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Invitrogen
STS1 Polyclonal Antibody
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FIGURE: 1 / 1
STS1 Antibody (PA5-78609) in ICC/IF
Immunocytochemistry (Confocal immunofluorescence) of STS1 in paraformaldehyde-fixed A431. Samples were incubated with STS1 polyclonal antibody (Product # PA5-78609) using a dilution of 1:500 (green). Alpha-tubulin filaments were labeled with alpha Tubulin monoclonal antibody (Product # MA1-25054) (Red) at 1:2,000.
Product Details
PA5-78609
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the C-terminus region of human Sts1. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2736665
Product Specific Information
Positive Control: Target recombinant protein
Predicted Reactivity: Mouse (97%), Rat (97%), Rhesus Monkey (99%), Bovine (98%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Sts1 encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cbl-interacting protein p70; Cbl-interacting protein Sts-1; MGC15437; nm23-phosphorylated unknown substrate; SH3 domain-containing 70 kDa protein, suppressor of T-cell receptor signaling 1, nm23-phosphorylated unknown substrate; STS-1; Suppressor of T-cell receptor signaling 1; T-cell ubiquitin ligand 2; TULA-2; Tyrosine-protein phosphatase STS1/TULA2; Ubiquitin-associated and SH3 domain-containing protein B
Gene Aliases: KIAA1959; p70; STS-1; STS1; TULA-2; TULA2; UBASH3B
UniProt ID: (Human) Q8TF42
Entrez Gene ID: (Human) 84959
negative regulation of protein kinase activity
negative regulation of signal transduction
peptidyl-tyrosine dephosphorylation
negative regulation of osteoclast differentiation
negative regulation of bone resorption
regulation of release of sequestered calcium ion into cytosol
negative regulation of platelet aggregation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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