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Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Mouse, Rat, Bovine (100%) Opossum (93%) Turkey, Chicken, Xenopus (87%).
This gene is located in the surfeit gene cluster, which is comprised of very tightly linked housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein containing multiple putative transmembrane regions. In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). The specific function of this protein has not been determined but its yeast homolog is directly required for packaging glycosylated pro-alpha-factor into COPII vesicles. This gene uses multiple polyadenylation sites, resulting in transcript length variation. The existence of alternatively spliced transcript variants has been suggested, but their validity has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: surface 4 integral membrane protein; Surfeit locus protein 4
Gene Aliases: AL033340; AL033373; BOS_12104; ERV29; SURF-4; SURF4
UniProt ID: (Human) O15260, (Bovine) A7YY49, (Mouse) Q64310
Entrez Gene ID: (Human) 6836, (Bovine) 526045, (Mouse) 20932, (Rat) 619346
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