Product References
SUMOylation regulates Rb hyperphosphorylation and inactivation in uveal melanoma.
Cancer science
Meng F,Yuan Y,Ren H,Yue H,Xu B,Qian J
33-2400 was used in Western Blotting to provide novel insight into the mechanism underlying SUMOylation-regulated tumor growth in UM.
Tue Feb 01 00:00:00 UTC 2022
ATF3 and CH25H regulate effector trogocytosis and anti-tumor activities of endogenous and immunotherapeutic cytotoxic T lymphocytes.
Cell metabolism
Lu Z,McBrearty N,Chen J,Tomar VS,Zhang H,De Rosa G,Tan A,Weljie AM,Beiting DP,Miao Z,George SS,Berger A,Saggu G,Diehl JA,Koumenis C,Fuchs SY
33-2400 was used in Immunocytochemistry to demonstrate that tumor-derived factors (TDFs) stimulated effector trogocytosis and restricted cytotoxic T lymphocytes tumoricidal activity and viability in vitro.
Tue Sep 06 00:00:00 UTC 2022
Post-translational modification of RNA m6A demethylase ALKBH5 regulates ROS-induced DNA damage response.
Nucleic acids research
Yu F,Wei J,Cui X,Yu C,Ni W,Bungert J,Wu L,He C,Qian Z
33-2400 was used in Immunoprecipitation to uncover a molecular mechanism involving ALKBH5 PTMs and increased mRNA m6A levels that protect genomic integrity of cells in response to ROS.
Fri Jun 04 00:00:00 UTC 2021
Post-translational modification of RNA m6A demethylase ALKBH5 regulates ROS-induced DNA damage response.
Nucleic acids research
Yu F,Wei J,Cui X,Yu C,Ni W,Bungert J,Wu L,He C,Qian Z
33-2400 was used in Immunoprecipitation to uncover a molecular mechanism involving ALKBH5 PTMs and increased mRNA m6A levels that protect genomic integrity of cells in response to ROS.
Fri Jun 04 00:00:00 UTC 2021
Epigenetic Dysregulation of Mammalian Male Meiosis Caused by Interference of Recombination and Synapsis.
Cells
de la Fuente R,Pratto F,Hernández-Hernández A,Manterola M,López-Jiménez P,Gómez R,Viera A,Parra MT,Kouznetsova A,Camerini-Otero RD,Page J
33-2400 was used in Immunohistochemistry to indicate that impairment of recombination and synapsis alter the dynamics and localization pattern of epigenetic marks, as well as the transcriptional regulation of both autosomes and sex chromosomes throughout prophase-I progression.
Fri Sep 03 00:00:00 UTC 2021
CPAP enhances and maintains chronic inflammation in hepatocytes to promote hepatocarcinogenesis.
Cell death & disease
Chen RY,Yen CJ,Lin YJ,Wang JM,Tasi TF,Huang YC,Liu YW,Tsai HW,Lee MH,Hung LY
33-2400 was used in Proximity Ligation Assay (PLA) to investigate underlying mechanisms and crosstalk between centrosomal P4.1-associated protein and chronic inflammation in the liver relating to hepatocarcinogenesis.
Fri Oct 22 00:00:00 UTC 2021
Olig2 SUMOylation protects against genotoxic damage response by antagonizing p53 gene targeting.
Cell death and differentiation
Liu H,Weng W,Guo R,Zhou J,Xue J,Zhong S,Cheng J,Zhu MX,Pan SJ,Li Y
33-2400 was used in Western Blot to investigate if small ubiquitin-like modifier-1-dependent regulatory mechanism of oligodendrocyte transcription factor 2 in regulating cancer survival exists.
Sun Nov 01 00:00:00 UTC 2020
New insights into the genetic basis of premature ovarian insufficiency: Novel causative variants and candidate genes revealed by genomic sequencing.
Maturitas
Jaillard S,Bell K,Akloul L,Walton K,McElreavy K,Stocker WA,Beaumont M,Harrisson C,Jääskeläinen T,Palvimo JJ,Robevska G,Launay E,Satié AP,Listyasari N,Bendavid C,Sreenivasan R,Duros S,van den Bergen J,Henry C,Domin-Bernhard M,Cornevin L,Dejucq-Rainsford N,Belaud-Rotureau MA,Odent S,Ayers KL,Ravel C,Tucker EJ,Sinclair AH
33-2400 was used in Western Blotting to provide multiple insights into the genetic basis of POI/DOR.
Sun Nov 01 00:00:00 UTC 2020
PKCε SUMOylation Is Required for Mediating the Nociceptive Signaling of Inflammatory Pain.
Cell reports
Zhao X,Xia B,Cheng J,Zhu MX,Li Y
33-2400 was used in Western Blot to conclude that the SUMOylation of PKCε potentiates inflammatory thermal hyperalgesia through stabilizing the interaction with TRPV1 to enhance its function by phosphorylation.
Tue Oct 06 00:00:00 UTC 2020
Perturbation of maternal PIASy abundance disrupts zygotic genome activation and embryonic development via SUMOylation pathway.
Biology open
Higuchi C,Yamamoto M,Shin SW,Miyamoto K,Matsumoto K
33-2400 was used in Immunocytochemistry to conclude that PIASy is a maternal factor that is degraded after fertilization and may be important for the proper induction of zygotic genome activation and embryonic development.
Tue Oct 29 00:00:00 UTC 2019
Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies.
The Journal of biological chemistry
Sha Z,Blyszcz T,González-Prieto R,Vertegaal ACO,Goldberg AL
33-2400 was used in Western Blotting to show when ubiquitin-proteasome substrates in the nucleus are not degraded due to ubiquitin inhibition, they instead become SUMOylated and accumulate in promyelocytic leukemia protein bodies.
