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Proteintech
STRAP Monoclonal Antibody (5E11F3)
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Product Details
66712-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
5E11F3
Immunogen
STRAP Fusion Protein Ag13085 (1-350 aa encoded by BC000162)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAMRQTPLT CSGHTRPVVD LAFSGITPYG YFLISACKDG KPMLRQGDTG DWIGTFLGHK GAVWGATLNK DATKAATAAA DFTAKVWDAV SGDELMTLAH KHIVKTVDFT QDSNYLLTGG QDKLLRIYDL NKPEAEPKEI SGHTSGIKKA LWCSEDKQIL SADDKTVRLW DHATMTEVKS LNFNMSVSSM EYIPEGEILV ITYGRSIAFH SAVSLDPIKS FEAPATINSA SLHPEKEFLV AGGEDFKLYK YDYNSGEELE SYKGHFGPIH CVRFSPDGEL YASGSEDGTL RLWQTVVGKT YGLWKCVLPE EDSGELAKPK IGFPETTEEE LEEIASENSD CIFPSAPDVK A (1-350 aa encoded by BC000162)
Target Information
STRAP is a 350 amino acid MAP activator with WD-40 repeats that is localized both in the cytoplasm and the nucleus. It is a ubiquitously expressed protein that acts as an inhibitor of TGF-beta signaling and an important regulator of cell proliferation. Stable expression of STRAP results in activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and in down-regulation of the cyclin-dependent kinase inhibitor p21 (Cip1), which results in retinoblastoma protein hyperphosphorylation. Upregulation of STRAP might play a role in tumor development as an early event for colorectal cancers. It is the first component of the U snRNP assembly machinery that associates with SMN complex in a compartment-specific way and plays a crucial role in the intracellular distribution of SMN1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: MAP activator with WD repeats; Serine-threonine kinase receptor-associated protein; UNR-interacting protein; WD-40 repeat protein PT-WD
Gene Aliases: AW557906; C78091; C79202; MAWD; PT-WD; STRAP; UNRIP
UniProt ID: (Human) Q9Y3F4, (Mouse) Q9Z1Z2, (Rat) Q5XIG8
Entrez Gene ID: (Human) 11171, (Mouse) 20901, (Rat) 297699
negative regulation of transcription from RNA polymerase II promoter
spliceosomal snRNP assembly
negative regulation of epithelial cell migration
negative regulation of epithelial to mesenchymal transition
maintenance of gastrointestinal epithelium
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of epithelial cell proliferation
negative regulation of pathway-restricted SMAD protein phosphorylation
mRNA processing
RNA splicing
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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