00:00:00 UTC 2023

Mutant CHCHD10 causes an extensive metabolic rewiring that precedes OXPHOS dysfunction in a murine model of mitochondrial cardiomyopathy.

Cell reports

Sayles NM,Southwell N,McAvoy K,Kim K,Pesini A,Anderson CJ,Quinzii C,Cloonan S,Kawamata H,Manfredi G

Tue Mar 08 00:00:00 UTC 2022

STOML2 interacts with PHB through activating MAPK signaling pathway to promote colorectal Cancer proliferation.

Journal of experimental & clinical cancer research : CR

Ma W,Chen Y,Xiong W,Li W,Xu Z,Wang Y,Wei Z,Mou T,Wu Z,Cheng M,Zou Y,Zhu Y,Zhou W,Liu F,Geng Y

Mon Nov 15 00:00:00 UTC 2021

STOML2 interacts with PHB through activating MAPK signaling pathway to promote colorectal Cancer proliferation.

Journal of experimental & clinical cancer research : CR

Ma W,Chen Y,Xiong W,Li W,Xu Z,Wang Y,Wei Z,Mou T,Wu Z,Cheng M,Zou Y,Zhu Y,Zhou W,Liu F,Geng Y

Mon Nov 15 00:00:00 UTC 2021

STOML2 interacts with PHB through activating MAPK signaling pathway to promote colorectal Cancer proliferation.

Journal of experimental & clinical cancer research : CR

Ma W,Chen Y,Xiong W,Li W,Xu Z,Wang Y,Wei Z,Mou T,Wu Z,Cheng M,Zou Y,Zhu Y,Zhou W,Liu F,Geng Y

Mon Nov 15 00:00:00 UTC 2021

STOML2 interacts with PHB through activating MAPK signaling pathway to promote colorectal Cancer proliferation.

Journal of experimental & clinical cancer research : CR

Ma W,Chen Y,Xiong W,Li W,Xu Z,Wang Y,Wei Z,Mou T,Wu Z,Cheng M,Zou Y,Zhu Y,Zhou W,Liu F,Geng Y

Mon Nov 15 00:00:00 UTC 2021

Effect and mechanism of action of SLP-2 on the apoptosis and autophagy of gastric cancer cells.

Oncology letters

Yang S,Huang Y,Zhang H,Wang F,Shao L,Wang X

Fri Oct 01 00:00:00 UTC 2021

Stomatin‑like protein 2 induces metastasis by regulating the expression of a rate‑limiting enzyme of the hexosamine biosynthetic pathway in pancreatic cancer.

Oncology reports

Chao D,Ariake K,Sato S,Ohtsuka H,Takadate T,Ishida M,Masuda K,Maeda S,Miura T,Mitachi K,Yu XJ,Fujishima F,Mizuma M,Nakagawa K,Morikawa T,Kamei T,Unno M

Tue Jun 01 00:00:00 UTC 2021

Miro1 functions as an inhibitory regulator of MFN at elevated mitochondrial Ca²⁺ levels.

Journal of cellular biochemistry

Fatiga FF,Wang LJ,Hsu T,Capuno JI,Fu CY

Wed Dec 01 00:00:00 UTC 2021

Defining the interactome of the human mitochondrial ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly factors.

eLife

Dennerlein S,Poerschke S,Oeljeklaus S,Wang C,Richter-Dennerlein R,Sattmann J,Bauermeister D,Hanitsch E,Stoldt S,Langer T,Jakobs S,Warscheid B,Rehling P

Fri Dec 31 00:00:00 UTC 2021

Coexisting overexpression of STOML1 and STOML2 proteins may be associated with pathology of oral squamous cell carcinoma.

Oral surgery, oral medicine, oral pathology and oral radiology

Wang D,Qi H,Li A,Deng F,Xu Y,Hu Z,Liu Q,Wang Y

Mon Jun 01 00:00:00 UTC 2020

Stomatin-like Protein 2 Promotes Tumor Cell Survival by Activating the JAK2-STAT3-PIM1 Pathway, Suggesting a Novel Therapy in CRC.

Molecular therapy oncolytics

Liu Q,Li A,Wang L,He W,Zhao L,Wu C,Lu S,Ye X,Zhao H,Shen X,Xiao X,Liu Z

Fri Jun 26 00:00:00 UTC 2020

Stomatin-like Protein 2 Promotes Tumor Cell Survival by Activating the JAK2-STAT3-PIM1 Pathway, Suggesting a Novel Therapy in CRC.

Molecular therapy oncolytics

Liu Q,Li A,Wang L,He W,Zhao L,Wu C,Lu S,Ye X,Zhao H,Shen X,Xiao X,Liu Z

Fri Jun 26 00:00:00 UTC 2020

Stomatin-like protein-2 confers neuroprotection effect in oxygen-glucose deprivation/reoxygenation-injured neurons by regulating AMPK/Nrf2 signalling.

Journal of drug targeting

Wang M,Li C,Shi W

Wed Jul 01 00:00:00 UTC 2020

STOML2 as a novel prognostic biomarker modulates cell proliferation, motility and chemo-sensitivity via IL6-Stat3 pathway in head and neck squamous cell carcinoma.

American journal of translational research

Qu H,Jiang W,Wang Y,Chen P

Thu Oct 01 00:00:00 UTC 2020

STOML2 as a novel prognostic biomarker modulates cell proliferation, motility and chemo-sensitivity via IL6-Stat3 pathway in head and neck squamous cell carcinoma.

American journal of translational research

Qu H,Jiang W,Wang Y,Chen P

Thu Oct 01 00:00:00 UTC 2020

Mitochondrial stress response triggered by defects in protein synthesis quality control.

Life science alliance

Richter U,Ng KY,Suomi F,Marttinen P,Turunen T,Jackson C,Suomalainen A,Vihinen H,Jokitalo E,Nyman TA,Isokallio MA,Stewart JB,Mancini C,Brusco A,Seneca S,Lombès A,Taylor RW,Battersby BJ

Fri Feb 01 00:00:00 UTC 2019

Prohibitin is a positive modulator of mitochondrial function in PC12 cells under oxidative stress.

Journal of neurochemistry

Anderson CJ,Kahl A,Qian L,Stepanova A,Starkov A,Manfredi G,Iadecola C,Zhou P

Wed Aug 01 00:00:00 UTC 2018

Prohibitin is a positive modulator of mitochondrial function in PC12 cells under oxidative stress.

Journal of neurochemistry

Anderson CJ,Kahl A,Qian L,Stepanova A,Starkov A,Manfredi G,Iadecola C,Zhou P

Wed Aug 01 00:00:00 UTC 2018

The diagnostic value of TROP-2, SLP-2 and CD56 expression in papillary thyroid carcinoma.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

Yang X,Hu Y,Shi H,Zhang C,Wang Z,Liu X,Chen H,Zhang L,Cui D

Wed Aug 01 00:00:00 UTC 2018

The diagnostic value of TROP-2, SLP-2 and CD56 expression in papillary thyroid carcinoma.

Yang X,Hu Y,Shi H,Zhang C,Wang Z,Liu X,Chen H,Zhang L,Cui D

Wed Aug 01 00:00:00 UTC 2018

A Positive Feedback Loop of SLP2 Activates MAPK Signaling Pathway to Promote Gastric Cancer Progression.

Theranostics