Fri Oct 18 00:00:00 UTC 2019
Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.
Small GTPases
Patil H,Yoon D,Bhowmick R,Cai Y,Cho KI,Ferreira PA
33-2400 was used in Western Blotting to support that Ran GTPase-dependent and independent and moonlighting roles of Ranbp2 or domains thereof and ubc9 control selectively age-dependent, neural-type and mitochondrial functions.
Fri Mar 01 00:00:00 UTC 2019
Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction.
Nature communications
Zhang FP,Malinen M,Mehmood A,Lehtiniemi T,Jääskeläinen T,Niskanen EA,Korhonen H,Laiho A,Elo LL,Ohlsson C,Kotaja N,Poutanen M,Sipilä P,Palvimo JJ
33-2400 was used in Western Blotting to study the role of androgen receptor SUMOylation in post-testicular sperm maturation and normal reproductive capability of male mice.
Fri Feb 15 00:00:00 UTC 2019
Acetylation of SUMO2 at lysine 11 favors the formation of non-canonical SUMO chains.
EMBO reports
Gärtner A,Wagner K,Hölper S,Kunz K,Rodriguez MS,Müller S
33-2400 was used in Western Blotting to report that K11 of SUMO2/3 undergoes reversible acetylation with SIRT1 being the K11 deacetylase.
Thu Nov 01 00:00:00 UTC 2018
SUMO regulates p21Cip1 intracellular distribution and with p21Cip1 facilitates multiprotein complex formation in the nucleolus upon DNA damage.
PloS one
Brun S,Abella N,Berciano MT,Tapia O,Jaumot M,Freire R,Lafarga M,Agell N
33-2400 was used in Immunohistochemistry-immunofluorescence to show that p21, SUMO, and protein SUMOylation are important for intranucleolar bodies assembly after DNA damage.
Tue Sep 19 00:00:00 UTC 2017
Myogenic differentiation triggers PML nuclear body loss and DAXX relocalization to chromocentres.
Cell death & disease
Salsman J,Rapkin LM,Margam NN,Duncan R,Bazett-Jones DP,Dellaire G
33-2400 was used in Immunocytochemistry-immunoflourescence to demonstrate that activation of skeletal muscle differentiation results in loss of PML and PML NBs prior to myotube fusion.
Thu Mar 30 00:00:00 UTC 2017
Assessing the Role of Paralog-Specific Sumoylation of HDAC1.
Methods in molecular biology (Clifton, N.J.)
Citro S,Chiocca S
332400 was used in western blot to discover SUMO-paralog-specific conjugation of HDAC1
Tue Jan 09 00:00:00 UTC 2018
Novel eosinophilic neuronal cytoplasmic inclusions in the external cuneate nucleus of humans.
Neuropathology : official journal of the Japanese Society of Neuropathology
Ito M,Nakamura K,Mori F,Miki Y,Tanji K,Wakabayashi K
33-2400 was used in immunohistochemistry - paraffin section to examine eosinophilic neuronal cytoplasmic inclusions
Sat Oct 01 00:00:00 UTC 2016
Loss of ubiquitin E2 Ube2w rescues hypersensitivity of Rnf4 mutant cells to DNA damage.
Scientific reports
Maure JF,Moser SC,Jaffray EG,F Alpi A,Hay RT
33-2400 was used in western blot to characterize the rescue of hypersensitivity of Rnf4 mutant cells to DNA damage via loss of ubiquitin E2 Ube2w
Tue May 17 00:00:00 UTC 2016
SUMO1 promotes Aβ production via the modulation of autophagy.
Autophagy
Cho SJ,Yun SM,Jo C,Lee DH,Choi KJ,Song JC,Park SI,Kim YJ,Koh YH
33-2400 was used in immunohistochemistry (frozen) to test if autophagic vacuoles formation is required for Aβ production by SUMO1.
Mon Nov 16 00:00:00 UTC 2015
Deubiquitinating activity of CYLD is impaired by SUMOylation in neuroblastoma cells.
Oncogene
Kobayashi T,Masoumi KC,Massoumi R
33-2400 was used in western blot to analyze SUMOylation in neuroblastoma cells as it impairs deubiquitinating activity of CYLD
Thu Apr 23 00:00:00 UTC 2015
Identification of SUMO E3 ligase-specific substrates using the HuProt human proteome microarray.
Methods in molecular biology (Clifton, N.J.)
Cox E,Uzoma I,Guzzo C,Jeong JS,Matunis M,Blackshaw S,Zhu H
33-2400 was used in ELISA to use the HuProt array to screen the human proteome to identify novel SUMO E3 ligase substrates.
Thu Dec 17 00:00:00 UTC 2015
The ATM signaling cascade promotes recombination-dependent pachytene arrest in mouse spermatocytes.
PLoS genetics
Pacheco S,Marcet-Ortega M,Lange J,Jasin M,Keeney S,Roig I
33-2400 was used in immunocytochemistry to study the promotion of recombination-dependent pachytene arrest in mouse spermatocytes due to the ATM signaling cascade
Sun Mar 01 00:00:00 UTC 2015
SUMOylation of AMPKα1 by PIAS4 specifically regulates mTORC1 signalling.
Nature communications
Yan Y,Ollila S,Wong IPL,Vallenius T,Palvimo JJ,Vaahtomeri K,Mäkelä TP
33-2400 was used in western blot to determine how reuglations of m TORC1 signalling occurs by SUMOylation of AMPK alpha 1 through PIAS4
Mon Nov 30 00:00:00 UTC 2015
Ubiquitin is phosphorylated by PINK1 to activate parkin.
