Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
FIGURE: 1 / 1
STXBP1 Antibody (CL594-67137) in Flow
1X10^6 HeLa cells were intracellularly stained with 0.4 µg CoraLite®594 Anti-Human STXBP1 (CL594-67137, Clone:1B5B3) (red), or 0.4 µg Mouse IgG2a Isotype Control (CL594-66360-2, Clone: K11A1B2A2) (blue). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C).
Product Details
CL594-67137
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
1B5B3
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
593/614 nm
Form
Liquid
Purification
Protein A
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: HELTFQAMSY DLLPIENDVY KYETSGIGEA RVKEVLLDED DDLWIALRHK HIAEVSQEVT RSLKDFSSSK RMNTGEKTTM RDLSQMLKKM PQYQKELSKY STHLHLAEDC MKHYQGTVDK LCRVEQDLAM GTDAEGEKIK DPMRAIVPIL LDANVSTYDK IRIILLYIFL KNGITEENLN KLIQHAQIPP EDSEIITNMA HLGVPIVTDS TLRRRSKPER KERISEQTYQ LSRWTPIIKD IMEDTIEDKL DTKHYPYIST RSSASFSTTA VSARYGHWHK NKAPGEYRSG PRLIIFILGG VSLNEMRCAY EVTQANGKWE VLIGSTHILT PQKLLDTLKK LNKTDEEISS
Target Information
This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: EIEE4; FLJ37475; hUNC18; MGC146482; minisatellite 10g detected by probe MMS10; munc-18c; MUNC18-1; N-Sec1; neuronal SEC1; p67; Protein unc-18 homolog 1; Protein unc-18 homolog A; rbSec1; rop; RP11-56D16.3; Syntaxin-binding protein 1; UNC-18 homolog; unc-18-1; Unc-18A; Unc18-1
Gene Aliases: AI317162; AI326233; ANC18HA; MMS10-G; Ms10g; Munc-18a; MUNC18-1; N-sec1; NSEC1; NSEC1A; P67; Rb-sec1; RBSEC1; rbSec1A; rbSec1B; Sec1; STXBP1; Sxtbp1; UNC18; Unc18-1; UNC18A; Unc18h
UniProt ID: (Human) P61764, (Mouse) O08599, (Rat) P61765
Entrez Gene ID: (Human) 6812, (Mouse) 20910, (Rat) 25558
platelet degranulation
transport
exocytosis
vesicle docking involved in exocytosis
neurotransmitter secretion
neuromuscular synaptic transmission
axon target recognition
regulation of synaptic vesicle priming
protein transport
synaptic vesicle maturation
vesicle-mediated transport
synaptic vesicle fusion to presynaptic active zone membrane
negative regulation of synaptic transmission, GABAergic
negative regulation of neuron apoptotic process
positive regulation of exocytosis
positive regulation of calcium ion-dependent exocytosis
protein stabilization
long term synaptic depression
platelet aggregation
protein localization to plasma membrane
glutamate secretion
regulation of synaptic vesicle fusion to presynaptic membrane
regulation of SNARE complex assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support