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Proteintech
SUPV3L1 Polyclonal Antibody
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Product Details
12826-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SUPV3L1 Fusion Protein Ag3542 (441-786 aa encoded by BC036112)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: YSLIKPSIN EKGERELEPI TTSQALQIAG RAGRFSSRFK EGEVTTMNHE DLSLLKEILK RPVDPIRAAG LHPTAEQIEM FAYHLPDATL SNLIDIFVDF SQVDGQYFVC NMDDFKFSAE LIQHIPLSLR VRYVFCTAPI NKKQPFVCSS LLQFARQYSR NEPLTFAWLR RYIKWPLLPP KNIKDLMDLE AVHDVLDLYL WLSYRFMDMF PDASLIRDLQ KELDGIIQDG VHNITKLIKM SETHKLLNLE GFPSGSQSRL SGTLKSQARR TRGTKALGSK ATEPPSPDAG ELSLASRLVQ QGLLTPDMLK QLEKEWMTQQ TEHNKEKTES GTHPKGTRRK KKEPDSD (441-786 aa encoded by BC036112 )
Target Information
Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ATP-dependent RNA helicase SUPV3L1, mitochondrial; Suppressor of var1 3-like protein 1; suppressor of var1, 3-like 1; suppressor of var1, 3-like 1(SUV3); SUV3-like helicase; SUV3-like protein 1
Gene Aliases: 6330443E10Rik; SUPV3L1; SUV3; Suv3l1
UniProt ID: (Human) Q8IYB8, (Mouse) Q80YD1, (Rat) Q5EBA1
Entrez Gene ID: (Human) 6832, (Mouse) 338359, (Rat) 294385
DNA binding
DNA helicase activity
RNA binding
double-stranded RNA binding
ATP-dependent RNA helicase activity
helicase activity
protein binding
ATP binding
3'-5' RNA helicase activity
protein homodimerization activity
poly(A) RNA binding
nucleotide binding
hydrolase activity
hydrolase activity, acting on acid anhydrides
mitochondrial mRNA catabolic process
positive regulation of mitochondrial RNA catabolic process
mitochondrial RNA 3'-end processing
DNA recombination
RNA catabolic process
positive regulation of cell growth
DNA duplex unwinding
mitochondrial ncRNA surveillance
mitochondrial mRNA surveillance
negative regulation of apoptotic process
mitochondrion morphogenesis
chromatin maintenance
mitochondrial RNA surveillance
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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