Nature
Koyano F,Okatsu K,Kosako H,Tamura Y,Go E,Kimura M,Kimura Y,Tsuchiya H,Yoshihara H,Hirokawa T,Endo T,Fon EA,Trempe JF,Saeki Y,Tanaka K,Matsuda N
33-2400 was used in western blot to report PINK1 phosphorylates ubiquitin which results in parkin activation.
Thu Jun 05 00:00:00 UTC 2014
SUMOylation regulates the chromatin occupancy and anti-proliferative gene programs of glucocorticoid receptor.
Nucleic acids research
Paakinaho V,Kaikkonen S,Makkonen H,Benes V,Palvimo JJ
33-2400 was used in western blot to study the effect of SUMOylation on chromatin occupancy and anti-proliferative gene programs of glucocorticoid receptor
Sat Feb 01 00:00:00 UTC 2014
SUMOylation inhibits FOXM1 activity and delays mitotic transition.
Oncogene
Myatt SS,Kongsema M,Man CW,Kelly DJ,Gomes AR,Khongkow P,Karunarathna U,Zona S,Langer JK,Dunsby CW,Coombes RC,French PM,Brosens JJ,Lam EW
33-2400 was used in immunoprecipitation and western blot to investigate the role of SUMOylation on FOXM1 activity.
Thu Aug 21 00:00:00 UTC 2014
Electrophilic lipid mediator 15-deoxy-Δ12,14-prostaglandin j2 modifies glucocorticoid signaling via receptor SUMOylation.
Molecular and cellular biology
Paakinaho V,Kaikkonen S,Levonen AL,Palvimo JJ
33-2400 was used in Western Blotting to indicate that glucocorticoid receptor SUMOylation modulates the glucocorticoid signalling during acute cell stress.
Mon Sep 01 00:00:00 UTC 2014
A pathway linking oxidative stress and the Ran GTPase system in progeria.
Molecular biology of the cell
Datta S,Snow CJ,Paschal BM
33-2400 was used in Western Blotting to explore the relationship between progerin, the Ran GTPase, and oxidative stress.
Tue Apr 01 00:00:00 UTC 2014
Ubiquitin-negative, eosinophilic neuronal cytoplasmic inclusions associated with stress granules and autophagy: an immunohistochemical investigation of two cases.
Neuropathology : official journal of the Japanese Society of Neuropathology
Mori F,Watanabe Y,Miki Y,Tanji K,Odagiri S,Eto K,Wakabayashi K
33-2400 was used in immunohistochemistry to investigate the association of eosinophilic neuronal cytoplasmic inclusions with stress granules and autophagy in two clinical cases
Tue Apr 01 00:00:00 UTC 2014
Nuclear mobility and activity of FOXA1 with androgen receptor are regulated by SUMOylation.
Molecular endocrinology (Baltimore, Md.)
Sutinen P,Rahkama V,Rytinki M,Palvimo JJ
33-2400 was used in immunoprecipitation to determine if SUMOylation regulates the transcriptional activity of FOXA1
Wed Oct 01 00:00:00 UTC 2014
Identification of small ubiquitin-like modifier substrates with diverse functions using the Xenopus egg extract system.
Molecular & cellular proteomics : MCP
Ma L,Aslanian A,Sun H,Jin M,Shi Y,Yates JR,Hunter T
33-2400 was used in Western Blotting to isolate and profile new small ubiquitin-like modifier protein substrates exposed to sumoylation in the Xenopus egg extract system.
Tue Jul 01 00:00:00 UTC 2014
SUMOylation negatively modulates target gene occupancy of the KDM5B, a histone lysine demethylase.
Epigenetics
Bueno MT,Richard S
33-2400 was used in western blot to determine the post-translational modifications that regulate KDM5B.
Fri Nov 01 00:00:00 UTC 2013
AKAP9 is essential for spermatogenesis and sertoli cell maturation in mice.
Genetics
Schimenti KJ,Feuer SK,Griffin LB,Graham NR,Bovet CA,Hartford S,Pendola J,Lessard C,Schimenti JC,Ward JO
33-2400 was used in Immunohistochemistry to identify and support a novel reproductive tissue-specific role for Akap9 in the coordinated regulation of Sertoli cells in the testis.
Sat Jun 01 00:00:00 UTC 2013
Giant cell polymyositis and myocarditis associated with myasthenia gravis and thymoma.
Neuropathology : official journal of the Japanese Society of Neuropathology
Kon T,Mori F,Tanji K,Miki Y,Kimura T,Wakabayashi K
33-2400 was used in immunohistochemistry to investigate the association of giant cell polymyositis and myocarditis with myasthenia gravis and thymoma
Sat Jun 01 00:00:00 UTC 2013
Prostaglandin 15d-PGJ(2) inhibits androgen receptor signaling in prostate cancer cells.
Molecular endocrinology (Baltimore, Md.)
Kaikkonen S,Paakinaho V,Sutinen P,Levonen AL,Palvimo JJ
33-2400 was used in western blot to identify 5d-PGJ(2) as an inhibitor of androgen signaling.
Fri Feb 01 00:00:00 UTC 2013
Dynamic SUMOylation is linked to the activity cycles of androgen receptor in the cell nucleus.
Molecular and cellular biology
Rytinki M,Kaikkonen S,Sutinen P,Paakinaho V,Rahkama V,Palvimo JJ
Mon Oct 01 00:00:00 UTC 2012
Progesterone regulation of progesterone receptor membrane component 1 (PGRMC1) sumoylation and transcriptional activity in spontaneously immortalized granulosa cells.
