Proteintech

SULF2 Polyclonal Antibody

View all (10) SULF2 antibodies

Questions & Answers

Questions & Answers

Antibody Testing Data (5)

SULF2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

SULF2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 5

SULF2 Antibody (12260-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human breast cancer using 12260-1-AP (SULF2 antibody) at dilution of 1:50 (under 40x lens).

SULF2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

SULF2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

SULF2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

SULF2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

SULF2 Antibody in Western Blot (WB)

Product Image Gallery

SULF2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human breast cancer using 12260-1-AP (SULF2 antibody) at dilution of 1:50 (under 40x lens).

SULF2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human breast cancer using 12260-1-AP (SULF2 antibody) at dilution of 1:50 (under 10x lens).

SULF2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human ovary using 12260-1-AP (SULF2 antibody) at dilution of 1:50 (under 40x lens).

SULF2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human ovary using 12260-1-AP (SULF2 antibody) at dilution of 1:50 (under 10x lens).

SULF2 Antibody in Western Blot (WB) — Mouse liver tissue were subjected to SDS PAGE followed by western blot with 12260-1-AP (SULF2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

Product Details

12260-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 1 publication 1 publication

Immunohistochemistry (IHC)

-

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

-

Immunocytochemistry (ICC/IF)

-

View 1 publication 1 publication

Not applicable (N/A)

-

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SULF2 Fusion Protein Ag2915 (722-870 aa encoded by BC020962)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.26 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MPGLTCFTH DNQHWQTAPF WTLGPFCACT SANNNTYWCM RTINETHNFL FCEFATGFLE YFDLNTDPYQ LMNAVNTLDR DVLNQLHVQL MELRSCKGYK QCNPRTRNMD LGLKDGGSYE QYRQFQRRKW PEMKRPSSKS LGQLWEGWEG (722-870 aa encoded by BC020962)

Target Information

Heparan sulfate 6-O-endosulfatases, such as Sulfatase 2, selectively remove 6-O-sulfate groups from heparan sulfate. Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 ).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

SULF2 enhances GDF15-SMAD axis to facilitate the initiation and progression of pancreatic cancer.

Cancer letters

He R,Shi J,Xu D,Yang J,Shen Y,Jiang YS,Tao L,Yang M,Fu X,Yang JY,Liu D,Huo Y,Shen X,Lu P,Niu N,Sun YW,Xue J,Liu W

Sun Jul 10 00:00:00 UTC 2022

SULF2 enhances GDF15-SMAD axis to facilitate the initiation and progression of pancreatic cancer.

Cancer letters

He R,Shi J,Xu D,Yang J,Shen Y,Jiang YS,Tao L,Yang M,Fu X,Yang JY,Liu D,Huo Y,Shen X,Lu P,Niu N,Sun YW,Xue J,Liu W

Sun Jul 10 00:00:00 UTC 2022

SULF2 enhances GDF15-SMAD axis to facilitate the initiation and progression of pancreatic cancer.

Cancer letters

He R,Shi J,Xu D,Yang J,Shen Y,Jiang YS,Tao L,Yang M,Fu X,Yang JY,Liu D,Huo Y,Shen X,Lu P,Niu N,Sun YW,Xue J,Liu W

Sun Jul 10 00:00:00 UTC 2022

SULF2 enhances GDF15-SMAD axis to facilitate the initiation and progression of pancreatic cancer.

Cancer letters

He R,Shi J,Xu D,Yang J,Shen Y,Jiang YS,Tao L,Yang M,Fu X,Yang JY,Liu D,Huo Y,Shen X,Lu P,Niu N,Sun YW,Xue J,Liu W

Sun Jul 10 00:00:00 UTC 2022

SULF2 enhances GDF15-SMAD axis to facilitate the initiation and progression of pancreatic cancer.

Cancer letters

He R,Shi J,Xu D,Yang J,Shen Y,Jiang YS,Tao L,Yang M,Fu X,Yang JY,Liu D,Huo Y,Shen X,Lu P,Niu N,Sun YW,Xue J,Liu W

Sun Jul 10 00:00:00 UTC 2022

SULF2 enhances GDF15-SMAD axis to facilitate the initiation and progression of pancreatic cancer.

Cancer letters

He R,Shi J,Xu D,Yang J,Shen Y,Jiang YS,Tao L,Yang M,Fu X,Yang JY,Liu D,Huo Y,Shen X,Lu P,Niu N,Sun YW,Xue J,Liu W

Sun Jul 10 00:00:00 UTC 2022

CXCR4 regulates Plasmodium development in mouse and human hepatocytes.

The Journal of experimental medicine

Bando H,Pradipta A,Iwanaga S,Okamoto T,Okuzaki D,Tanaka S,Vega-Rodríguez J,Lee Y,Ma JS,Sakaguchi N,Soga A,Fukumoto S,Sasai M,Matsuura Y,Yuda M,Jacobs-Lorena M,Yamamoto M

Mon Aug 05 00:00:00 UTC 2019

Bioinformatics

Protein Aliases: Arylsulfatase; DKFZp313E091; Extracellular sulfatase Sulf-2; FLJ44488; FLJ90554; hSulf-2; MGC126411; mSulf-2; N-acetylglucosamine-6-sulfatase; OTTHUMP00000031223; RP5-1049G16.1; sulfatase FP2

View more View less

Gene Aliases: 2010004N24Rik; AU020235; HSULF-2; KIAA1247; mKIAA1247; MSulf-2; SULF2; UNQ559/PRO1120

View more View less

UniProt ID: (Human) Q8IWU5, (Mouse) Q8CFG0

View more View less

Entrez Gene ID: (Human) 55959, (Rat) 311642, (Mouse) 72043

View more View less

arylsulfatase activity calcium ion binding N-acetylglucosamine-6-sulfatase activity catalytic activity sulfuric ester hydrolase activity hydrolase activity alkyl sulfatase activity endosulfan hemisulfate sulfatase activity endosulfan sulfate hydrolase activity metal ion binding

kidney development chondrocyte development glomerular filtration positive regulation of vascular endothelial growth factor production esophagus smooth muscle contraction positive regulation of Wnt signaling pathway heparan sulfate proteoglycan metabolic process glomerular basement membrane development glial cell-derived neurotrophic factor receptor signaling pathway negative regulation of fibroblast growth factor receptor signaling pathway embryonic skeletal system development cartilage development bone development innervation response to wounding positive regulation of catenin import into nucleus positive regulation of canonical Wnt signaling pathway liver regeneration regulation of hepatocyte proliferation sulfur compound metabolic process metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support