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Abnova
SUFU Polyclonal Antibody, MaxPab™
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Product Details
H00051684-D01P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SUFU (NP_057253.2, 1 a.a. approximately 484 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5-1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MAELRPSGAP GPTAPPAPGP TAPPAFASLF PPGLHAIYGE CRRLYPDQPN PLQVTAIVKY WLGGPDPLDY VSMYRNVGSP SANIPEHWHY ISFGLSDLYG DNRVHEFTGT DGPSGFGFEL TFRLKRETGE SAPPTWPAEL MQGLARYVFQ SENTFCSGDH VSWHSPLDNS ESRIQHMLLT EDPQMQPVQT PFGVVTFLQI VGVCTEELHS AQQWNGQGIL ELLRTVPIAG GPWLITDMRR GETIFEIDPH LQERVDKGIE TDGSNLSGVS AKCAWDDLSR PPEDDEDSRS ICIGTQPRRL SGKDTEQIRE TLRRGLEINS KPVLPPINPQ RQNGLAHDRA PSRKDSLESD SSTAIIPHEL IRTRQLESVH LKFNQESGAL IPLCLRGRLL HGRHFTYKSI TGDMAITFVS TGVEGAFATE EHPYAAHGPW LQILLTEEFV EKMLEDLEDL TSPEEFKLPK EYSWPEKKLK VSILPDVVFD SPLH
Target Information
The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: OTTHUMP00000020377; OTTHUMP00000020378; OTTHUMP00000020379; RP11-47A8.1; SUFUH; Suppressor of fused homolog
Gene Aliases: PRO1280; SUFU; SUFUH; SUFUXL; UNQ650/PRO1280
UniProt ID: (Human) Q9UMX1
Entrez Gene ID: (Human) 51684
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
neural tube closure
heart looping
ventricular septum development
regulation of transcription, DNA-templated
proteolysis
signal transduction
multicellular organism development
smoothened signaling pathway involved in ventral spinal cord interneuron specification
smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
aorta development
negative regulation of transcription factor import into nucleus
cytoplasmic sequestering of transcription factor
negative regulation of sequence-specific DNA binding transcription factor activity
skin development
negative regulation of osteoblast differentiation
negative regulation of smoothened signaling pathway
coronary vasculature development
negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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