Endocrinology
Peluso JJ,Lodde V,Liu X
33-2400 was used in immunohistochemistry to study progesterone receptor membrane component in granulosa cells.
Wed Aug 01 00:00:00 UTC 2012
Inactivation or non-reactivation: what accounts better for the silence of sex chromosomes during mammalian male meiosis?
Chromosoma
Page J,de la Fuente R,Manterola M,Parra MT,Viera A,Berríos S,Fernández-Donoso R,Rufas JS
33-2400 was used in immunocytochemistry to report the temporal and spatial appearance of transcriptional and MSCI markers, as well as transcriptional regulated chromatin modifications.
Fri Jun 01 00:00:00 UTC 2012
Ubiquitin-related proteins in neuronal and glial intranuclear inclusions in intranuclear inclusion body disease.
Pathology international
Mori F,Tanji K,Odagiri S,Hattori M,Hoshikawa Y,Kono C,Yasui K,Yokoi S,Hasegawa Y,Kamitani T,Yoshida M,Wakabayashi K
33-2400 was used in immunohistochemistry (paraffin) to measure the extent and frequency of URP-immunoreactive inclusions in intranuclear inclusion body disease.
Fri Jun 01 00:00:00 UTC 2012
Structure of Importin13-Ubc9 complex: nuclear import and release of a key regulator of sumoylation.
The EMBO journal
Grünwald M,Bono F
33-2400 was used in Western Blotting to elucidate the crystal structure of Imp13 in complex with the SUMO E2-conjugating enzyme, Ubc9.
Wed Jan 19 00:00:00 UTC 2011
Glucocorticoid-induced activation of caspase-8 protects the glucocorticoid-induced protein Gilz from proteasomal degradation and induces its binding to SUMO-1 in murine thymocytes.
Cell death and differentiation
Delfino DV,Spinicelli S,Pozzesi N,Pierangeli S,Velardi E,Bruscoli S,Martelli MP,Pettirossi V,Falchi L,Kang TB,Riccardi C
33-2400 was used in western blot to examine the cross-talk between glucocorticoid-induced leucine zipper and caspase-8 in dexamethasone-treated thymocytes
Sat Jan 01 00:00:00 UTC 2011
Overexpression of SUMO perturbs the growth and development of Caenorhabditis elegans.
Cellular and molecular life sciences : CMLS
Rytinki MM,Lakso M,Pehkonen P,Aarnio V,Reisner K,Peräkylä M,Wong G,Palvimo JJ
33-2400 was used in western blot to investigate the contribution of small ubiquitin-related modifiers to Caenorhabditis elegans development.
Sat Oct 01 00:00:00 UTC 2011
Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability.
Oncogene
Latonen L,Moore HM,Bai B,Jäämaa S,Laiho M
33-2400 was used in immunocytochemistry to identify a nucleolus-associated RNA-protein aggregate formed by proteasome activity inhibition in mammalian cells
Thu Feb 17 00:00:00 UTC 2011
The defective nuclear lamina in Hutchinson-gilford progeria syndrome disrupts the nucleocytoplasmic Ran gradient and inhibits nuclear localization of Ubc9.
Molecular and cellular biology
Kelley JB,Datta S,Snow CJ,Chatterjee M,Ni L,Spencer A,Yang CS,Cubeñas-Potts C,Matunis MJ,Paschal BM
33-2400 was used in immunocytochemistry to report that the effects of progerin are partially transduced by reduced function of Ran GTPase and SUMOylation pathways.
Mon Aug 01 00:00:00 UTC 2011
Incipient intranuclear inclusion body disease in a 78-year-old woman.
Neuropathology : official journal of the Japanese Society of Neuropathology
Mori F,Miki Y,Tanji K,Ogura E,Yagihashi N,Jensen PH,Wakabayashi K
33-2400 was used in immunohistochemistry - paraffin section to report and characterize an incipient case of intranuclear inclusion body disease
Fri Apr 01 00:00:00 UTC 2011
Sumoylation regulates nuclear localization of repressor DREAM.
Biochimica et biophysica acta
Palczewska M,Casafont I,Ghimire K,Rojas AM,Valencia A,Lafarga M,Mellström B,Naranjo JR
33-2400 was used in immunohistochemistry and western blot to report that sumoylation regulates the nuclear localization of DREAM in differentiated neurons
Sun May 01 00:00:00 UTC 2011
Sumoylation regulates nuclear localization of repressor DREAM.
Biochimica et biophysica acta
Palczewska M,Casafont I,Ghimire K,Rojas AM,Valencia A,Lafarga M,Mellström B,Naranjo JR
33-2400 was used in immunohistochemistry and western blot to report that sumoylation regulates the nuclear localization of DREAM in differentiated neurons
Sun May 01 00:00:00 UTC 2011
A small ubiquitin-related modifier-interacting motif functions as the transcriptional activation domain of Krüppel-like factor 4.
The Journal of biological chemistry
Du JX,McConnell BB,Yang VW
33-2400 was used in western blot to investigate how KLF4 and SUMO co-regulate gene expression
Fri Sep 03 00:00:00 UTC 2010
Development and validation of a method for profiling post-translational modification activities using protein microarrays.
PloS one
Del Rincón SV,Rogers J,Widschwendter M,Sun D,Sieburg HB,Spruck C
33-2400 was used in western blot to generate a protein microarray-based assay to measure post-translational modifications
Mon Jun 28 00:00:00 UTC 2010
SUMO conjugation contributes to immune deviation in nonobese diabetic mice by suppressing c-Maf transactivation of IL-4.
