Proteintech

SURVIVIN Polyclonal Antibody

122 References
View all (86) Survivin antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

10508-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
View 102 publications 102 publications

Immunohistochemistry (IHC)

-
View 12 publications 12 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:400
-

Immunocytochemistry (ICC/IF)

1:200
View 4 publications 4 publications

Flow Cytometry (Flow)

Assay-dependent
-

Immunoprecipitation (IP)

0.5-4.0 µg
-

Miscellaneous PubMed (MISC)

-
View 2 publications 2 publications

Not applicable (N/A)

-
View 2 publications 2 publications
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Hamster, Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SURVIVIN Fusion Protein Ag0788 (1-142 aa encoded by BC008718)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.41 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MGAPTLPPA WQPFLKDHRI STFKNWPFLE GCACTPERMA EAGFIHCPTE NEPDLAQCFF CFKELEGWEP DDDPIEEHKK HSSGCAFLSV KKQFEELTLG EFLKLDRERA KNKIAKETNN KKKEFEETAK KVRRAIEQLA AMD (1-142 aa encoded by BC008718)

Target Information

Survivin (IAP4) is the smallest member of the Inhibitors of Apoptosis Protein (IAP) gene family. The IAPs are involved in multiple cell functions such as cell signaling, cell division, metabolism, and exhibits differential expression in nearly all human cancers, but not in most normal tissues. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but the Survivin gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts are involved in the regulation of survivin’s gene expression. Survivin is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics. Disruption of survivin-microtubule interactions results in loss of survivin's anti-apoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis. Survivin may counteract a default induction of apoptosis in G2/M phase. Survivin is also abundantly expressed in brain tissues (astrocytes and some neurons) of adult rats following traumatic brain injury. Survivin has been found co-expressed with NeuN (mature neuronal marker) and PCNA (a cell cycle protein). Survivin might affect regulation of neural cell proliferative responses after brain injury. At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined. The overexpression of survivin in cancer may overcome this apoptotic checkpoint and favor aberrant progression of transformed cells through mitosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Apoptosis inhibitor 4; Apoptosis inhibitor survivin; Baculoviral IAP repeat-containing protein 5; BIRC 5; EPR 1; survivin; survivin variant 3 alpha; SVV; TIAP

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Gene Aliases: AAC-11; AP14; API4; BIRC5; EPR-1; IAP4; survivin40; TIAP

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UniProt ID: (Human) O15392, (Rat) Q9JHY7, (Mouse) O70201

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Entrez Gene ID: (Human) 332, (Rat) 64041, (Mouse) 11799

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Function(s)
ubiquitin-protein transferase activity cysteine-type endopeptidase inhibitor activity protein binding microtubule binding Ran GTPase binding enzyme binding identical protein binding metal ion binding chaperone binding molecular_function zinc ion binding tubulin binding protein homodimerization activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process protein heterodimerization activity cofactor binding peptidase inhibitor activity
Process(es)
G2/M transition of mitotic cell cycle microtubule cytoskeleton organization transcription, DNA-templated protein phosphorylation chromosome segregation regulation of mitotic cell cycle regulation of signal transduction protein ubiquitination protein complex localization positive regulation of exit from mitosis cellular response to stem cell factor stimulus response to drug negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process response to peptide hormone negative regulation of neuron apoptotic process positive regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of mitotic cell cycle cell division establishment of chromosome localization response to glucocorticoid regulation of insulin secretion involved in cellular response to glucose stimulus regulation of type B pancreatic cell proliferation cellular response to ethanol mitotic spindle assembly inhibition of cysteine-type endopeptidase activity involved in apoptotic process apoptotic process sister chromatid cohesion positive regulation of cell proliferation protein sumoylation regulation of apoptotic process cytokinesis regulation of transcription, DNA-templated cell cycle mitotic nuclear division embryo development negative regulation of peptidase activity spindle checkpoint
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