Proteintech

STXBP1 Polyclonal Antibody

STXBP1 Antibody in Immunocytochemistry (ICC/IF)

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STXBP1 Antibody (11459-1-AP) in ICC/IF

Immunofluorescent analysis of A375 cells using 11459-1-AP (STXBP1 antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

STXBP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

STXBP1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

11459-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:6,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:10-1:100

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

STXBP1 Fusion Protein Ag1978 (245-594 aa encoded by BC015749)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.46 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: HELTFQAMS YDLLPIENDV YKYETSGIGE ARVKEVLLDE DDDLWIALRH KHIAEVSQEV TRSLKDFSSS KRMNTGEKTT MRDLSQMLKK MPQYQKELSK YSTHLHLAED CMKHYQGTVD KLCRVEQDLA MGTDAEGEKI KDPMRAIVPI LLDANVSTYD KIRIILLYIF LKNGITEENL NKLIQHAQIP PEDSEIITNM AHLGVPIVTD STLRRRSKPE RKERISEQTY QLSRWTPIIK DIMEDTIEDK LDTKHYPYIS TRSSASFSTT AVSARYGHWH KNKAPGEYRS GPRLIIFILG GVSLNEMRCA YEVTQANGKW EVLIGSTHIL TPQKLLDTLK KLNKTDEEIS S (245-594 aa encoded by BC015749)

Target Information

This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

Cell reports

Murtaza N,Cheng AA,Brown CO,Meka DP,Hong S,Uy JA,El-Hajjar J,Pipko N,Unda BK,Schwanke B,Xing S,Thiruvahindrapuram B,Engchuan W,Trost B,Deneault E,Calderon de Anda F,Doble BW,Ellis J,Anagnostou E,Bader GD,Scherer SW,Lu Y,Singh KK

Tue Nov 22 00:00:00 UTC 2022

Differential requirement of NPHP1 for compartmentalized protein localization during photoreceptor outer segment development and maintenance.

PloS one

Datta P,Cribbs JT,Seo S

Wed Jul 24 00:00:00 UTC 2024

Differential requirement of NPHP1 for compartmentalized protein localization during photoreceptor outer segment development and maintenance.

PloS one

Datta P,Cribbs JT,Seo S

Wed Jul 24 00:00:00 UTC 2024

Munc13 activates the Munc18-1/syntaxin-1 complex and enables Munc18-1 to prime SNARE assembly.

The EMBO journal

Wang X,Gong J,Zhu L,Wang S,Yang X,Xu Y,Yang X,Ma C

Mon Aug 17 00:00:00 UTC 2020

Munc13 activates the Munc18-1/syntaxin-1 complex and enables Munc18-1 to prime SNARE assembly.

The EMBO journal

Wang X,Gong J,Zhu L,Wang S,Yang X,Xu Y,Yang X,Ma C

Mon Aug 17 00:00:00 UTC 2020

SNAP25/syntaxin4/VAMP2/Munc18-1 Complexes in Spinal Dorsal Horn Contributed to Inflammatory Pain.

Neuroscience

Duan XL,Guo Z,He YT,Li YX,Liu YN,Bai HH,Li HL,Hu XD,Suo ZW

Sun Mar 01 00:00:00 UTC 2020

Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly.

Nature communications

Wang S,Li Y,Gong J,Ye S,Yang X,Zhang R,Ma C

Tue Jan 08 00:00:00 UTC 2019

Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly.

Nature communications

Wang S,Li Y,Gong J,Ye S,Yang X,Zhang R,Ma C

Tue Jan 08 00:00:00 UTC 2019

Structural and Functional Analysis of the CAPS SNARE-Binding Domain Required for SNARE Complex Formation and Exocytosis.

Cell reports

Zhou H,Wei Z,Wang S,Yao D,Zhang R,Ma C

Tue Mar 19 00:00:00 UTC 2019

The myosin-tail homology domain of centrosomal protein 290 is essential for protein confinement between the inner and outer segments in photoreceptors.

The Journal of biological chemistry

Datta P,Hendrickson B,Brendalen S,Ruffcorn A,Seo S

Fri Dec 13 00:00:00 UTC 2019

Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet-Biedl syndrome.

Proceedings of the National Academy of Sciences of the United States of America

Datta P,Allamargot C,Hudson JS,Andersen EK,Bhattarai S,Drack AV,Sheffield VC,Seo S

Tue Aug 11 00:00:00 UTC 2015

Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet-Biedl syndrome.

Proceedings of the National Academy of Sciences of the United States of America

Datta P,Allamargot C,Hudson JS,Andersen EK,Bhattarai S,Drack AV,Sheffield VC,Seo S

Tue Aug 11 00:00:00 UTC 2015

Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet-Biedl syndrome.

Proceedings of the National Academy of Sciences of the United States of America

Datta P,Allamargot C,Hudson JS,Andersen EK,Bhattarai S,Drack AV,Sheffield VC,Seo S

Tue Aug 11 00:00:00 UTC 2015

Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet-Biedl syndrome.

Proceedings of the National Academy of Sciences of the United States of America

Datta P,Allamargot C,Hudson JS,Andersen EK,Bhattarai S,Drack AV,Sheffield VC,Seo S

Tue Aug 11 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: EIEE4; FLJ37475; hUNC18; MGC146482; minisatellite 10g detected by probe MMS10; munc-18c; MUNC18-1; N-Sec1; neuronal SEC1; p67; Protein unc-18 homolog 1; Protein unc-18 homolog A; rbSec1; rop; RP11-56D16.3; Syntaxin-binding protein 1; UNC-18 homolog; unc-18-1; Unc-18A; Unc18-1

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Gene Aliases: AI317162; AI326233; ANC18HA; MMS10-G; Ms10g; Munc-18a; MUNC18-1; N-sec1; NSEC1; NSEC1A; P67; Rb-sec1; RBSEC1; rbSec1A; rbSec1B; Sec1; STXBP1; Sxtbp1; UNC18; Unc18-1; UNC18A; Unc18h

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UniProt ID: (Human) P61764, (Mouse) O08599, (Rat) P61765

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Entrez Gene ID: (Human) 6812, (Mouse) 20910, (Rat) 25558

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Function(s)

SNARE binding protein binding syntaxin-1 binding protein kinase binding protein domain specific binding syntaxin binding identical protein binding poly(A) RNA binding protein N-terminus binding

Process(es)

platelet degranulation transport exocytosis vesicle docking involved in exocytosis neurotransmitter secretion neuromuscular synaptic transmission axon target recognition regulation of synaptic vesicle priming protein transport synaptic vesicle maturation vesicle-mediated transport synaptic vesicle fusion to presynaptic active zone membrane negative regulation of synaptic transmission, GABAergic negative regulation of neuron apoptotic process positive regulation of exocytosis positive regulation of calcium ion-dependent exocytosis protein stabilization long term synaptic depression platelet aggregation protein localization to plasma membrane glutamate secretion regulation of synaptic vesicle fusion to presynaptic membrane regulation of SNARE complex assembly

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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STXBP1 Polyclonal Antibody

STXBP1 Antibody (11459-1-AP) in ICC/IF

Product Details

11459-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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