Journal of immunology (Baltimore, Md. : 1950)
Leavenworth JW,Ma X,Mo YY,Pauza ME
33-2400 was used in Immunoprecipitation to demonstrate that, despite normal expression, c-Maf binds poorly to the IL-4 promoter in nonobese diabetic CD4 cells.
Wed Jul 15 00:00:00 UTC 2009
Sumoylation of Prox1 controls its ability to induce VEGFR3 expression and lymphatic phenotypes in endothelial cells.
Journal of cell science
Pan MR,Chang TM,Chang HC,Su JL,Wang HW,Hung WC
33-2400 was used in Western Blotting to identify Prox1 as a novel target for small ubiquitin-like modifier 1, causing modulation of its ability to induce VEGFR3 expression and lymphatic phenotypes in endothelial cells.
Tue Sep 15 00:00:00 UTC 2009
The SUMO-E3 ligase PIAS3 targets pyruvate kinase M2.
Journal of cellular biochemistry
Spoden GA,Morandell D,Ehehalt D,Fiedler M,Jansen-Dürr P,Hermann M,Zwerschke W
33-2400 was used in western blot to identify interaction partners of M2-PK in order to discover novel links between M2-PK and cellular functions
Fri May 15 00:00:00 UTC 2009
RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation-deconjugation cycle on Borealin.
Molecular biology of the cell
Klein UR,Haindl M,Nigg EA,Muller S
33-2400 was used in Western Blotting to identify Borealin, a component of the chromosomal passenger complex, as a mitotic target of SUMO.
Thu Jan 01 00:00:00 UTC 2009
A high incidence of meiotic silencing of unsynapsed chromatin is not associated with substantial pachytene loss in heterozygous male mice carrying multiple simple robertsonian translocations.
PLoS genetics
Manterola M,Page J,Vasco C,Berríos S,Parra MT,Viera A,Rufas JS,Zuccotti M,Garagna S,Fernández-Donoso R
33-2400 was used in immunocytochemistry to identify how Robertsonian translocations occur and spread naturally
Sat Aug 01 00:00:00 UTC 2009
Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition.
Molecular & cellular proteomics : MCP
Matafora V,D'Amato A,Mori S,Blasi F,Bachi A
33-2400 was used in immunoprecipitation and western blot to investigate if the nucleolus is the key organelle in which SUMO-1 conjugates accumulate in response to proteasome inhibition
Thu Oct 01 00:00:00 UTC 2009
Small ubiquitin-like modifier 1 [corrected] mediates the resistance of prosthesis-loosening fibroblast-like synoviocytes against Fas-induced apoptosis.
Arthritis and rheumatism
Meinecke I,Pap G,Mendoza H,Drange S,Ender S,Strietholt S,Gay RE,Seyfert C,Ink B,Gay S,Pap T,Peters MA
33-2400 was used in western blot to measure small ubiquitin-like modifier 1 expression in aseptic loosening of prosthesis implants and investigate its role in prosthesis-loosening fibroblast-like synoviocytes
Wed Jul 01 00:00:00 UTC 2009
Ret Finger Protein: An E3 Ubiquitin Ligase Juxtaposed to the XY Body in Meiosis.
International journal of cell biology
Gillot I,Matthews C,Puel D,Vidal F,Lopez P
33-2400 was used in immunocytochemistry to study the localization and function of Ret Finger Protein
Thu Jul 14 00:00:00 UTC 2011
SUMO-1 transiently localizes to Cajal bodies in mammalian neurons.
Journal of structural biology
Navascues J,Bengoechea R,Tapia O,Casafont I,Berciano MT,Lafarga M
33-2400 was used in immunocytochemistry to examine SUMOYLation enzymes in Cajal bodies
Fri Aug 01 00:00:00 UTC 2008
The adenovirus E1B-55K oncoprotein induces SUMO modification of p53.
Cell cycle (Georgetown, Tex.)
Muller S,Dobner T
33-2400 was used in western blot to report that E1B-55K stimulates the post-translational modification of p53 by SUMOYlation
Sat Mar 15 00:00:00 UTC 2008
The ubiquitin-proteasome system is a key component of the SUMO-2/3 cycle.
Molecular & cellular proteomics : MCP
Schimmel J,Larsen KM,Matic I,van Hagen M,Cox J,Mann M,Andersen JS,Vertegaal AC
33-2400 was used in western blot to investigate the cross-talk between sumoylation and ubiquitination
Sat Nov 01 00:00:00 UTC 2008
E2F regulates DDB2: consequences for DNA repair in Rb-deficient cells.
Oncogene
Prost S,Lu P,Caldwell H,Harrison D
Thu May 24 00:00:00 UTC 2007
Nuclear phospholipase C gamma: punctate distribution and association with the promyelocytic leukemia protein.
Journal of proteome research
Ferguson BJ,Dovey CL,Lilley K,Wyllie AH,Rich T
33-2400 was used in western blot to show that the gamma 1 isoform of PLC associates with nuclear promyelocytic leukemia
Tue May 01 00:00:00 UTC 2007
An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity.
Molecular and cellular biology
Stankovic-Valentin N,Deltour S,Seeler J,Pinte S,Vergoten G,Guérardel C,Dejean A,Leprince D
33-2400 was used in immunocytochemistry and western blot to study posttranslational modifications that modulate the P53-HIC1-SIRT1 regulatory loop
Sun Apr 01 00:00:00 UTC 2007
Characterization of a new SUMO-1 nuclear body (SNB) enriched in pCREB, CBP, c-Jun in neuron-like UR61 cells.
