Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Abnova
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Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MIGVSFEEAK SIITRAKLST RLESAWEIAF IRQKSDNIQP ENLSCTSLIE ASGEYGPQAS TLSLFSSPPE ILIPKTSSTP KTNNDILSSC EIKTGYNKTV QIPITSENST VGLSNTDVAS AWTENYGLQE KISLNPSVRF KAEKLEMALN YLGIQPTKEQ HQALRQQVQA DSKGTVSFGD FVQVARNLFC LQLDEVNVGA HEISNILDSQ LLPCDSSEAD EMERLKCERD DALKEVNTLK WPGQN
STXBP4 plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. STXBP4 inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. STXBP4 may also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FLJ16496; MGC149829; MGC50337; STX4-interacting protein; syntaxin 4 interacting protein; Syntaxin 4-interacting protein; Syntaxin-binding protein 4
Gene Aliases: STXBP4; Synip
UniProt ID: (Human) Q6ZWJ1
Entrez Gene ID: (Human) 252983
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