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Product Details
H00092335-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
STRADA (NP_699166.2, 1 a.a. approximately 348 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MSFLTNDASS ESIASFSKQE VMSSFLPEGG CYELLTVIGK GFEDLMTVNL ARYKPTGEYV TVRRINLEAC SNEMVTFLQG ELHVSKLFNH PNIVPYRATF IADNELWVVT SFMAYGSAKD LICTHFMDGM NELAIAYILQ GVLKALDYIH HMGYVHRSVK ASHILISVDG KVYLSGLRSN LSMISHGQRQ RVVHDFPKYS VKVLPWLSPE VLQQNLQGYD AKSDIYSVGI TACELANGHV PFKDMPATQM LLEKLNGTVP CLLDTSTIPA EELTMSPSRS VANSGLSDSL TTSTPRPSNG DSPSHPYHRT FSPHFHHFVE QCLQRNPDAR YPCWPGPGLR ESRGCSGG
Target Information
LYK5; STE20-related Adaptor Protein (STRAD); FLJ90524. Gene Map Locus is 17q23.3 and members of STE-20 like kinase family are known to stimulate MAPK pathways by directly activating MAPKKK. STRAD is a novel pseudokinase member of this family consisting of a STE-20 like kinase domain but lacks several residues that are required for its catalytic activity. It specifically binds LKB1 and plays a key role in regulating tumor suppressor activities of LKB1. It functions as an upstream activator of LKB1 and also directs the sub-cellular localization of LKB1 by anchoring it in the cytoplasm. STRAD-LKB1 interaction results in phosphorylation of STRAD and enhanced autophosphorylation of LKB1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: protein kinase LYK5; Serologically defined breast cancer antigen NY-BR-96; STE20-like pseudokinase; STE20-related adapter protein; STE20-related kinase adapter protein alpha; STRAD alpha
Gene Aliases: LYK5; NY-BR-96; PMSE; Stlk; STRAD; STRADA
UniProt ID: (Human) Q7RTN6
Entrez Gene ID: (Human) 92335
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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