Chromosoma
Navascués J,Bengoechea R,Tapia O,Vaqué JP,Lafarga M,Berciano MT
33-2400 was used in immunocytochemistry to identify the proteins concentrated in SUMO-1 nuclear bodies of UR61 cells
Mon Oct 01 00:00:00 UTC 2007
Immunocell-array for molecular dissection of multiple signaling pathways in mammalian cells.
Molecular & cellular proteomics : MCP
Zanardi A,Giorgetti L,Botrugno OA,Minucci S,Milani P,Pelicci PG,Carbone R
33-2400 was used in immunocytochemistry to develop an array-based multiplexed analysis of signaling pathways
Tue May 01 00:00:00 UTC 2007
Phosphorylation-dependent control of Pc2 SUMO E3 ligase activity by its substrate protein HIPK2.
Molecular cell
Roscic A,Möller A,Calzado MA,Renner F,Wimmer VC,Gresko E,Lüdi KS,Schmitz ML
33-2400 was used in immunocytochemistry and western blot to show that Pc2 is the SUMO E3 ligase for homeodomain interacting protein kinase 2
Fri Oct 06 00:00:00 UTC 2006
Regulation of the SUMO pathway sensitizes differentiating human endometrial stromal cells to progesterone.
Proceedings of the National Academy of Sciences of the United States of America
Jones MC,Fusi L,Higham JH,Abdel-Hafiz H,Horwitz KB,Lam EW,Brosens JJ
33-2400 was used in Western blot to demonstrate that cAMP signalling attenuates ligand-dependent sumoylation of the progesterone receptor in human endometrial stromal cells.
Tue Oct 31 00:00:00 UTC 2006
Regulation of the SUMO pathway sensitizes differentiating human endometrial stromal cells to progesterone.
Proceedings of the National Academy of Sciences of the United States of America
Jones MC,Fusi L,Higham JH,Abdel-Hafiz H,Horwitz KB,Lam EW,Brosens JJ
33-2400 was used in Western blot to demonstrate that cAMP signalling attenuates ligand-dependent sumoylation of the progesterone receptor in human endometrial stromal cells.
Tue Oct 31 00:00:00 UTC 2006
PDSM, a motif for phosphorylation-dependent SUMO modification.
Proceedings of the National Academy of Sciences of the United States of America
Hietakangas V,Anckar J,Blomster HA,Fujimoto M,Palvimo JJ,Nakai A,Sistonen L
Tue Jan 03 00:00:00 UTC 2006
The number of PML nuclear bodies increases in early S phase by a fission mechanism.
Journal of cell science
Dellaire G,Ching RW,Dehghani H,Ren Y,Bazett-Jones DP
33-2400 was used in immunocytochemistry to elucidate the role of promyelocytic leukemia nuclear bodies
Wed Mar 15 00:00:00 UTC 2006
Inhibition of DNA binding by differential sumoylation of heat shock factors.
Molecular and cellular biology
Anckar J,Hietakangas V,Denessiouk K,Thiele DJ,Johnson MS,Sistonen L
Wed Feb 01 00:00:00 UTC 2006
Inhibition of DNA binding by differential sumoylation of heat shock factors.
Molecular and cellular biology
Anckar J,Hietakangas V,Denessiouk K,Thiele DJ,Johnson MS,Sistonen L
Wed Feb 01 00:00:00 UTC 2006
p53-independent induction of rat hepatic Mdm2 following administration of phenobarbital and pregnenolone 16alpha-carbonitrile.
Toxicological sciences : an official journal of the Society of Toxicology
Nelson DM,Bhaskaran V,Foster WR,Lehman-McKeeman LD
33-2400 was used in western blot to investigate phenobarbital and pregnenolone-induced expression of murine double minute 2
Fri Dec 01 00:00:00 UTC 2006
SUMO-1 controls the protein stability and the biological function of phosducin.
The Journal of biological chemistry
Klenk C,Humrich J,Quitterer U,Lohse MJ
33-2400 was used in western blot to report that SUMOylation controls phosducin stability and function
Fri Mar 31 00:00:00 UTC 2006
Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics.
Molecular & cellular proteomics : MCP
Vertegaal AC,Andersen JS,Ogg SC,Hay RT,Mann M,Lamond AI
33-2400 was used in western blot to investigate the target protein preferences of SUMO-1 and SUMO-2
Fri Dec 01 00:00:00 UTC 2006
Sumoylation of the net inhibitory domain (NID) is stimulated by PIAS1 and has a negative effect on the transcriptional activity of Net.
Oncogene
Wasylyk C,Criqui-Filipe P,Wasylyk B
33-2400 was used in immunoprecipitation and western blot to report that repression by Net's NID involves sumoylation by Ubc9 and PIAS1
Thu Jan 27 00:00:00 UTC 2005
Transcriptional repression and cell death induced by nuclear aggregates of non-polyglutamine protein.
Neurobiology of disease
Fu L,Gao YS,Sztul E
33-2400 was used in immunocytochemistry to report that nuclear aggregation and transcriptional alterations are not unique to polyQ-containing proteins
Thu Dec 01 00:00:00 UTC 2005
Mutation of SENP1/SuPr-2 reveals an essential role for desumoylation in mouse development.
Molecular and cellular biology
Yamaguchi T,Sharma P,Athanasiou M,Kumar A,Yamada S,Kuehn MR
Wed Jun 01 00:00:00 UTC 2005
Mutation of SENP1/SuPr-2 reveals an essential role for desumoylation in mouse development.
Molecular and cellular biology
Yamaguchi T,Sharma P,Athanasiou M,Kumar A,Yamada S,Kuehn MR
Wed Jun 01 00:00:00 UTC 2005
Sumoylation of p45/NF-E2: nuclear positioning and transcriptional activation of the mammalian beta-like globin gene locus.
