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SUMO2 is a member of the SUMO (small ubiquitin-like modifier) protein family. This protein family functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. In vertebrates, three members of the SUMO family have been described, SUMO 1 and the functionally distinct homologues SUMO 2 and SUMO 3. SUMO modification sites present in the N terminal regions of SUMO 2 and SUMO 3 are utilized by SAE1/SAE2 (SUMO E1) and Ubc9 (SUMO E2) to form polymeric chains of SUMO 2 and SUMO 3 on protein substrates, a property not shared by SUMO 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Small ubiquitin-related modifier 2-A; SMT3 suppressor of mif two 3 homolog 2; SUMO-2-A
Gene Aliases: hsmt3; smt3b; smt3h2; sumo-2; sumo2; sumo2-a; sumo2-b; XELAEV_18044053mg
UniProt ID: (Xenopus) Q7ZTK7
Entrez Gene ID: (Xenopus) 379777
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