Molecular and cellular biology
Shyu YC,Lee TL,Ting CY,Wen SC,Hsieh LJ,Li YC,Hwang JL,Lin CC,Shen CK
33-2400 was used in Immunocytochemistry-immunoflourescence to identify a specific NF-E2 subunit sumoylation event in human erythroid cells that enhances the transactivation capability of mammalian beta-like globin.
Thu Dec 01 00:00:00 UTC 2005
Sumoylation of p45/NF-E2: nuclear positioning and transcriptional activation of the mammalian beta-like globin gene locus.
Molecular and cellular biology
Shyu YC,Lee TL,Ting CY,Wen SC,Hsieh LJ,Li YC,Hwang JL,Lin CC,Shen CK
33-2400 was used in Immunocytochemistry-immunoflourescence to identify a specific NF-E2 subunit sumoylation event in human erythroid cells that enhances the transactivation capability of mammalian beta-like globin.
Thu Dec 01 00:00:00 UTC 2005
Spatial distribution and function of sterol regulatory element-binding protein 1a and 2 homo- and heterodimers by in vivo two-photon imaging and spectroscopy fluorescence resonance energy transfer.
Molecular and cellular biology
Zoumi A,Datta S,Liaw LH,Wu CJ,Manthripragada G,Osborne TF,Lamorte VJ
Fri Apr 01 00:00:00 UTC 2005
Sumoylation of internally initiated Sp3 isoforms regulates transcriptional repression via a Trichostatin A-insensitive mechanism.
Cellular signalling
Spengler ML,Kennett SB,Moorefield KS,Simmons SO,Brattain MG,Horowitz JM
33-2400 was used in western blot to examine the functions of different Sp3 isoforms
Tue Feb 01 00:00:00 UTC 2005
SUMO-1 modification of the major immediate-early (IE) 1 and 2 proteins of human cytomegalovirus is regulated by different mechanisms and modulates the intracellular localization of the IE1, but not IE2, protein.
Archives of virology
Sadanari H,Yamada R,Ohnishi K,Matsubara K,Tanaka J
33-2400 was used in western blot to study SUMO-1-modified immediate-early 1 and 2 proteins of human cytomegalovirus
Thu Sep 01 00:00:00 UTC 2005
p14ARF interacts with the SUMO-conjugating enzyme Ubc9 and promotes the sumoylation of its binding partners.
Cell cycle (Georgetown, Tex.)
Rizos H,Woodruff S,Kefford RF
33-2400 was used in western blot to elucidate how p14ARF alterations contribute to susceptibility to cutaneous melanoma
Fri Apr 01 00:00:00 UTC 2005
Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin.
The Journal of biological chemistry
Long J,Zuo D,Park M
Fri Oct 21 00:00:00 UTC 2005
Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin.
The Journal of biological chemistry
Long J,Zuo D,Park M
Fri Oct 21 00:00:00 UTC 2005
Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin.
The Journal of biological chemistry
Long J,Zuo D,Park M
Fri Oct 21 00:00:00 UTC 2005
A mechanism for inhibiting the SUMO pathway.
Molecular cell
Boggio R,Colombo R,Hay RT,Draetta GF,Chiocca S
33-2400 was used in Western Blotting to study a mechanism for interfering with the SUMO pathway.
Fri Nov 19 00:00:00 UTC 2004
SUMO-1 modification of the Wilms' tumor suppressor WT1.
Cancer research
Smolen GA,Vassileva MT,Wells J,Matunis MJ,Haber DA
33-2400 was used in immunoprecipitation to determine if sumoylation modulates the cellular localization of WT1
Mon Nov 01 00:00:00 UTC 2004
Modification of the erythroid transcription factor GATA-1 by SUMO-1.
Proceedings of the National Academy of Sciences of the United States of America
Collavin L,Gostissa M,Avolio F,Secco P,Ronchi A,Santoro C,Del Sal G
33-2400 was used in immunoprecipitation and western blot to show that GATA-1 is sumoylated
Tue Jun 15 00:00:00 UTC 2004
SUMOylation of the human cytomegalovirus 72-kilodalton IE1 protein facilitates expression of the 86-kilodalton IE2 protein and promotes viral replication.
Journal of virology
Nevels M,Brune W,Shenk T
33-2400 was used in western blot to propose that SUMO modification of IE1-72 kDa contributes to efficient human cytomegalovirus replication by promoting the accumulation of IE2-86 kDa
Thu Jul 01 00:00:00 UTC 2004
The transactivating function of peroxisome proliferator-activated receptor gamma is negatively regulated by SUMO conjugation in the amino-terminal domain.
Genes to cells : devoted to molecular & cellular mechanisms
Yamashita D,Yamaguchi T,Shimizu M,Nakata N,Hirose F,Osumi T
33-2400 was used in western blot to investigate the role of sumoylation in the regulation of the transactivating function of PPARgamma2
Mon Nov 01 00:00:00 UTC 2004
p14 Arf promotes small ubiquitin-like modifier conjugation of Werners helicase.
The Journal of biological chemistry
Woods YL,Xirodimas DP,Prescott AR,Sparks A,Lane DP,Saville MK
33-2400 was used in western blot to study the mechanism by which p14 Arf promotes small ubiquitin-like modifier conjugation of Werners helicase
Fri Nov 26 00:00:00 UTC 2004
Small ubiquitin-like modifier 1 (SUMO-1) modification of the synergy control motif of Ad4 binding protein/steroidogenic factor 1 (Ad4BP/SF-1) regulates synergistic transcription between Ad4BP/SF-1 and Sox9.
Molecular endocrinology (Baltimore, Md.)
Komatsu T,Mizusaki H,Mukai T,Ogawa H,Baba D,Shirakawa M,Hatakeyama S,Nakayama KI,Yamamoto H,Kikuchi A,Morohashi K
33-2400 was used in EMSA to study the transcriptional regulation of Ad4 binding protein/steroidogenic factor 1
Fri Oct 01 00:00:00 UTC 2004
SUMO-1 marks the nuclear inclusions in familial neuronal intranuclear inclusion disease.
Experimental neurology
Pountney DL,Huang Y,Burns RJ,Haan E,Thompson PD,Blumbergs PC,Gai WP
33-2400 was used in immunohistochemistry and western blot to propose that recruitment of SUMO-1 modified proteins into insoluble nuclear inclusions and proteasomal dysfunction may be involved in the pathogenesis of familiar neuronal intranuclear inclusio
Sat Nov 01 00:00:00 UTC 2003
Size, position and dynamic behavior of PML nuclear bodies following cell stress as a paradigm for supramolecular trafficking and assembly.
Journal of cell science
Eskiw CH,Dellaire G,Mymryk JS,Bazett-Jones DP
33-2400 was used in Immunocytochemistry-immunoflourescence to study the principles underlying the assembly, disassembly, integrity, and dynamic behaviour of promyelocytic leukaemia bodies.
Sat Nov 01 00:00:00 UTC 2003
BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta.
Experimental cell research
Xu L,Yang L,Moitra PK,Hashimoto K,Rallabhandi P,Kaul S,Meroni G,Jensen JP,Weissman AM,D'Arpa P
33-2400 was used in immunocytochemistry to determine the subcellular localization of BTBD and BTBD2.
Fri Aug 01 00:00:00 UTC 2003
Perturbation of SUMOlation enzyme Ubc9 by distinct domain within nucleoporin RanBP2/Nup358.
The Journal of biological chemistry
Saitoh H,Pizzi MD,Wang J
Fri Feb 15 00:00:00 UTC 2002
Perturbation of SUMOlation enzyme Ubc9 by distinct domain within nucleoporin RanBP2/Nup358.
The Journal of biological chemistry
Saitoh H,Pizzi MD,Wang J
Fri Feb 15 00:00:00 UTC 2002
Pescadillo, a novel cell cycle regulatory protein abnormally expressed in malignant cells.
The Journal of biological chemistry
Kinoshita Y,Jarell AD,Flaman JM,Foltz G,Schuster J,Sopher BL,Irvin DK,Kanning K,Kornblum HI,Nelson PS,Hieter P,Morrison RS
33-2400 was used in western blot to examine the role of pescadilloin glial tumorigenesis.
Fri Mar 02 00:00:00 UTC 2001
A new spectrin, beta IV, has a major truncated isoform that associates with promyelocytic leukemia protein nuclear bodies and the nuclear matrix.
The Journal of biological chemistry
Tse WT,Tang J,Jin O,Korsgren C,John KM,Kung AL,Gwynn B,Peters LL,Lux SE
Fri Jun 29 00:00:00 UTC 2001
A new spectrin, beta IV, has a major truncated isoform that associates with promyelocytic leukemia protein nuclear bodies and the nuclear matrix.
The Journal of biological chemistry
Tse WT,Tang J,Jin O,Korsgren C,John KM,Kung AL,Gwynn B,Peters LL,Lux SE
Fri Jun 29 00:00:00 UTC 2001
Covalent modification of the transactivator protein IE2-p86 of human cytomegalovirus by conjugation to the ubiquitin-homologous proteins SUMO-1 and hSMT3b.
Journal of virology
Hofmann H,Flöss S,Stamminger T
33-2400 was used in western blot to identify binding partners of IE2 protein.
Wed Mar 01 00:00:00 UTC 2000
Bovine papillomavirus E1 protein is sumoylated by the host cell Ubc9 protein.
The Journal of biological chemistry
Rangasamy D,Wilson VG
33-2400 was used in immunoprecipitation and western blot to identify proteins that interact with bovine papillomavirus E1.
Fri Sep 29 00:00:00 UTC 2000
SUMO-1 modification of bovine papillomavirus E1 protein is required for intranuclear accumulation.
The Journal of biological chemistry
Rangasamy D,Woytek K,Khan SA,Wilson VG
33-2400 was used in western blot to study sumolyation of the E1 protein.
Fri Dec 01 00:00:00 UTC 2000
Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3.
The Journal of biological chemistry
Saitoh H,Hinchey J
33-2400 was used in immunocytochemistry and western blot to report quantitative and qualitative differences between SUMO-1 and SUMO-2/3 in vertebrate cells.
Fri Mar 03 00:00:00 UTC 2000
PIC-1/SUMO-1-modified PML-retinoic acid receptor alpha mediates arsenic trioxide-induced apoptosis in acute promyelocytic leukemia.
Molecular and cellular biology
Sternsdorf T,Puccetti E,Jensen K,Hoelzer D,Will H,Ottmann OG,Ruthardt M
33-2400 was used in western blot to study apoptosis induced by As2O3.
Thu Jul 01 00:00:00 UTC 1999
SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation.
Molecular cell
Desterro JM,Rodriguez MS,Hay RT
33-2400 was used in western blot to study SUMO-1-modified IkappaBalpha.
Sat Aug 01 00:00:00 UTC 1998
A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex.
The Journal of cell biology
Matunis MJ,Coutavas E,Blobel G
Sun Dec 01 00:00:00 UTC 1996
A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex.
The Journal of cell biology
Matunis MJ,Coutavas E,Blobel G
Sun Dec 01 00:00:00 UTC 1996
